The incidence of primary fallopian tube cancer in the United States

Abstract

Objective. The objective of this study was to report the incidence of primary fallopian tube carcinoma (PFTC) in the United States population and to describe associated demographic and clinical factors.Methods. A total of 3051 PFTC cases diagnosed from 1998 to 2003, reported from population-based cancer registries, were analyzed. Registries contributing data represent 83.1% of the U.S. population. Data are presented by age, race/ethnicity, U.S. census region, stage, histology, grade, and laterality. Trends in incidence over time from 1998 to 2003 are also presented.Results. The incidence rate was 0.41 per 100,000 women from 1998 to 2003. White, non-Hispanic women and women aged 60-79 had the highest incidence rates ( p b 0.0001). The majority (88%) of PFTCs were adenocarcinomas; serous adenocarcinomas accounted for 44% and endometrioid adenocarcinomas for 19% of adenocarcinoma diagnoses. Essentially half (49.9%) of PFTCs were poorly differentiated; 89% were unilateral at diagnosis. Stage at diagnosis was fairly evenly distributed among localized (36%), regional (30%), and distant (32%). Overall, rates of PFTC remained stable over time. Among women aged 65-69, incidence rates increased significantly by 3.8% per year from 1998 to 2003 ( p b 0.05).Conclusions. This report provides characteristics of PFTC using the largest number of cases assembled in one study to date. Although the demographic characteristics of PFTC are similar to those of ovarian cancer, stage at diagnosis and the stable trend observed in PFTC are in contrast to ovarian cancer. Future studies should focus on examining the increasing trend of PFTC among 65-to 69-year-old women. Published by Elsevier Inc.

Ovarian Cancer Incidence: Current and Comprehensive Statistics

“…The U.S. incidence rate of PFTC is 0.41 (Stewart et al, 2007). The vast majority of PFTCs (89%) are unilateral at diagnosis, and about 30% are diagnosed at each localized, regional and distant stages (Stewart et al, 2007). U.S. PFTC rates are similar to those reported from Finland (0.3) (Riska et al, 2003) and Denmark (0.5) (Pfeiffer et al, 1989).…”

“…In contrast, a study from a UK cancer center examining PPC found that age and tumor characteristics (stage and grade) were similar among ovarian and primary peritoneal tumors (Jaaback et al, 2006). The U.S. incidence rate of PFTC is 0.41 (Stewart et al, 2007). The vast majority of PFTCs (89%) are unilateral at diagnosis, and about 30% are diagnosed at each localized, regional and distant stages (Stewart et al, 2007).…”

Liquid-based cytology aids in primary fallopian tube cancer diagnosis

“…White, non-Hispanic women with age of 60~79 years had the highest incidence rate (P< 0.0001). The majority (88%) of PFTCs were adenocarcinomas, of which serous adenocarcinomas accounted for 44% and endometrioid adenocarcinomas for 19% (Stewart et al, 2007).…”

Primary Adenocarcinoma of the Fallopian Tube: Report of Two Cases

“…Then patient addressed to oncology department for adjuvant chemotherapy. published in 2007 involving 3051 cases reported from the cancer registry in the USA between 1998 and 2003, reported an incidence of 4.1 per million women per year [9]. In Finland the incidence is 5.4 per million between 1993 and 1997 [10].…”

“…The true incidence is certainly underestimated. Indeed, the diagnosis can be made wrongly as ovarian cancer, it is during the initial surgery or during the examination and pathology [9,10]. Primary fallopian tube cancer is associated with chronic tubal inflammation, infertility, tuberculous salpingitis and tubal endometriosis [5], it is particularly common in familial forms of breast/ovarian cancer, especially in women with constitutional mutation BRCA 1-2 [11].…”