The effect of the phytoestrogen coumestrol on the NZB/W F1 murine model of systemic lupus

Schoenroth, Leeanne; Hart, David A.; Pollard, K. Michael; Fritzler, Marvin J.

doi:10.1016/j.jaut.2004.09.004

Cited by 19 publications

(13 citation statements)

References 68 publications

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“…These results are consistent with data implicating increased estrogen as a cause of pregnancy-induced thymic involution (Tibbetts et al, 1999). Likewise, estrogen reduces splenomegaly in a murine model of lupus (Schoenroth et al, 2004). Other studies indicate that removal of estrogen by ovariectomy results in enlargement of the thymus (Oner and Ozan, 2002).…”

Section: Figsupporting

confidence: 89%

Antiarthritic Effects of Relaxin, in Combination with Estrogen, in Rat Adjuvant-Induced Arthritis

Santora¹,

Rasa²,

Visco³

et al. 2007

J Pharmacol Exp Ther

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The incidence and severity of rheumatoid arthritis (RA) are reduced during pregnancy. Estradiol-17␤ and relaxin (RLX), hormones of pregnancy, are implicated in decreased immune responsiveness. The aim of this study was to determine the effects of estrogen and RLX, alone or in combination, on the development of adjuvant-induced arthritis (AIA) in ovariectomized (OVX) Lewis rats. Arthritis was induced on day 0 by adjuvant injection in the left hind paw. Rats were treated with estradiol valerate (E), porcine RLX, E ϩ RLX, or vehicle. Healthy OVX control animals were used for comparison. Treatment with RLX or E alone decreased adjuvant-induced inflammation in both the injected (primary) and noninjected (secondary) hind paws. Combined treatment with E and RLX was more effective than either hormone alone in blocking secondary paw inflammation. Furthermore, E plus RLX reduced changes to spleen and thymus weights induced by adjuvant injection. Both E and RLX alone decreased circulating tumor necrosis factor (TNF) ␣. The combination of E and RLX resulted in a greater decline in TNF␣ than treatment with either hormone alone. There was no effect of hormones on the proinflammatory cytokine, interleukin (IL)-1␤. The anti-inflammatory cytokine IL-10 increased in response to E and E plus RLX. In conclusion, combined therapy with E and RLX was more effective than either hormone alone in reducing chronic inflammation, joint changes, and high circulating TNF␣ associated with AIA in rats. Accordingly, these hormones could play a role in reducing RA-induced inflammation during pregnancy by an effect on the immune system.

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Section: Figsupporting

confidence: 89%

Antiarthritic Effects of Relaxin, in Combination with Estrogen, in Rat Adjuvant-Induced Arthritis

Santora¹,

Rasa²,

Visco³

et al. 2007

J Pharmacol Exp Ther

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“…Although, we cannot provide direct evidence for the effect of genistein and daidzein on insulitis at present time, genistein was reported to regulate the development of thymocytes and modulate immune function [33]. Schoenroth et al [34] showed that a phytoestrogen, coumestrol, may ameliorate some aspects of disease progression in this model of systemic autoimmunity. Lee [35] also recently reported that the supplementation of genistein (600 mg/kg diet) elevated the plasma insulin level by 2-fold in streptozotocin-induced diabetic rats.…”

Section: Hepatic Malic Enzyme G6pd Fatty Acid β-Oxidation and Cpt mentioning

confidence: 65%

Genistein and daidzein prevent diabetes onset by elevating insulin level and altering hepatic gluconeogenic and lipogenic enzyme activities in non‐obese diabetic (NOD) mice

Choi

Jung

Yeo

et al. 2007

Diabetes Metabolism Res

192

128

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These results suggest that genistein and daidzein play important roles in regulation of glucose homeostasis in type 1 diabetic mice by down-regulating G6Pase, PEPCK, fatty acid beta-oxidation and CPT activities, while up-regulating malic enzyme and G6PD activities in liver with preservation of pancreatic beta-cells. The supplementation of genistein and daidzein are seemingly helpful for preventing IDDM onset.

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“…Also, it has been found that the microbiota of people with a long-term diet rich in animal protein and saturated fat presents more Bacteroides [ 12 ]. Apart from this, other bioactive compounds from diet, such as polyphenols, are able to modulate the intestinal microbiome [ 13 ], and have shown promising results in models of autoimmune diseases [ 14 ]. To date, there are few studies which have focused on the interactions between polyphenol intake and microbiota: evidence from animal and human studies has shown that supplementation with polyphenol-rich food, such as red wine [ 15 ], tea [ 13 ], cocoa [ 16 ] or blueberries [ 17 , 18 ], modulates some intestinal bacterial populations, but the results were not conclusive.…”

Section: Introductionmentioning

confidence: 99%

Association of Polyphenols from Oranges and Apples with Specific Intestinal Microorganisms in Systemic Lupus Erythematosus Patients

et al. 2015

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Our group has recently shown the existence of a gut microbial dysbiosis in systemic lupus erythematosus (SLE), supporting previous evidence involving intestinal bacteria in the initiation and amplification of autoimmune diseases. While several studies have addressed the use of dietary fibres to modify intestinal microbiota, information about other correlated components, such as polyphenols, is scarce. The aim of this work was to identify dietary components able to influence this altered microbiota in 20 SLE women and 20 age-matched controls. Food intake was recorded by means of a food frequency questionnaire. The intake of fibres was calculated from Marlett tables, and Phenol-Explorer was used for polyphenol consumption. Results showed positive associations between flavone intake and Blautia, flavanones and Lactobacillus, and dihydrochalcones and Bifidobacterium in the SLE group. Regarding the controls, dihydroflavonols were directly associated with Faecalibacterium, whereas flavonol intake was inversely associated with Bifidobacterium. From the food sources of these polyphenols related to microbiota, orange intake was directly associated with Lactobacillus and apple with Bifidobacterium in SLE, whilst red wine was the best contributor to Faecalibacterium variation. The association between common foods and particular microbial genera, reported to be decreased in SLE, could be of great importance for these patients.

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The effect of the phytoestrogen coumestrol on the NZB/W F1 murine model of systemic lupus

Cited by 19 publications

References 68 publications

Antiarthritic Effects of Relaxin, in Combination with Estrogen, in Rat Adjuvant-Induced Arthritis

Antiarthritic Effects of Relaxin, in Combination with Estrogen, in Rat Adjuvant-Induced Arthritis

Genistein and daidzein prevent diabetes onset by elevating insulin level and altering hepatic gluconeogenic and lipogenic enzyme activities in non‐obese diabetic (NOD) mice

Association of Polyphenols from Oranges and Apples with Specific Intestinal Microorganisms in Systemic Lupus Erythematosus Patients

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