A Genetic Epidemiological Study of Carcinoma of the Fallopian Tube

Aziz, Samina; Kuperstein, Graciela; Rosen, Barry P.; Cole, David E. C.; Nedelcu, Raluca; McLaughlin, John; Narod, Steven A.

doi:10.1097/00006254-200107000-00016

Cited by 55 publications

(65 citation statements)

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“…PFTC has been described in high-risk breast-ovarian cancer families with germ-line BRCA-1 and BRCA-2 mutations [19][20][21][22]. Some studies suggested that the frequency and structure of the chromosomal changes (BRCA-1 or BRCA-2 mutations) observed in PFTC had similarities with those found in breast, serous ovarian, and uterine carcinomas, and consequently, a common molecular pathogenesis was claimed [22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

“…Some studies suggested that the frequency and structure of the chromosomal changes (BRCA-1 or BRCA-2 mutations) observed in PFTC had similarities with those found in breast, serous ovarian, and uterine carcinomas, and consequently, a common molecular pathogenesis was claimed [22][23][24][25][26]. Some cases of occult PFTC have been detected at prophylactic salpingo-oophorectomy in BRCA-1 mutation carriers [27].…”

Section: Introductionmentioning

confidence: 99%

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Fallopian Tube Carcinoma: A Review

2006

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Purpose. Primary fallopian tube carcinoma (PFTC) is a rare tumor that histologically and clinically resembles epithelial ovarian cancer (EOC). The purpose of this study is to review the current available literature data on PFTC.Patients and Results. Early clinical manifestation and prompt investigation often lead to diagnosis at an early stage of disease. However, the diagnosis of PFTC is rarely considered preoperatively and is usually first appreciated by the pathologist. Surgical staging/management and the use of chemotherapy follow the concepts used in epithelial ovarian cancer (EOC). In contrast to EOC is the importance of early lymphatic spread in this disease. The earlier diagnosis of PFTC leads to an apparent better survival compared with EOC. However, as with EOC, stage and residual tumor are the most important prognostic variables.Conclusion. Until more extensive clinical research has been performed, ovarian carcinoma management principles should be used in clinical practice. The Oncologist 2006;11:902-912

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fallopian Tube Carcinoma: A Review

2006

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“…Various studies have linked mutations in the BRCA1 and BRCA2 genes to PFTC [2][3][4], and alterations in p53 have been shown to be common in the disease; it has been suggested that these alterations may reduce survival [5,6]. Advanced stage [7,8], age [7], and the presence of residual tumor after initial surgery [7] have also been associated with decreased survival.…”

Section: Introductionmentioning

confidence: 99%

The incidence of primary fallopian tube cancer in the United States

Stewart

Wike²,

Foster

et al. 2007

Gynecologic Oncology

102

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Objective. The objective of this study was to report the incidence of primary fallopian tube carcinoma (PFTC) in the United States population and to describe associated demographic and clinical factors.Methods. A total of 3051 PFTC cases diagnosed from 1998 to 2003, reported from population-based cancer registries, were analyzed. Registries contributing data represent 83.1% of the U.S. population. Data are presented by age, race/ethnicity, U.S. census region, stage, histology, grade, and laterality. Trends in incidence over time from 1998 to 2003 are also presented.Results. The incidence rate was 0.41 per 100,000 women from 1998 to 2003. White, non-Hispanic women and women aged 60-79 had the highest incidence rates ( p b 0.0001). The majority (88%) of PFTCs were adenocarcinomas; serous adenocarcinomas accounted for 44% and endometrioid adenocarcinomas for 19% of adenocarcinoma diagnoses. Essentially half (49.9%) of PFTCs were poorly differentiated; 89% were unilateral at diagnosis. Stage at diagnosis was fairly evenly distributed among localized (36%), regional (30%), and distant (32%). Overall, rates of PFTC remained stable over time. Among women aged 65-69, incidence rates increased significantly by 3.8% per year from 1998 to 2003 ( p b 0.05).Conclusions. This report provides characteristics of PFTC using the largest number of cases assembled in one study to date. Although the demographic characteristics of PFTC are similar to those of ovarian cancer, stage at diagnosis and the stable trend observed in PFTC are in contrast to ovarian cancer. Future studies should focus on examining the increasing trend of PFTC among 65-to 69-year-old women. Published by Elsevier Inc.

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“…Furthermore, fallopian tube carcinoma could be a clinical component of the hereditary breast-ovarian cancer syndrome and may be associated with BRCA1 and BRCA2 mutations. 3 The management of PFTC is along the lines of ovarian carcinoma, with initial treatment by cytoreductive surgery followed by chemotherapy. 4 Some of the common symptoms that women present with are abnormal uterine/vaginal bleeding (50%), watery per vaginal discharge, abdominal or pelvic pain and abdominal distension.…”

Section: Discussionmentioning

confidence: 99%