1996
DOI: 10.1053/gast.1996.v110.pm8964426
|View full text |Cite
|
Sign up to set email alerts
|

A gene for hereditary pancreatitis maps to chromosome 7q35

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
118
0
15

Year Published

1998
1998
2012
2012

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 292 publications
(137 citation statements)
references
References 1 publication
2
118
0
15
Order By: Relevance
“…Using a genome-wide genetic linkage analysis, we mapped one HP gene to chromosome 7q35 in a large French HP family in 1996. 11 This linkage was concurrently identified by Whitcomb et al 10 and confirmed by Pandya et al…”
Section: Mapping Of One Hp Gene To Chromosome 7q35 By Genome-wide Linmentioning
confidence: 54%
See 1 more Smart Citation
“…Using a genome-wide genetic linkage analysis, we mapped one HP gene to chromosome 7q35 in a large French HP family in 1996. 11 This linkage was concurrently identified by Whitcomb et al 10 and confirmed by Pandya et al…”
Section: Mapping Of One Hp Gene To Chromosome 7q35 By Genome-wide Linmentioning
confidence: 54%
“…Historically, associations between pancreatitis and certain clinical variants have been reported but none of them substantiated (reviewed by Whitcomb et al 10 ). Thus positional cloning, in which a disease gene is identified by virtue of its location in the genome rather than by knowledge of its biochemical defects, was carried out.…”
Section: Mapping Of One Hp Gene To Chromosome 7q35 By Genome-wide Linmentioning
confidence: 99%
“…Trata-se de uma cromossomopatia do 7q35, onde reside o gene PRSS1, sítio de nove mutações atualmente conhecidas. A mutação de maior associação à PCH e amplamente conhecida é a R122H, descrita por Whitcomb 25 , seguida pela mutação N29I, também do mesmo gene. Outras como A16V, D22G e K23R parecem ter associação mais fraca com a doença, embora também sejam descritas na literatura médica.…”
Section: Pancreatite Aguda Recorrente Hereditária: Aspectos Genéticosunclassified
“…The specific mutations responsible for HP were identified in 1996 when it was confirmed that the hereditary pancreatitis gene could be mapped to chromosome 7q35 [5,6] . Whitcomb et al demonstrated that a mutation in these patients existed in the third exon of the cationic trypsinogen gene (PRSS1) [7] .…”
Section: The Genetics Of Hereditary Pancreatitismentioning
confidence: 99%