Genetics of migraine headache in children

Hershey, Andrew D.

doi:10.1007/s11916-007-0222-4

Cited by 7 publications

(7 citation statements)

References 41 publications

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“…If both of the parents have the trait, the offspring are more likely to have spontaneous trigeminal allodynia than if 1 parent has the trait. This has been demonstrated in families with migraine 36,37 . The third way that STA rats are similar to persons with migraine is that STA rats have increased sound sensitivity in comparison to normal control rats (+10.9 dB); this is similar to the differences in sound sensitivity between migraineurs and non‐migraineurs (+12‐14 dB) 20,21 .…”

Section: Discussionmentioning

confidence: 64%

“…This has been demonstrated in families with migraine. 36,37 The third way that STA rats are similar to persons with migraine is that STA rats have increased sound sensitivity in comparison to normal control rats (+10.9 dB); this is similar to the differences in sound sensitivity between migraineurs and non-migraineurs (+12-14 dB). 20,21 The increased sensitivity to chemical headache triggers, including GTN and CGRP, is the fourth way that STA rats are similar to migraineurs.…”

Section: Discussionmentioning

confidence: 74%

“…Inherited Allodynia Trait.-Several clinical studies suggest that genetics plays an important role in migraine. 36,37 Migraine runs in families, and there is a high rate of migraine in twins reared together or apart. Heritability estimates ranged from 30 to 65% across studies.…”

Section: Discussionmentioning

confidence: 99%

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Spontaneous Trigeminal Allodynia in Rats: A Model of Primary Headache

et al. 2012

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Animal models are essential for studying the pathophysiology of headache disorders and as a screening tool for new therapies. Most animal models modify a normal animal in an attempt to mimic migraine symptoms. They require manipulation to activate the trigeminal nerve or dural nociceptors. At best, they are models of secondary headache. No existing model can address the fundamental question: How is a primary headache spontaneously initiated? In the process of obtaining baseline periorbital von Frey thresholds in a wild-type Sprague-Dawley rat, we discovered a rat with spontaneous episodic trigeminal allodynia (manifested by episodically changing periorbital pain threshold). Subsequent mating showed that the trait is inherited. Animals with spontaneous trigeminal allodynia allow us to study the pathophysiology of primary recurrent headache disorders. To validate this as a model for migraine, we tested the effects of clinically proven acute and preventive migraine treatments on spontaneous changes in rat periorbital sensitivity. Sumatriptan, ketorolac, and dihydroergotamine temporarily reversed the low periorbital pain thresholds. Thirty days of chronic valproic acid treatment prevented spontaneous changes in trigeminal allodynia. After discontinuation, the rats returned to their baseline of spontaneous episodic threshold changes. We also tested the effects of known chemical human migraine triggers. On days when the rats did not have allodynia and showed normal periorbital von Frey thresholds, glycerol trinitrate and calcitonin gene related peptide induced significant decreases in the periorbital pain threshold. This model can be used as a predictive model for drug development and for studies of putative biomarkers for headache diagnosis and treatment.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 74%

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Spontaneous Trigeminal Allodynia in Rats: A Model of Primary Headache

et al. 2012

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“…Migraine headache is the most common primary headache disorder, affecting 15–20% of the general population with a peak incidence within the third and fourth decades of life (111). This condition has a strong hereditary basis with a positive family history frequently noted among patients (112). In the authors’ experience, the effect of SRC on pre-existing migraine headaches can be highly variable with some patients returning to their neurological baseline without exacerbation of their migraine headaches and others developing worsening migraines that require pharmacological intervention.…”

Section: Managementmentioning

confidence: 99%

Multi-Disciplinary Management of Athletes with Post-Concussion Syndrome: An Evolving Pathophysiological Approach

2016

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Historically, patients with sports-related concussion (SRC) have been managed in a uniform fashion consisting mostly of prescribed physical and cognitive rest with the expectation that all symptoms will spontaneously resolve with time. Although this approach will result in successful return to school and sports activities in the majority of athletes, an important proportion will develop persistent concussion symptoms characteristic of post-concussion syndrome (PCS). Recent advances in exercise science, neuroimaging, and clinical research suggest that the clinical manifestations of PCS are mediated by unique pathophysiological processes that can be identified by features of the clinical history and physical examination as well as the use of graded aerobic treadmill testing. Athletes who develop PCS represent a unique population whose care must be individualized and must incorporate a rehabilitative strategy that promotes enhanced recovery of concussion-related symptoms while preventing physical deconditioning. In this review, we present our evolving evidence-based approach to evaluation and management of athletes with PCS that aims to identify the pathophysiological mechanisms mediating persistent concussion symptoms and guides the initiation of individually tailored rehabilitation programs that target these processes. In addition, we outline the important qualified roles that multi-disciplinary healthcare professionals can play in the management of this patient population, and discuss where future research efforts must be focused to further evaluate this evolving pathophysiological approach.

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“…монозиготных близнецов по сравнению с дизиготными [9,10]. Больший риск наследования мигрени отмечается у родственников пациентов с ранним началом мигрени и тяжелым течением приступов [11][12][13].…”

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Genetic aspects of migraine

Kopishinskaya¹,

Густов²

2015

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Migraine is a common disease characterized by severe headache with nausea, vomiting and hypersensitivity to sounds, light, smell. Neurological symptoms during aura period develop in 25% of patients. Genes responsible for migraine development have been identified. The mutations in familial hemiplegic migraine are better investigated. The serotonin system plays a key role in the migraine pathogenesis. It was described the syndrome of migraine-like headache occurring due impaired serotonin metabolism in patients with celiac disease. Celiac disease is a chronic polysyndrome disease, enteropathy. Arteriopathies associated with migraine are cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (syndrome CADASIL), retinal vasculopathy with cerebral leukodystrophy (RVCL), hereditary systemic angiopathy (HSA), mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS).

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Genetics of migraine headache in children

Cited by 7 publications

References 41 publications

Spontaneous Trigeminal Allodynia in Rats: A Model of Primary Headache

Spontaneous Trigeminal Allodynia in Rats: A Model of Primary Headache

Multi-Disciplinary Management of Athletes with Post-Concussion Syndrome: An Evolving Pathophysiological Approach

Genetic aspects of migraine

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