The 33rd edition of the ECMS conference, a widely consolidated interdisciplinary forum for simulation and modeling researchers and practitioners that keeps its reference position year after year, brings with it two novelties: a new name and a new form of publication. In fact, to better catch in the name the actual situation of participants, the European Council for Modelling and Simulation decided to rename the event as "ECMS International Conference on Modelling and Simulation". This year, we also start a new book series of annual volumes, namely "Communications of the ECMS", which replaces the name "Proceedings" in order to acknowledge the recognition and reputation of the scientific community of simulation. This year the chosen conference venue is in Caserta, Italy. The Università degli Studi della Campania "Luigi Vanvitelli", previously known as Seconda Università degli Studi di Napoli, a state-owned university founded in 1990 with the explicit mission of meeting the cultural demand of the population living in the northern part of Campania. Caserta, famous for its wonderful royal palace, whose facilities will host the conference, is a city with a long history, already inhabited in the 5th century BC. It flourished in the middle age and then in the XVI-XVII century AD, surrounded by a geographical area rich of historical relevance that was under Roman influence.The university is characterized by its diffusion over the territory of the province of Caserta, having its 16 departments located in Caserta, Aversa and Santa Maria Capua Vetere, and Napoli, in which its roots can be found: the most of the departments are located in historical landmarks, that have been saved and recovered by specific agreements and funding. More than 25000 students from Italy and abroad study at Vanvitelli University enrolled in bachelor, master and PhD. curricula, taught as well in Italian as in English, and covering different aspects of mathematics, physics, data analytics, engineering, law, economics, political sciences, medicine, nursery, biotechnology, pharmacy, environmental sciences, cultural heritage, literature, psychology, tourism, design and architecture.We are honored to offer, besides the scientific program of the conference, consisting in more than 65 high quality accepted papers, a rich and various series of social events, as usual for the spirit of this conference.