A gelatin based antioxidant enriched biomaterial by grafting and saturation: Towards sustained drug delivery from antioxidant matrix

Raja, Iruthayapandi Selestin; Fathima, Nishter Nishad

doi:10.1016/j.colsurfb.2015.03.005

Cited by 22 publications

(11 citation statements)

References 45 publications

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“…In general, proteins containing amino acids with redox-sensitive side chain groups, such as Trp, Tyr, Cys, Met, and His, tend to exhibit antioxidant activity [ 1 ]. Thiol-derived biomaterials have been proven to have excellent antioxidant activity and are used in cardiac and neuronal regeneration [ 2 , 51 ].…”

Section: Resultsmentioning

confidence: 99%

“…Antioxidant biomaterials have been used in antitumor drug delivery [ 1 ], soft tissue regeneration [ 2 ], chronic wound healing [ 3 ] and cosmeceutical applications [ 4 ]. Sustained inflammatory responses in tissues and wounds usually cause accumulation of reactive oxygen species (ROS), resulting in abnormal cell growth, a disordered immune response, and slow wound healing [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Exploration of sea anemone-inspired high-performance biomaterials with enhanced antioxidant activity

Wang

Zhang

et al. 2022

Bioactive Materials

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Antioxidant biomaterials have attracted much attention in various biomedical fields because of their effective inhibition and elimination of reactive oxygen species (ROS) in pathological tissues. However, the difficulty in ensuring biocompatibility, biodegradability and bioavailability of antioxidant materials has limited their further development. Novel bioavailable antioxidant materials that are derived from natural resources are urgently needed. Here, an integrated multi-omics method was applied to fabricate antioxidant biomaterials. A key cysteine-rich thrombospondin-1 type I repeat-like (TSRL) protein was efficiently discovered from among 1262 adhesive components and then used to create a recombinant protein with a yield of 500 mg L −1 . The biocompatible TSRL protein was able to self-assemble into either a water-resistant coating through Ca 2+ -mediated coordination or redox-responsive hydrogels with tunable physical properties. The TSRL-based hydrogels showed stronger 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging rates than glutathione (GSH) and ascorbic acid (Aa) and protected cells against external oxidative stress significantly more effectively. When topically applied to mice skin, TSRL alleviated epidermal hyperplasia and suppressed the degradation of collagen and elastic fibers caused by ultraviolet radiation B (UVB) irradiation, confirming that it enhanced antioxidant activity in vivo . This is the first study to successfully characterize natural antioxidant biomaterials created from marine invertebrate adhesives, and the findings indicate the excellent prospects of these biomaterials for great applications in tissue regeneration and cosmeceuticals.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploration of sea anemone-inspired high-performance biomaterials with enhanced antioxidant activity

Wang

Zhang

et al. 2022

Bioactive Materials

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“…Moreover, phenolic-protein conjugates can act as drug delivery vehicle to ght against oxidative stress. 91 Phenolic-chitosan/gelatin conjugates based hydrogels are synthesized by laccase catalysis. Phenolic compounds can not only stabilize the structure of hydrogels but also stimulate wound healing process by inhibiting deleterious wound enzymes and bacterial growth.…”

Section: Hydrogels and Nanoparticles For Controlled Drug Releasementioning

confidence: 99%

Recent advances in phenolic–protein conjugates: synthesis, characterization, biological activities and potential applications

et al. 2019

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“…Circular dichroism (CD) analysis in Figure B complements the rheology data and illustrates the significant structural transformation induced by addition of the ROS to the C-dot–hydrogel. The CD spectrum of the C-dot–hydrogel in Figure B (solid spectrum) exhibits a negative Cotton effect, thus implying that the dipole moments orient in an anticlockwise direction in the aggregate of the gel in water. , However, addition of the Fenton reagent eliminates the CD signature (Figure B, broken spectrum), reflecting fluidization of the hydrogel. ,, …”

Section: Resultsmentioning

confidence: 99%

Detection of Reactive Oxygen Species by a Carbon-Dot–Ascorbic Acid Hydrogel

et al. 2016

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Detection of reactive oxygen species (ROS) is important in varied biological processes, disease diagnostics, and chemotherapeutic drug screening. We constructed a ROS sensor comprising an ascorbic-acid-based hydrogel encapsulating luminescent amphiphilic carbon-dots (C-dots). The sensing mechanism is based upon ROS-induced oxidation of the ascorbic acid units within the hydrogel scaffold; as a consequence, the hydrogel framework collapses resulting in aggregation of the C-dots and quenching of their luminescence. The C-dot-hydrogel platform exhibits high sensitivity and detected ROS generated chemically in solution and in actual cell environments. We demonstrate application of the C-dot-hydrogel for evaluating the efficacy of a chemotherapeutic substance, underscoring the potential of the system for drug screening applications.

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A gelatin based antioxidant enriched biomaterial by grafting and saturation: Towards sustained drug delivery from antioxidant matrix

Cited by 22 publications

References 45 publications

Exploration of sea anemone-inspired high-performance biomaterials with enhanced antioxidant activity

Exploration of sea anemone-inspired high-performance biomaterials with enhanced antioxidant activity

Recent advances in phenolic–protein conjugates: synthesis, characterization, biological activities and potential applications

Detection of Reactive Oxygen Species by a Carbon-Dot–Ascorbic Acid Hydrogel

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