The internationalisation of the manufacturing operations process includes decision-making about new facility implementation (NFI) and global supplier network development (GSND), whose first step is to analyse the situation of a company and its environment. The purpose of this paper is to investigate the optimal design of a manufacturing production and distribution network for global small- and medium-sized enterprises (SMEs). This research uses a mixed-integer linear programming (MILP) model to support decision-making in the analysis stage of the internationalisation of manufacturing operations for global SMEs. A real- world case study is presented to illustrate the application of the proposed model. Different scenarios were evaluated not only to identify the strengths and limitations of the mathematical programming model, but to also provide support for the next strategic decisions that the examined company has to make in the near future.