A general formula for equating protracted and acute regimes of radiation

Liversage, W. E.

doi:10.1259/0007-1285-42-498-432

Cited by 105 publications

(27 citation statements)

References 17 publications

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“…In those patients the treatment was converted into an equivalent single-dose and the IRT to a biologically equivalent fractionated treatment by the Liversage approach (6). The SCRT regimens with planned pauses introduced in 1978 were devised based on the Cohen model and were predicting an improved local tumour control and a decreased morbidity in the gut.…”

mentioning

confidence: 99%

Continuous or Split-Course Combined External and Intracavitary Radiotherapy of Locally Advanced Carcinoma of the Uterine Cervix

Pedersen

Bentzen

Overgaard³

1994

Acta Oncologica

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mentioning

confidence: 99%

Continuous or Split-Course Combined External and Intracavitary Radiotherapy of Locally Advanced Carcinoma of the Uterine Cervix

Pedersen

Bentzen

Overgaard³

1994

Acta Oncologica

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“…Systematic investigation of the concept of equivalence between fractionated high dose rate (FHDR) treatments and continuous low dose rate (CLDR) treatments was first undertaken by Liversage [2] at a time when FHDR brachytherapy treatments using high-activity cobalt-60 sources were being introduced to replace earlier CLDR treatments using low-activity radium-226 or caesium-137. As long as cellular repopulation during treatment is insignificant (as is the case with late-responding normal tissues), the number, n, of FHDR brachytherapy fractions required to replace an existing CLDR treatment, provided that the physical dose delivered in each case is identical, was found to be defined by the relationship n 5 mT…”

Section: Methodsmentioning

confidence: 99%

Theoretical implications of incorporating relative biological effectiveness into radiobiological equivalence relationships

Holloway

Dale²

2013

BJR

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Objective: Earlier radiobiological equivalence relationships as derived for low-linear energy transfer (LET) radiations are revisited in the light of newer radiobiological models that incorporate an allowance for relative biological effectiveness (RBE).Methods: Linear-quadratic (LQ) radiobiological equations for calculating biologically effective dose at both low-and high-LET radiations are used to derive new conditions of equivalence between a variety of radiation delivery techniques. The theoretical implications are discussed. Results:The original (pre-LQ) concept of equivalence between fractionated and continuous radiotherapy schedules, in which the same physical dose is delivered in each schedule, inherently assumed that low-LET radiation would be used in both schedules. LQ-based equivalence relationships that allow for RBE and are derived assuming equal total physical dose between schedules are shown to be valid only in limited circumstances. Removing the constraint of equality of total physical dose allows the identification of more general (and more practical) relationships. Conclusion:If the respective schedules under consideration for equivalence both involve radiations of identical LET, then the original equivalence relationships remain valid. However, if the compared schedules involve radiations of differing LET, then new (and more restrictive) equivalence relationships are found to apply. Advances in knowledge:Theoretically derived equivalence relationships based on the LQ model provide a framework for the design and intercomparison of a wide range of clinical techniques including those involving high-and/or low-LET radiations. They also provide a means of testing for the validity of variously assumed tissue repair kinetics.

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“…Already in 1969, Liversage [19] published theoretical considerations, meant as a basis for calculating equivalence between fractionated high dose rate and continuous low dose rate irradiations. Further mathematical approaches were developed in the following years [5,11,15,18,20].…”

Section: G Stilben Et a I / Radiotherapy And Oncology 42 (1997) 189-196mentioning

confidence: 99%

Biological equivalance of low dose rate to multifractionated high dose rate irradiations: investigations in mouse lip mucosa

Stüben

Kogel

Schueren

1997

Radiotherapy and Oncology

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A general formula for equating protracted and acute regimes of radiation

Cited by 105 publications

References 17 publications

Continuous or Split-Course Combined External and Intracavitary Radiotherapy of Locally Advanced Carcinoma of the Uterine Cervix

Continuous or Split-Course Combined External and Intracavitary Radiotherapy of Locally Advanced Carcinoma of the Uterine Cervix

Theoretical implications of incorporating relative biological effectiveness into radiobiological equivalence relationships

Biological equivalance of low dose rate to multifractionated high dose rate irradiations: investigations in mouse lip mucosa

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