A genetic analysis of lupus

Abstract

Systemic lupus erythematosus (SLE) is a complex multigenic inherited disease with susceptibility determined by a combination of genetic, environmental and stochastic factors. Although not yet defined, recent technical advances have provided the means to dissect the component genetic contributions of polygenic traits. We have applied such approaches to mouse models of spontaneous SLE and, in this report, summarize our genome wide mapping studies that identified loci predisposing to several major lupus-related traits. Through the generation and study of interval congenic lines, precise mapping, and screening of candidate genes, identification of the specific genes and mechanisms associated with some of the major loci is currently being pursued.

The effect of the phytoestrogen coumestrol on the NZB/W F1 murine model of systemic lupus

“…Phenotypic components of the model, such as mortality, glomerulonephritis and anti-chromatin antibody production, may be differentially influenced by a variety of genes. For example, Lbw8 has been linked to anti-chromatin antibody expression, whereas Lbw6 has been linked to mortality and glomerulonephritis [65]. We examined both autoantibody production and target organ damage, and our microarray analysis suggested that the main effect of coumestrol was on immune response rather than target organ susceptibility.…”

Genetic Segregation of Spontaneous Erosive Arthritis and Generalized Autoimmune Disease in the BXD2 Recombinant Inbred Strain of Mice

“…Several autoimmune loci (Lbw, Sle, Sle suppressor (Sles), Lmb and Asm2) associated with the development of generalized autoimmune disease in NZB/W, NZM2410 and (MRL-Fas lpr  B6-Fas lpr )F 2 (abbreviated as MBF2), or MRL-lpr mice, have been genetically mapped [30][31][32][33][34][35][36][37][38]. These models primarily exhibit a B-cell defect, with an accompanying T-cell defect, and the mice exhibit Total IgG2b…”

Insilico Designing of Potent Drug Targeted to Sjogren’s Syndrome Antigen La (Ssb) of Systematic Lupus Erythematosus

“…The point plot gives a diagrammatic explanation of the various parameters we encounter in the ADMET Analysis test. Before docking, energy of both the LIGANDS and the recept or proteins are reduced to the minimum, to make the molecules table and the docking efficient [11][12][13][14]. This is the most vital step of this research.…”