A general nickel-catalyzed highly regioselective hydroarylation of unactivated alkenes enabled by the picolinamide auxiliary

Abstract

A practical method for regioselective hydroarylation of unactivated γ- or δ-vinyl alkylamines has been reported, enabling to facile preparation of highly value-added ε- or ζ-aryl alkylamines. The protocol employs nickel...

Recent Advances in Nonprecious Metal Catalysis

“…The products of the corresponding additions, Ni−alkyls, may undergo isomerizations that are typically hard to control. 102 Attempts to control the fate of such intermediates is at the heart of these most recent reports. It is typical to provide complementary stereoelectronic drivers to enforce the selectivity of the initial coupling or to push the Ni catalyst along the chain in the desired direction (Scheme 34).…”