A genome-wide scan and
            <i>HCRTR2</i>
            candidate gene analysis in a European cluster headache cohort

Baumber, L; Sjöstrand, Christina; Leone, Massimo; Harty, H.; Bussone, Gennaro; Hillert, Jan; Trembath, Richard C.; Russell, MB

doi:10.1212/01.wnl.0000219765.95038.d7

Cited by 82 publications

(79 citation statements)

References 46 publications

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“…This association was confirmed by a large study performed in Germany, showing that homozygous carriers of the G allele had a twofold increase in risk for the disease [15]. On the contrary, the association was not replicated in a complex dataset of CH patients of Danish, Swedish, and British origin [16].…”

Section: Introductionmentioning

confidence: 90%

“…All three of these studies met the inclusion criteria. The study of Baumber et al [16] was performed using three different populations, collected in the UK, Sweden and Denmark. So, in the metaanalysis, the three groups were considered separately ( Table 1).…”

Section: Eligible Studiesmentioning

confidence: 99%

“…The 1246 G/A polymorphism was genotyped using polymerase chain reaction (PCR) followed by enzymatic digestion with gel electrophoresis as previously described. The study of Baumber et al [16] also investigated the 224.26 A>C polymorphism (rs3122169) of the HCRTR2 gene, but this polymorphism was not taken into consideration in the present analysis.…”

Section: Eligible Studiesmentioning

confidence: 99%

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Association between the G1246A polymorphism of the hypocretin receptor 2 gene and cluster headache: a meta-analysis

et al. 2007

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The objective of this study was to investigate the association between polymorphisms of the hypocretin receptor 2 gene (HCRTR2) and the risk of cluster headache (CH). The study is a meta-analysis of published case-control studies investigating the association between polymorphisms of the HCRTR2 gene and CH. Pooled odds ratios (OR) were estimated using both random (RE) and fixed effects (FE) models. Three studies, performed in five different European countries, with 593 cases and 599 controls, were included in the study. Allele G of the G1246A HCRTR2 polymorphism was significantly associated with CH (FE OR 1.58, CI 95% 1.27–1.95; RE OR 1.55 (1.14–2.12)). Carriers of the GG genotype showed a higher disease risk compared to the remaining genotypes (FE OR 1.75, CI 95% 1.37–2.25; RE OR 1.69, CI 95% 1.11–2.58). Our data confirm that the G1246A polymorphism of the HCRTR2 gene may modulate the genetic risk for CH.

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Section: Introductionmentioning

confidence: 90%

Section: Eligible Studiesmentioning

confidence: 99%

Section: Eligible Studiesmentioning

confidence: 99%

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Association between the G1246A polymorphism of the hypocretin receptor 2 gene and cluster headache: a meta-analysis

et al. 2007

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“…In a study by Schurks et al [37], it was found that having the G1246A polymorphism in this gene increases the odds ratio of having cluster headaches to 1.97, compared with controls. However, in a study by Baumber et al [38] that evaluated sporadic cluster headaches, no association was seen. These conflicting data suggest that the cluster headache may have a genetic component, whereas the sporadic component would be more difficult to identify as the genetic association.…”

Section: Hypocretin Receptor 2 (Hcrtr2)mentioning

confidence: 91%

Genetics of migraine headache in children

Hershey

2007

Current Science Inc

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A family history of migraine is very frequently noted when evaluating a child for recurrent headaches. This implies an inherited or genetic basis as a component to the underlying pathophysiology. A variety of techniques have begun to elucidate this contribution, including historical observation, population-based studies including family and twin studies, gene polymorphism association studies, and specific gene identification for isolated migraine subtypes. This line of investigation should progress in the future to a better understanding of migraine and clarification of the diagnostic subtypes for a genotype-phenotype association.

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“…These studies point to the role that the posterior hypothalamus has as physiological modulator of TNC neurons [43]. A derangement in the hypothalamic orexinergic system has been invoked in CH pathophysiology and genetic studies give support to this idea [44], even if a large multinational genetic study does not confirm this [45].…”

Section: Putative Mechanism Of Action Of Hypothalamic Stimulationmentioning

confidence: 99%

From neuroimaging to patients’ bench: what we have learnt from trigemino-autonomic pain syndromes

et al. 2012

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Trigeminal autonomic cephalalgias (TACs) are primary headaches including cluster headache, paroxysmal hemicrania, and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT). A number of neuroimaging studies have been conducted in last decade showing involvement of brain areas included in the pain matrix. Apart from pain matrix involvement, other neuroimaging findings data deserve special attention. The hypothalamic activation reported in the course of TAC attacks coupled with the efficacy of hypothalamic neurostimulation to treat drug-resistant TAC forms clearly indicate the posterior hypothalamus as a crucial area in TAC pathophysiology. In animal models this brain area has been shown to modulate craniofacial pain; moreover, hypothalamic activation occurs in other pain conditions, suggesting that posterior hypothalamus has a more complex role in TAC pathophysiology rather than simply being considered as a trigger. In contrast, hypothalamic activation may serve as a crucial area in terminating rather than triggering attacks. It also could lead to a central condition facilitating initiation of TAC attacks.

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A genome-wide scan and HCRTR2 candidate gene analysis in a European cluster headache cohort

Abstract: Cluster headache is a complex genetic disorder, with possible phenotypic and genetic heterogeneity compounding attempts at gene identification.

Cited by 82 publications

References 46 publications

Association between the G1246A polymorphism of the hypocretin receptor 2 gene and cluster headache: a meta-analysis

Association between the G1246A polymorphism of the hypocretin receptor 2 gene and cluster headache: a meta-analysis

Genetics of migraine headache in children

From neuroimaging to patients’ bench: what we have learnt from trigemino-autonomic pain syndromes

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