Genistein and daidzein prevent diabetes onset by elevating insulin level and altering hepatic gluconeogenic and lipogenic enzyme activities in non‐obese diabetic (NOD) mice

Choi, Myung‐Sook; Jung, Un Ju; Yeo, Jiyoung; Kim, M. J.; Lee, M. K.

doi:10.1002/dmrr.780

Cited by 192 publications

(147 citation statements)

References 53 publications

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“…37) Choi et al reported that genistein and daidzein prevent diabetes in non-obese diabetic mice. 38) In this study, fasting blood glucose and HbA 1c were both decreased in the administration of isoflavone on the feeding period of day 42 and day 92. A lower level in the serum insulin was also observed in HFISO group, but no difference was found in OGTT.…”

Section: Discussionmentioning

confidence: 48%

Anti-obese and anti-diabetic effects of a mixture of daidzin and glycitin on C57BL/6J mice fed with a high-fat diet

Zang

Igarashi

2015

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionmentioning

confidence: 48%

Anti-obese and anti-diabetic effects of a mixture of daidzin and glycitin on C57BL/6J mice fed with a high-fat diet

Zang

Igarashi

2015

Bioscience, Biotechnology, and Biochemistry

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“…Such an inconsistency between G6PDH activity and fat accumulation has also been observed in other studies. 35 In conclusion, supplemental daidzein reduced the backfat thickness, carcass fat content, concentrations of glucose and lipid metabolites in serum, and pH 24 , but increased the ICDH activity, color, intramuscular fat content, and marbling score of longissimus muscle in finishing beef cattle. These results indicated that supplementation with daidzein in diets can reduce the subcutaneous fat content, promote the accumulation of intramuscular fat, and improve marbling and quality of beef meat.…”

mentioning

confidence: 83%

Daidzein enhances intramuscular fat deposition and improves meat quality in finishing steers

Zhao

Zhou

Bao

et al. 2014

Exp Biol Med (Maywood)

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An experiment was conducted to determine the effects of soy isoflavone daidzein on carcass characteristics, fat deposition, meat quality, and blood metabolites in finishing steers. Fourteen crossbred steers were used in a 120-d finishing study. These steers were stratified by weight into groups and randomly allotted by group to one of two dietary treatments: (1) control and (2) daidzein (500 mg/kg concentrate). The steers were fed a 90% concentrate diet. Supplemental daidzein did not affect slaughter weight, hot carcass weight, and dressing percentage, but tended to reduce fat proportion (not including intramuscular fat) in carcass and backfat thickness of steers. The carcass bone proportion was greater in steers fed daidzein diets than those fed control diets. Daidzein supplementation reduced pH at 24 h after slaughtered and moisture content and increased isocitrate dehydrogenase activity, fat content (16.28% and 7.94%), marbling score (5.29 and 3.36), redness (a*), and chroma (C*) values in longissimus muscle relative to control treatment. The concentrations of blood metabolites including glucose, blood urea nitrogen, triglyceride, total cholesterol, non-esterified fatty acid, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were all lower in steers fed daidzein diets than those fed control diets. Current results suggest that supplemental daidzein can affect lipid metabolism, increase intramuscular fat content and marbling score, and improve meat quality in finishing steers. Daidzein should be a promising feed additive for production of high-quality beef meat.

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“…Soy isoflavones have beneficial effects in IDDM management: 5 the consumption of genistein or daidzein reduces the blood glucose level and improves insulinemia in type 1 diabetic rats. [6][7][8] To our knowledge, no study has investigated the effects of soy isoflavones on glycogen synthesis in the muscle of a type 1 diabetic animal model. A French company, Sojasun Technologies, has developed a powder extracted from the soybean called Fermented Soy Permeate (FSP).…”

mentioning

confidence: 99%

“…To our knowledge, the literature data showing positive effects of isoflavones on the blood glucose level [6][7][8] used supra-physiological doses (equivalent to 25 to 75 mg/kg body weight vs. 2 mg/kg) and treated the animals over a longer period (up to 8 weeks vs. 3 weeks). Our study aimed to determine the effects of FSP at physiological doses; thus, the administration of a lower soy isoflavones dose could explain the lack of improvement in the blood glucose level.…”

mentioning

confidence: 99%

A Fermented Soy Permeate Improves the Skeletal Muscle Glucose Level Without Restoring the Glycogen Content in Streptozotocin-Induced Diabetic Rats

Malardé

Vincent

Lefeuvre-Orfila

et al. 2013

Journal of Medicinal Food

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Exercise is essential into the therapeutic management of diabetic patients, but their level of exercise tolerance is lowered due to alterations of glucose metabolism. As soy isoflavones have been shown to improve glucose metabolism, this study aimed to assess the effects of a dietary supplement containing soy isoflavones and alpha-galactooligosaccharides on muscular glucose, glycogen synthase (GSase), and glycogen content in a type 1 diabetic animal model. The dietary supplement tested was a patented compound, Fermented Soy Permeate (FSP), developed by the French Company Sojasun Technologies. Forty male Wistar rats were randomly assigned to control or diabetic groups (streptozotocin, 45 mg/kg). Each group was then divided into placebo or FSP-supplemented groups. Both groups received by oral gavage, respectively, water or diluted FSP (0.1 g/day), daily for a period of 3 weeks. At the end of the protocol, glycemia was noticed after a 24-h fasting period. Glucose, total GSase, and the glycogen content were determined in the skeletal muscle (gastrocnemius). Diabetic animals showed a higher blood glucose concentration, but a lower glucose and glycogen muscle content than controls. Three weeks of FSP consumption allowed to restore the muscle glucose concentration, but failed to reduce glycemia and to normalize the glycogen content in diabetic rats. Furthermore, the glycogen content was increased in FSP-supplemented controls compared to placebo controls. Our results demonstrated that diabetic rats exhibited a depleted muscle glycogen content ( -25%). FSP-supplementation normalized the muscle glucose level without restoring the glycogen content in diabetic rats. However, it succeeded to increase it in the control group ( + 20%).KEY WORDS: alpha-galactooligosaccharides glucose metabolism soy isoflavones type 1 diabetes P hysical activity is now well integrated into the therapeutic management of diabetic patients to improve glycemic control and quality of life.

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Genistein and daidzein prevent diabetes onset by elevating insulin level and altering hepatic gluconeogenic and lipogenic enzyme activities in non‐obese diabetic (NOD) mice

Cited by 192 publications

References 53 publications

Anti-obese and anti-diabetic effects of a mixture of daidzin and glycitin on C57BL/6J mice fed with a high-fat diet

Anti-obese and anti-diabetic effects of a mixture of daidzin and glycitin on C57BL/6J mice fed with a high-fat diet

Daidzein enhances intramuscular fat deposition and improves meat quality in finishing steers

A Fermented Soy Permeate Improves the Skeletal Muscle Glucose Level Without Restoring the Glycogen Content in Streptozotocin-Induced Diabetic Rats

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