A gastrointestinal stromal tumor of the jejunum associated with intrahepatic cholangiocarcinoma and pulmonary hamartoma: A case report

Lao, Xiang-Ming; Ye, Zi Yin; Guo, Rong; Guo, Zhi; Wang, Guo Hui; Li, Jin Qing; Zhang, Ya Qi

doi:10.1080/02841860902759022

Cited by 5 publications

(5 citation statements)

References 4 publications

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“…GISTs are mainly associated with luminal gastrointestinal adenocarcinomas and genitourinary neoplasms, whereas the association with primary hepatic neoplasms is rare. An extensive review of the literature yielded only 1 case of synchronous presentation of GIST and ICCC in a non-transplant patient [13]. Incidental ICCC, confirmed in the explanted liver of our patient, highlights another interesting link in the possible association of carcinogenesis of the presented multi-neoplastic disease.…”

Section: Resultsmentioning

confidence: 57%

Metachronous Gastrointestinal Stromal Tumor and Acute Leukemia after Liver Transplantation for Cholangiocellular Carcinoma:Is There a Link

Mrzljak

Košuta²,

Škrtić³

et al. 2013

Case Rep Oncol

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The synchronous or metachronous coexistence of gastrointestinal stromal tumors (GISTs) with solid and hematologic neoplasms has been addressed in a non-transplant population. However, the association with primary hepatic neoplasms and leukemias is uncommon. Scarce data exist considering association of GISTs and other neoplasms in a transplant population where long-term immunosuppression carries the additional burden of de novo malignancy. We present a case of posttransplant metachronous GIST and acute biphenotypic leukemia in a patient transplanted for intrahepatic cholangiocellular carcinoma, emphasizing the possible link between mechanisms of carcinogenesis and influence of other factors upon their development.

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Section: Resultsmentioning

confidence: 57%

Metachronous Gastrointestinal Stromal Tumor and Acute Leukemia after Liver Transplantation for Cholangiocellular Carcinoma:Is There a Link

Mrzljak

Košuta²,

Škrtić³

et al. 2013

Case Rep Oncol

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“…Synchronous cancers are defined as those where secondary tumors occur simultaneously or within 6 months of diagnosis of the primary malignancy [4]. ICC sometimes coexists with other cancers such as HCC [5–8], GIST [9, 10], thyroid cancer [11], lymphoma [12], and renal cell carcinoma [13]. Only one case with synchronous double cancer consisting of combined HCC-ICC and metastasis of a colon adenocarcinoma, which were treated by curable resection, has been reported [1].…”

Section: Discussionmentioning

confidence: 99%

Intrahepatic cholangiocarcinoma coinciding with a liver metastasis from a rectal carcinoma: a case report

et al. 2016

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BackgroundWe experience many cases of liver metastasis from colorectal cancer, but synchronous occurrence of intrahepatic cholangiocarcinoma (ICC) and liver metastasis from a rectal cancer is extremely rare. We herein report a case of ICC coinciding with a liver metastasis from a known rectal carcinoma.Case presentationA 68-year-old man was referred to our hospital for investigation of multiple liver tumors. Total colonoscopy and computed tomography (CT) revealed a rectal carcinoma, coinciding with liver metastasis. He was planned to receive chemotherapy following rectal resection. During chemotherapy for the rectal cancer, one of the liver tumors gradually grew after first shrinking. The following hepatectomy revealed the presence of intrahepatic cholangiocarcinoma (ICC). Despite intensive chemotherapy for the ICC, he passed away 6 months after the hepatectomy.ConclusionsWe should also suspect the possibility of multiple primary cancers, even if the patient has a history of cancer that is likely to cause metastatic lesions. When simultaneous neoplasms are diagnosed, systematic treatment should be targeted to the tumor with the worst prognosis.

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“…Synchronous ICC and GIST is a particularly rare condition and, to the best of our knowledge, only one case has been reported, which was treated via curative surgical resection ( 10 ). The current study reports the first case diagnosed by an ultrasound-guided targeted biopsy of a clinically suspicious lesion.…”

Section: Discussionmentioning

confidence: 99%

“…Various cases of synchronous gastrointestinal stromal tumors (GIST) and other primary gastrointestinal cancers have previously been reported ( 1 – 10 ). The majority of the published cases reported the synchronous occurrence of GIST with gastrointestinal epithelial malignancies, such as gastric or colorectal adenocarcinoma ( 1 – 4 , 6 – 9 ).…”

Section: Introductionmentioning

confidence: 99%

“…The majority of the published cases reported the synchronous occurrence of GIST with gastrointestinal epithelial malignancies, such as gastric or colorectal adenocarcinoma ( 1 – 4 , 6 – 9 ). The occurrence of synchronous GIST and an intrahepatic malignancy is particularly rare and, to the best of our knowledge, only one case has been reported regarding the synchronous presentation of GIST and intrahepatic cholangiocarcinoma (ICC) ( 10 – 12 ). Furthermore, as the liver is the most common site for GIST metastasis, the symptoms on presentation may be misleading, rendering the early diagnosis of synchronous GISTs and other primary intrahepatic neoplasms difficult ( 13 , 14 ).…”

Section: Introductionmentioning

confidence: 99%

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Synchronous occurrence of gastrointestinal stromal tumor and intrahepatic cholangiocarcinoma: A case report

et al. 2014

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Various cases of gastrointestinal stromal tumor (GIST) coinciding with other gastrointestinal malignancies have been reported to date, however, the synchronous occurrence of GIST and intrahepatic cholangiocarcinoma (ICC) is exceptionally rare and, to the best of our knowledge, has only been reported once. The coinciding malignancy has usually been encountered incidentally during surgical exploration. Thus, this is the first report where a targeted biopsy of the clinically suspicious lesion was used to determine the diagnosis of ICC concurrent with GIST. The liver is the most frequent metastatic site of GIST, therefore, additional hepatic masses may be mistakenly diagnosed as metastatic disease, rather than the presentation of multiple primary tumors. This subsequently delays the accurate diagnosis and complicates the performance of a curable resection. The current study reports a case of advanced synchronous GIST and ICC, which was operable at initial presentation, but progressed to become surgically unresectable.

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A gastrointestinal stromal tumor of the jejunum associated with intrahepatic cholangiocarcinoma and pulmonary hamartoma: A case report

Cited by 5 publications

References 4 publications

Metachronous Gastrointestinal Stromal Tumor and Acute Leukemia after Liver Transplantation for Cholangiocellular Carcinoma:Is There a Link

Metachronous Gastrointestinal Stromal Tumor and Acute Leukemia after Liver Transplantation for Cholangiocellular Carcinoma:Is There a Link

Intrahepatic cholangiocarcinoma coinciding with a liver metastasis from a rectal carcinoma: a case report

Synchronous occurrence of gastrointestinal stromal tumor and intrahepatic cholangiocarcinoma: A case report

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