A multi-channel simultaneous emission non-invasive flow velocity measurement system is introduced and validated in this paper, which adapts to industrial large-diameter pipelines. In particular, the ultrasonic simultaneous emission mode is applied to the whole system to achieve real-time flow measurement. This technology reduces measurement errors in ultrasonic flow measurements caused by changes in fluid state and timing variations. Sixteen non-invasive ultrasonic transducers are used in the system, together with the precision measurement circuit, efficient data acquisition system and real-time display upper computer program. The flow rate can be accurately measured and displayed without interrupting the fluid flow. Furthermore, a period-invariant dual-threshold method is applied to locate feature points in the ultrasonic signals to ensure that high accuracy and stability are maintained in the final result.