A giant magnetoimpedance-based separable-type method for supersensitive detection of 10 magnetic beads at high frequency

Wang, Tao; Chen, Yu-Yi; Wang, Bicong; He, Yi; Li, Hengyu; Liu, Mei; Rao, Jinjun; Wu, Zhizheng; Xie, Shaorong; Luo, Jun

doi:10.1016/j.sna.2019.111656

Cited by 15 publications

(17 citation statements)

References 40 publications

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“…A popular structure that incorporates these findings is FeNi/Cu/FeNi sandwich films, where Cu separates FeNi multilayers and serves as the central conductive spacer [ 76 ]. Including an insulator between the metallic and ferromagnetic layers has also been shown to further increase this effect as a consequence of changing the distribution of the electromagnetic field in the film to promote a change in impedance upon the application of an external field [ 77 ]. Kurlyandskaya et al reported that the closer the conductivity of the spacer to that of the film, the more evenly distributed the electromagnetic field will be, which is conducive to a larger MI effect in the material [ 69 ].…”

Section: Current Magnetoimpedance Biosensors and Healthcare Monitors ...mentioning

confidence: 99%

“…Additionally, the AC magnetic field may prove useful in magnetizing any magnetic particles near the film. This is particularly important when working with superparamagnetic nanoparticles, where the magnetization process may allow for the detection of these particles without the necessity of an external magnetizing field [ 77 ]. An additional parameter that may also be studied is the operating current of the sensors, which has been shown to impact sensor sensitivity ( Figure 7 f–h).…”

Section: Current Magnetoimpedance Biosensors and Healthcare Monitors ...mentioning

confidence: 99%

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Magnetoimpedance Biosensors and Real-Time Healthcare Monitors: Progress, Opportunities, and Challenges

et al. 2022

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A small DC magnetic field can induce an enormous response in the impedance of a soft magnetic conductor in various forms of wire, ribbon, and thin film. Also known as the giant magnetoimpedance (GMI) effect, this phenomenon forms the basis for the development of high-performance magnetic biosensors with magnetic field sensitivity down to the picoTesla regime at room temperature. Over the past decade, some state-of-the-art prototypes have become available for trial tests due to continuous efforts to improve the sensitivity of GMI biosensors for the ultrasensitive detection of biological entities and biomagnetic field detection of human activities through the use of magnetic nanoparticles as biomarkers. In this review, we highlight recent advances in the development of GMI biosensors and review medical devices for applications in biomedical diagnostics and healthcare monitoring, including real-time monitoring of respiratory motion in COVID-19 patients at various stages. We also discuss exciting research opportunities and existing challenges that will stimulate further study into ultrasensitive magnetic biosensors and healthcare monitors based on the GMI effect.

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Section: Current Magnetoimpedance Biosensors and Healthcare Monitors ...mentioning

confidence: 99%

Section: Current Magnetoimpedance Biosensors and Healthcare Monitors ...mentioning

confidence: 99%

Magnetoimpedance Biosensors and Real-Time Healthcare Monitors: Progress, Opportunities, and Challenges

et al. 2022

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“…Researchers have developed a sensitive GMR-based sensor with NiFe/Cu/NiFe/Cu/Cr films for detecting magnetic particles [ 132 ]. The authors have reported large resistance variations caused by magnetic particles in the frequency range of 30 MHz∼120 MHz.…”

Section: Detection and Characterizationmentioning

confidence: 99%

Microfluidic Synthesis, Control, and Sensing of Magnetic Nanoparticles: A Review

2021

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Magnetic nanoparticles have attracted significant attention in various disciplines, including engineering and medicine. Microfluidic chips and lab-on-a-chip devices, with precise control over small volumes of fluids and tiny particles, are appropriate tools for the synthesis, manipulation, and evaluation of nanoparticles. Moreover, the controllability and automation offered by the microfluidic chips in combination with the unique capabilities of the magnetic nanoparticles and their ability to be remotely controlled and detected, have recently provided tremendous advances in biotechnology. In particular, microfluidic chips with magnetic nanoparticles serve as sensitive, high throughput, and portable devices for contactless detecting and manipulating DNAs, RNAs, living cells, and viruses. In this work, we review recent fundamental advances in the field with a focus on biomedical applications. First, we study novel microfluidic-based methods in synthesizing magnetic nanoparticles as well as microparticles encapsulating them. We review both continues-flow and droplet-based microreactors, including the ones based on the cross-flow, co-flow, and flow-focusing methods. Then, we investigate the microfluidic-based methods for manipulating tiny magnetic particles. These manipulation techniques include the ones based on external magnets, embedded micro-coils, and magnetic thin films. Finally, we review techniques invented for the detection and magnetic measurement of magnetic nanoparticles and magnetically labeled bioparticles. We include the advances in anisotropic magnetoresistive, giant magnetoresistive, tunneling magnetoresistive, and magnetorelaxometry sensors. Overall, this review covers a wide range of the field uniquely and provides essential information for designing “lab-on-a-chip” systems for synthesizing magnetic nanoparticles, labeling bioparticles with them, and sorting and detecting them on a single chip.

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“…In order to detect the presence of MNPs and to quantify their concentration, different types of magnetic sensors have been proposed [5,6]. In particular, the magneto-impedance (MI) effect's extraordinary sensitivity to small magnetic fields has motivated the active development of MI-based biosensors which, fundamentally, detect the presence and concentration of magnetic particles [7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

The Performance of the Magneto-Impedance Effect for the Detection of Superparamagnetic Particles

Garcı́a-Arribas

2020

Sensors

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The performance of magneto-impedance sensors to detect the presence and concentration of magnetic nanoparticles is investigated, using finite element calculations to directly solve Maxwell’s equations. In the case of superparamagnetic particles that are not sufficiently magnetized by an external field, it is assumed that the sensitivity of the magneto-impedance sensor to the presence of magnetic nanoparticles comes from the influence of their magnetic permeability on the sensor impedance, and not from the stray magnetic field that the particles produce. The results obtained not only justify this hypothesis, but also provide an explanation for the discrepancies found in the literature about the response of magneto-impedance sensors to the presence of magnetic nanoparticles, where some authors report an increasing magneto-impedance signal when the concentration of magnetic nanoparticles is increased, while others report a decreasing tendency. Additionally, it is demonstrated that sensors with lower magneto-impedance response display larger sensitivities to the presence of magnetic nanoparticles, indicating that the use of plain, nonmagnetic conductors as sensing materials can be beneficial, at least in the case of superparamagnetic particles insufficiently magnetized in an external magnetic field.

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A giant magnetoimpedance-based separable-type method for supersensitive detection of 10 magnetic beads at high frequency

Cited by 15 publications

References 40 publications

Magnetoimpedance Biosensors and Real-Time Healthcare Monitors: Progress, Opportunities, and Challenges

Magnetoimpedance Biosensors and Real-Time Healthcare Monitors: Progress, Opportunities, and Challenges

Microfluidic Synthesis, Control, and Sensing of Magnetic Nanoparticles: A Review

The Performance of the Magneto-Impedance Effect for the Detection of Superparamagnetic Particles

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