A genome-wide association study for allergen component sensitizations identifies allergen component–specific and allergen protein group–specific associations

Morii, Wataru; Kasai, K.; Nakamura, Takako; Hayashi, Daisuke; Hara, Monami; Naito, Tatsuhiko; Sonehara, Kyuto; Fukuie, Tatsuki; Saito‐Abe, Mayako; Yang, Limin; Yamamoto‐Hanada, Kiwako; Narita, Masami; Maruo, Kazushi; Okada, Yukinori; Noguchi, Emiko; Ohya, Yukihiro

doi:10.1016/j.jacig.2023.100086

Cited by 2 publications

(1 citation statement)

References 53 publications

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“…Most GWASs, per the NHGRI-EBI GWAS catalogue [11], focus on asthma, with limited assessment of molecular allergenic sensitization. A Tokyo Children's Health, Illness, and Development study GWAS [12] on 564 children explored single allergen component sensitization (532 components) and allergenic protein families (516 families), revealing associations like the immunoglobulin heavy-chain variable gene on chromosome 14 linked to ragweed allergen (Amb a 1) sensitization. Alpha-gal syndrome (AGS) and blood type association provide a unique case.…”

Section: Genetics Of the Allergic Individual And Molecular Allergologymentioning

confidence: 99%

What molecular allergy teaches us about genetics and epidemiology of allergies

Biagioni,

Scala,

Cecchi

2024

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review To delineate pertinent information regarding the application of molecular allergology within the realm of both genetic and epidemiological facets of allergic diseases. Recent findings The emergence of molecular allergy has facilitated the comprehension of the biochemical characteristics of allergens originating from diverse sources. It has allowed for the exploration of sensitization trajectories and provided novel insights into the influence of genetics and environmental exposure on the initiation and development of allergic diseases. This review delves into the primary discoveries related to the genetics and epidemiology of allergies, facilitated by the application of molecular allergy. It also scrutinizes the impact of environmental exposure across varied geoclimatic, socioeconomic, and lifestyle contexts. Additionally, the review introduces specific models of molecular allergy within the realms of plants and animals. Summary The utilization of molecular allergy in clinical practice holds crucially acknowledged diagnostic and therapeutic implications. From a research standpoint, there is a growing need for the widespread adoption of molecular diagnostic tools to achieve a more profound understanding of the epidemiology and natural progression of allergic diseases.

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Section: Genetics Of the Allergic Individual And Molecular Allergologymentioning

confidence: 99%

What molecular allergy teaches us about genetics and epidemiology of allergies

Biagioni,

Scala,

Cecchi

2024

Current Opinion in Allergy &Amp; Clinical Immunology

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Advances in asthma and allergic disease genetics

Schoettler

2024

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review Asthma and allergic disease are common chronic conditions affecting individuals of all ages. The contribution of genetics to the risk of asthma and allergic diseases is well established, yet the mechanisms through which genetic variation contribute to risk continues to be investigated. This review focuses on recent advances made in genetic studies of asthma and allergic disease phenotypes. Recent findings Progress has been made at expanding genetic studies of asthma and allergic diseases in more diverse and non-European populations, and genetic associations have been made with loci and more refined phenotypes associated with these conditions. Among the 11 large genome-wide association studies or admixture mapping studies published recently, 52 novel associations were identified for asthma and allergic disease phenotypes. As in previous studies, variant- and genome-based heritability remains relatively low. The use of polygenic risk scores in asthma and allergic diseases has increased and reinforces the remarkable overlap of the genetic risk of these conditions. Whole genome and exome sequencing has led to associations of specific genes with these conditions, including rare STAT6 gain-of-function mutations that were identified in individuals with multiple, severe and early life allergic diseases and asthma. Summary Overall, we have learned that asthma and allergic diseases phenotypes are highly polygenic and have considerable overlap in their genetic landscapes.

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A genome-wide association study for allergen component sensitizations identifies allergen component–specific and allergen protein group–specific associations

Cited by 2 publications

References 53 publications

What molecular allergy teaches us about genetics and epidemiology of allergies

What molecular allergy teaches us about genetics and epidemiology of allergies

Advances in asthma and allergic disease genetics

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