A GC/MS Method for Determining UV Stabilizers in Polyethyleneterephthalate Bottles

Monteiro, Magali; Nerı́n, Cristina; Rubio, Carlos; Reyes, Félix Guillermo Reyes

doi:10.1002/(sici)1521-4168(19980501)21:5<317::aid-jhrc317>3.0.co;2-n

Cited by 30 publications

(13 citation statements)

References 29 publications

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“…Actual human exposure to DBHCB may be very low because it was not detected in polyethylenterephthalate bottles in Brazil (Monteiro et al, 1998) or polyethylene products in Japan (Kawamura et al, 1997). Consideration of these findings and the results of the present study together suggest that the human risk of adverse effects from DBHCB exposure is very low.…”

Section: Drug and Chemical Toxicology Downloaded From Informahealthcamentioning

confidence: 44%

Repeated-Dose and Reproductive Toxicity of the Ultraviolet Absorber 2-(3′,5′-Di-tert-butyl-2′-hydroxyphenyl)-5-chlorobenzotriazole in Rats

Ema

Fukunishi

Hirose

et al. 2008

Drug and Chemical Toxicology

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2-(3′,5′-Di-tert-butyl-2′-hydroxyphenyl)-5-chlorobenzotriazole (DBHCB) is widely used as an ultraviolet (UV) absorber. In this study, the repeated dose and reproductive toxicity of DBHCB was evaluated in rats. Crj:CD(SD)IGS rats were given DBHCB by gavage at 0, 2.5, 25, or 250 mg/kg/d. Male and female rats were dosed beginning 28 d before mating, and each female rat was mated with a male rat of the same dosage group. Males were dosed for a total of 56-57 d, and females were dosed for a total of 55-69 d up to Day 3 of lactation throughout the mating and pregnancy periods. Ten males from each group were killed on the next day of the last administration, and 10 females were killed on Days 4-6 after parturition. Five rats/sex treated at 0 and 250 mg/kg/d for 56 d were then kept without treatment for 14 d (recovery period). No deaths were found in any group. No effects of DBHCB on general condition, body weight, food consumption, or reproductive/developmental parameters were observed. Significant increases in serum albumin and an albumin/globulin ratio at 25 mg/kg/d and higher and alkaline phosphatase levels at 250 mg/kg/d were noted in males. The absolute and relative weights of the liver were significantly increased in males at 25 mg/kg/d and higher. Significantly increased serum albumin and absolute and relative liver weight were also found in males at 250 mg/kg/d after the recovery period. No changes in these parameters were observed in females of any DBHCB-treated groups. No significant changes in organ histopathology were found in males or females. These findings indicated a sex difference in the toxicity of DBHCB in rats.

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Section: Drug and Chemical Toxicology Downloaded From Informahealthcamentioning

confidence: 44%

Repeated-Dose and Reproductive Toxicity of the Ultraviolet Absorber 2-(3′,5′-Di-tert-butyl-2′-hydroxyphenyl)-5-chlorobenzotriazole in Rats

Ema

Fukunishi

Hirose

et al. 2008

Drug and Chemical Toxicology

View full text Add to dashboard Cite

show abstract

“…Actual human exposure to DBHCB may be estimated to be very low, because this chemical was not detected from polyethyleneterephthalate bottles in Brazil (Monteiro et al, 1998) and from polyethylene products in Japan (Kawamura et al, 1997). Consideration of these findings and the results of the current study together suggests that the risk of adverse effects of DBHCB on prenatal development of offspring is very low.…”

Section: Discussionmentioning

confidence: 59%

Evaluation of Developmental Toxicity of Ultraviolet Absorber 2-(3′,5′-Di-tert-Butyl-2′-hydroxyphenyl)-5-Chlorobenzotriazole in Rats

Ema¹,

Fukunishi²,

Matsumoto³

et al. 2006

Drug and Chemical Toxicology

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2-(3',5'-Di-tert-butyl-2'-hydroxyphenyl)-5-chlorobenzotriazole (DBHCB) is widely used as a UV absorber. In this study, the developmental toxicity of DBHCB was evaluated in rats. Pregnant rats were given DBHCB at 0, 62.5, 250, or 1000 mg kg(-1) day(-1) by gavage on days 5-19 of pregnancy. No deaths were observed in the pregnant rats of any group. No effect of DBHCB on the general conditions, body weight gain, or feed consumption was observed in the pregnant rats. There were no changes in the ovarian weight, gravid uterine weight, or necropsy findings in the maternal rats of the DBHCB-treated groups. No significant effects of DBHCB were found in the number of corpora lutea, implantations, live fetuses, resorptions or dead fetuses, incidence of pre- or postimplantation embryonic loss, viability of fetuses, fetal weight, or sex ratio of live fetuses. No significant difference in the incidence of fetuses with malformations or variations or degree of ossification was detected between the DBHCB-treated and control groups.

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“…Usually, extraction procedures are carried out with hand shaking (Garcia and others 2006). Nevertheless, sometimes ultrasonics (Marque and others 1998) or maceration (Monteiro and others 1998) could be employed to improve the process. Gramshaw and Vandenburg (1995) used dynamic headspace to extract styrene from thermoset polyester passing through the U‐tube nitrogen at 25 mL/min and heating the oven at 200 °C.…”

Section: Analytical Techniquesmentioning

confidence: 99%

Scalping of Flavors in Packaged Foods

Sajilata

Savitha

Singhal

et al. 2006

Comp Rev Food Sci Food Safe

138

106

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Food packaging, although an integral part of the food chain, has a major drawback in that, often, the packaging material interacts with the flavor constituents of the food, causing either a selective or an extensive loss of desirable food flavors or absorption of undesirable off-flavors from the packaging material, thereby resulting in an eventual loss of quality of the packaged food item. The process is called "scalping" and is of great concern to the food industry, which is always looking out for new avenues in "packaging solutions" for its final product quality needs. The review highlights the various attributes of the scalping process, explores approaches to the reduction of the manifested undesirable effects, and covers other relevant aspects.

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A GC/MS Method for Determining UV Stabilizers in Polyethyleneterephthalate Bottles

Cited by 30 publications

References 29 publications

Repeated-Dose and Reproductive Toxicity of the Ultraviolet Absorber 2-(3′,5′-Di-tert-butyl-2′-hydroxyphenyl)-5-chlorobenzotriazole in Rats

Repeated-Dose and Reproductive Toxicity of the Ultraviolet Absorber 2-(3′,5′-Di-tert-butyl-2′-hydroxyphenyl)-5-chlorobenzotriazole in Rats

Evaluation of Developmental Toxicity of Ultraviolet Absorber 2-(3′,5′-Di-tert-Butyl-2′-hydroxyphenyl)-5-Chlorobenzotriazole in Rats

Scalping of Flavors in Packaged Foods

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