A giant ovarian mucinous tumor in a 58-year-old postmenopausal patient with persistent abdominal pain and high serum levels of CA 19-9

Abstract

Ovarian cancer is the seventh most commonly diagnosed cancer among women in the world and epithelial ovarian cancer is the most predominant pathologic subtype. Tumor markers are widely used in clinical practice to determine therapeutic efficacy, to detect recurrence and to predict prognosis in known cancers. CA-19-9 antigen is mainly elevated in cases of gastrointestinal tract malignancy, including of the pancreas, colorectum, and biliary tract. However, CA 19-9 antigen can also be elevated in ovarian mucinous neoplasms. We report herein the case of a 58-year-old woman who presented with an abnormally high level of CA 19-9 antigen associated with ovarian mucinous borderline tumor.

An enormous pelvic tumor in a 46-year-old woman with an elevated serum CA 125 level, what lies beneath it? Investigation of uterine tumors in postmenopausal women

“…Cancer antigen is mostly used as a relatively specific marker for ovarian cancer. According to the literature, the combination of a pelvic tumor and a high level of CA 125 arouses suspicion of a gynecological malignancy, but other benign conditions such as menstruation, endometriosis, and pelvic inflammatory diseases should always be considered in the differential diagnosis, particularly in pre-menopausal women [ 19 – 21 ]. Although there is limited evidence to support an association between elevated CA 125 levels and uterine fibroids, abnormally high levels have been reported in a small number of patients.…”

Mucinous borderline ovarian tumour with torsion and micro-invasion and associated with high serum level of carbohydrate antigen 19-9: a case report

“…Epithelial ovarian cancers are considered the most common type of ovarian cancer, accounting for about 90% of cases. More than 75% of epithelial ovarian cancers are of the serous type, whereas mucinous, endometrioid, clear cell, Brenner, and undifferentiated lineage types are less common 3 . Failure in early detection can lead to high mortality rate 3 .…”

“…More than 75% of epithelial ovarian cancers are of the serous type, whereas mucinous, endometrioid, clear cell, Brenner, and undifferentiated lineage types are less common 3 . Failure in early detection can lead to high mortality rate 3 .…”

“…Tumour markers have been used widely to determine therapeutic efficacy, detect recurrence, and predict prognosis in known cancers. Markers for ovarian cancer include CA125, CA15-3, CEA, and CA19-9 3 . CA125 contributes to early diagnosis of epithelial ovarian cancers by detecting an antigenic site on MUC16.…”

Gastric-type Mucinous Carcinoma with an Abnormal Increase of CA199: A Case Report and Literature Review

“…Therefore, CA199 can be elevated in many types of gastrointestinal cancer such as colorectal cancer, esophageal cancer, and hepatocellular cancer. Moreover, CA199 antigen can also be elevated in ovarian mucinous neoplasms ( 22 ). For perimenopausal women patients, it is also necessary to make a differentiation with regard to endometrial cancer, uterine fibroids, inflammatory conditions, or diseases other than cancers ( 23 , 24 ).…”