A Gastric Mucigogue Action of the Alkyl Sulfates

Shay, Harry; Komarov, S. A.; Siplet, Herman; Fels, Samuel S.

doi:10.1126/science.103.2663.50

Cited by 56 publications

(62 citation statements)

References 8 publications

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“…In cases of secondary carcinoma involving the liver there is greater uniformity of opinion and several workers have agreed that the BSP test is of value in diagnosis, e.g. Paulson and Wyler (1942), Thomas and Zimmerman (1952), Shay and Siplet (1954) and Sherlock (1958) and it has been suggested that the results are abnormal because of interference with blood supply caused by the secondary deposits.…”

Section: Discussionmentioning

confidence: 99%

Bromsulphalein Excretion in p-Dimethylaminoazobenzene-Treated Rats

Js¹

1958

Br J Cancer

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Section: Discussionmentioning

confidence: 99%

Bromsulphalein Excretion in p-Dimethylaminoazobenzene-Treated Rats

Js¹

1958

Br J Cancer

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“…The use of a preparation in which the pylorus is ligated, and the animal allowed to recover from the anaesthetic and collect juice in its stomach for a number of hours, derives from the studies of Shay, Komarov, Fels, Meranze, Gruenstein, and Siplet (1946) concerning the production of gastric ulcers in rats. Most of the literature of twenty-odd papers on the method deals with the production of ulcers or with the prevention of ulceration.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Gastric Secretion in Rats by Some Quaternary Derivatives of Atropine

Shea¹

1956

British Journal of Pharmacology and Chemotherapy

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The increasing use of quaternary amines as inhibitors of gastric secretion suggested a study of some quaternary derivatives of atropine. Visscher, Seay, Tazelaar, Veldkamp, and Vander Brook (1954) have reported that hyoscine methyl bromide is a potent inhibitor of gastric secretion in rats. The reduction of gastric secretion produced by the synthetic quaternary ammonium compounds methantheline bromide (" Banthine ") and propantheline bromide (" Probanthine ") is said to be due to an atropine-like action-at least in the doses used clinically (Johnson and Wood, 1954).During the war a study (Ing, Dawes, and Wajda, 1945;Ing, 1946) of synthetic atropine analogues was undertaken, but it did not extend to substances containing the tropine nucleus. This was because the synthesis of atropine described by Robinson (1917) was still impracticable, owing to the cost of one of the starting substances. Newer methods of obtaining one of these substances, succinaldehyde, from furan are now available.The present work compares the effects of atropine sulphate and some quaternary atropine derivatives on gastric secretion in rats with the pylorus tied. The drugs used were atropine methyl iodide, atropine ethyl bromide, atropine propyl iodide, atropine benzyl chloride, and atropinep-nitrobenzyl chloride. Atropine propyl halide and p-nitrobenzyl halide do not seem to have been described before. The drugs were kindly supplied by Drs. R. G. Johnston and C. G. Haining, of Messrs. T. & H. Smith, Ltd., Edinburgh. METHODS The method used is a modification of that of Visscher et al. (1954). Male albino rats (160 to 260g. body weight) were used. They were all taken from the same colony, as rats of some strains have a poor spontaneous secretion. The animals were housed at 70°F., and fed on a pelleted diet. They were fasted in cages containing groups of six to twelve. The cages had wide-meshed wire bases to minimize coprophagy.The pre-operative fast from solid food lasted 48 hr. During the first 24 hr. of this period the animals had a choice of two bottle-feeds, one of skimmed fresh milk to which had been added 5% glucose and 0.4% NaCl, the other of water. During the next day, the animals had a choice of 5% glucose, 0.4% NaCl, and plain water. On the night before operation the animals had a choice of three drinks-0.4% NaCl, 0.2% NaCl, and water. The rats were shaved on the day before the fast, and were weighed at the end of the fasting period.Under methyl-n-propyl ether and ethyl ether anaesthesia, a 4 cm. midline abdominal incision was made, and the wound held open with self-retaining eyelid retractors. A ligature was placed around the duodenum near the pylorus, in such a way as to avoid trauma to the vessels.Five ml. of 0.8% NaCl was placed in the peritoneal cavity after the closure of the muscle layer with three silk sutures. The skin wound was closed with Michel clips and painted with collodion. The operation usually lasted 3 min.The drug, in aqueous solution, was injected intramuscularly or intraduodenally in volumes of 0.1 or 0.2 ml./100...

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“…Pv/orus ligated rat: The inhibitory activities of PAS and APS against the ulcers in duced in rats with the pylorus ligations described by Shay et al (2) were studied. Groups of 4 or 5 male Wistar rats, weighing 250-300g, were utilized following a fast of 48 hr.…”

Section: Materials and Methods Antiulcero{'ettic Actiyitiermentioning

confidence: 99%

Antiulcerogenic Property of Sodium Polyacrylate on Experimental Ulcerations in Rats

Kokue

Hayama

Nakamura

1974

Japanese Journal of Pharmacology

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The antiulcerogenic properties of sodium polyacrylate (PAS) against ex perimental ulcerations in rats were studied and compared with amylopectin sulfate (APS). Intragastric administration of PAS or APS to the pylorus ligated rat reduced ulceration. The protective effects of both drugs were dose dependant and PAS was less effective than APS. The gastric lesion induced by reserpine was inhibited by the oral ingestion of PAS mixed with sugar, while APS had no protective effect. More ingesta were found in the stomachs of the PAS group than the APS or control groups. PAS was confirmed to be an inhibitor of pepsin in vitro, but less effective than APS. Although PAS had little effect on the secretory volume of the gastric juice of the 6 hr pylorus ligated rat, it did cause a reduction of free acid in the juice. PAS did not possess anticoagulant activity.It has been observed that sodium polyacrylate (PAS) possesses protective effects on the gastroesophageal ulcers in swine (unpublished). In this report we describe the anti ulcerogenic activity of PAS on experimental ulcers in the rat.As PAS is a high molecular and polyanionic substance, experiments were carried out to compare this drug with amylopectin sulfate (APS), a known antiulcerogenic, which also has high molecular polyanion (1). As APS has a strong anticoagulant activity, the effect of the drug on coagulation was also studied. MATERIALS AND METHODS Antiulcero,{'ettic ActiyitierPv/orus ligated rat: The inhibitory activities of PAS and APS against the ulcers in duced in rats with the pylorus ligations described by Shay et al (2) were studied. Groups of 4 or 5 male Wistar rats, weighing 250-300g, were utilized following a fast of 48 hr. The surgery was carried out under ether anesthesia. A small incision was made just be low the gastroesophageal sphincter. A capsule containing 25-100 nag of the test sub stance was inserted into the stomach through the incision . Rats in the control group were given an empty capsule. After 19 hr , the rat was sacrificed and the stomach re moved. The gastric mucosa was examined under a ten times magnification . The de gree of gastric ulceration was estimated by the method of Radwan and West (3). Ul ceration of a stomach was given a score from 0 (normal) to 4 according to its severity. When the animal died from forestomach perforation within 19 hr after the ligation , one was added to the score. The maximum score for each animal was therefore 5. The

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A Gastric Mucigogue Action of the Alkyl Sulfates

Cited by 56 publications

References 8 publications

Bromsulphalein Excretion in p-Dimethylaminoazobenzene-Treated Rats

Bromsulphalein Excretion in p-Dimethylaminoazobenzene-Treated Rats

Inhibition of Gastric Secretion in Rats by Some Quaternary Derivatives of Atropine

Antiulcerogenic Property of Sodium Polyacrylate on Experimental Ulcerations in Rats

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