A giant primary cutaneous melanoma of the scalp – can it be that big?

Panajotovic, Ljubomir; Đorđević, Biljana; Pavlović,

doi:10.1111/j.1468-3083.2007.02218.x

Cited by 14 publications

(12 citation statements)

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“…This pattern of local spread without distant disease in such massive melanomas was also noted in several other case reports1 , 4 , 5 found on review of the literature. Conventional sized melanomas are thought to follow a paradigm of orderly disease progression from primary site to regional lymph nodes and subsequently to distant sites 13 – 15.…”

Section: Discussionsupporting

confidence: 84%

“…We and others1 , 2 , 4 – 6 support an attempt at cure with multimodality treatment, including aggressive surgical resection. Even if cure is not achieved, palliative debulking may at least offer symptom control (for example, local infection and bleeding).…”

Section: Discussionmentioning

confidence: 82%

“…A review of the recent literature demonstrates isolated case reports which describe patients who present with giant melanomas of various anatomic sites, including the back,1 , 2 abdomen,3 scalp,4 eyelid5 and thumb 6. To our knowledge, patient B—who had a 19 cm diameter lesion—represents the largest primary melanoma of the upper extremity and one of the largest melanomas of all reported to date.…”

Section: Discussionmentioning

confidence: 99%

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Giant cutaneous melanomas: evidence for primary tumour induced dormancy in metastatic sites?

Tseng¹,

Doyle²,

Maguiness³

et al. 2009

Case Reports

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Two patients with giant, 8 cm and 19 cm melanomas of the upper extremity, respectively, are presented and discussed. Both patients had neglected their tumours and sought medical attention only after the appearance of distressing symptoms (for example, bleeding). Palpable lymph nodes were found on physical examination but no evidence of distant metastases was noted on imaging studies despite such enormous primary tumours. Both patients underwent aggressive treatment, including complete surgical resection of the primary tumour and ipsilateral axillary lymph node dissection. One patient had no evidence of local recurrence, but developed metastatic disease at 6 months follow-up. The other patient developed local recurrence and distant metastases within 2 months of resection.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

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Giant cutaneous melanomas: evidence for primary tumour induced dormancy in metastatic sites?

Tseng¹,

Doyle²,

Maguiness³

et al. 2009

Case Reports

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“…Large melanoma masses have rarely been reported in the literature, mainly because patients tend to come for treatment early before the tumor enlarges and practitioners are well aware of the catastrophic consequences of neglecting such tumors 1 . In the available literature, we found ten reports of malignant melanoma that presented as a giant mass [1][2][3][4][5][6][7][8][9][10] . Of these, three cases were nodular melanomas [1][2][3] , two were giant congenital melanocytic nevi 4,5 and one was a metastatic melanoma 6 .…”

Section: Discussionmentioning

confidence: 99%

Giant Acral Melanoma on the Left Thumb of a Korean Patient

et al. 2009

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Department of Dermatology, College of Medicine, Korea University, Seoul, KoreaThe acral regions of the limbs of Asians are predisposed to develop malignant melanoma, but giant-sized acral melanoma has not been previously reported in the Asian population. Giant-sized melanoma implies aggressive tumor invasion and so it is more difficult to achieve a therapeutic cure. A 56-year-old woman presented with a giant acral melanoma of the left thumb with concomitant bone destruction and axillary lymph node metastasis. The initial lesion was a subungual black macule on the left thumb that had grown into a giant 7.0×4.0×3.5 cm-sized melanoma over a 3 year period. The left thumb was amputated and the axillary lymph nodes were completely dissected. During the ensuing 3 months, she underwent adjuvant treatment with interferon-alpha-2a. The interesting feature of this case is that the large melanoma mass of this patient, which was accompanied with adjacent bone destruction and lymph node metastasis, had developed rapidly from a small black macule in the nail matrix, and this black macule was suspected to be a subungual melanoma.

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“…Two of the three patients with a giant scalp melanoma in the literature presented with a vegetative tumor, and the other one presented with confluent purple-blue-gray macules, papules and nodules as in our patient (1,3,4).…”

Section: To the Editormentioning

confidence: 99%

Giant Scalp Melanoma

Böyük

2016

Osmangazi̇ Journal of Medicine

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A 54-year-old female presented with a 4-month history of extensive dark-colored lesions on her scalp. The pathology result of a previous biopsy from her scalp performed by a general surgeon a year ago had been congenital melanocytic nevus. Dermatological examination showed confluent blue-grey, dark brown macules, papules and nodules covering most of the left parietofrontotemporal scalp in an area measuring 15x30 cm in size ( Figure 1a). There were also satellite lesions of varying diameters on the ear, anterior trunk and one pigmented lesion of the oral mucosa. Dermoscopic analysis of the lesions revealed asymmetry of color and structure, multicomponent global pattern, irregular dots and globules and bluish-white color ( Figure 1b).Histopathologic examination of three 4-mm punch biopsies from the patient's scalp revealed atypical melanocytic lesions with findings that were not adequate to confirm melanoma. Total excision of the scalp lesion was not approved by plastic surgery. The total excision material of the pigmented lesion on her anterior trunk was referred to another pathologist and revealed superficial spreading melanoma with Breslow thickness of 1 mm, Clark level of 3 and mitotic rate of 2/mm² (Figure 1c). In addition, pulmonary metastases were detected by total body positron emission tomography-computed tomography (PET-CT). The case was accepted as T1N3M1 inoperable metastatic malign melanoma originating from the scalp lesion. Vemurafenib treatment was started by medical oncology. However, the patient developed nodules and ulcerations, cervical lymph node metastasis and vena cava superior syndrome during the treatment and died nine months after the diagnosis.

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A giant primary cutaneous melanoma of the scalp – can it be that big?

Abstract: wounds. In particular, the extended time of contact with the wound by using a non-cytotoxic hydrogel preparation and the simple handling can represent a crucial therapy advantage compared to other therapy options.

Cited by 14 publications

References 0 publications

Giant cutaneous melanomas: evidence for primary tumour induced dormancy in metastatic sites?

Giant cutaneous melanomas: evidence for primary tumour induced dormancy in metastatic sites?

Giant Acral Melanoma on the Left Thumb of a Korean Patient

Giant Scalp Melanoma

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