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Gastric secretion in response to graded doses of histamine was obtained from the whole stomach in five trained dogs, and the animals were sacrificed to determine the total number of parietal cells in the stomach. Histamine was administered by single s.c. injection (Hsc) and continuous i.v. infusion (Hiv). Maximal histamine response (MHR) was determined, and studies permitting the construction of dose-response curves were carried out in three of the five dogs. Dose-response curves for acidity and for acid output and volume during the entire duration of secretory response to Hsc were also established. The MHR was found to be a linear function of both the total number of parietal cells ( P < .01) and the fundic mucosal volume ( P < .05). The magnitude of the MHR and the PCM in the five dogs was within the respective ranges reported in man, but the mean MHR per billion cells (9.8 ± 0.44 mEq/30 min.) and the mean MHR per 100 cc fundic mucosal volume (58.2 ± 5.12 mEq/30 min.) were both about 30% less than the respective ratios in man.

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Basal gastric secretion of rats with chronic fistulas was studied before and after adrenalectomy or sham operation. A marked exponential fall in concentration and output of free and total acid resulted in virtual anacidity within 3–7 weeks following adrenalectomy. Failure in parietal cell secretion was not accompanied by significant decrease in parietal cell mass. Pepsin concentration and output as well as volume also fell exponentially but more gradually. No significant change in total chloride concentration occurred. Relative influence of concentration in determining output was 30 times greater than volume for free acid, 3 times greater for total acid, and twice as great for pepsin. Volume was responsible for almost all variability in total chloride output. Time after adrenalectomy influenced variability of volume and acid output twice as much as concurrent decrease in body weight.