A giant solitary fibrous tumor of the adrenal gland in a 13-year old: a case report and review of the literature

Gebresellassie, Hailu Wondimu; Mohammed, Yusuf; Kotiso, Brahenu; Amare, Bereket; Kebede, Aemero

doi:10.1186/s13256-019-2163-z

Cited by 6 publications

(3 citation statements)

References 7 publications

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“…SFT is a rare neoplasm of mesenchymal origin, most commonly originating from the pleura[ 6 ]. However, it can occur in multiple parts of the body, including the meninges[ 7 ], spine[ 8 ], pancreas[ 9 ], pelvis[ 10 ], adrenal gland[ 11 ] and liver[ 12 ]. SFT of the liver is extremely rare, 84 cases reported in the literature from 1958 to 2016 according to a review by Chen and Slater[ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Solitary fibrous tumor of the liver: A case report and review of the literature

Xie¹,

Zhu²,

Yun³

et al. 2022

WJCC

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Solitary fibrous tumor (SFT) is a rare mesenchymal tumor. Given its origin, it can appear in almost any location. In the literature, only 50 cases of SFT in the liver parenchyma have been reported. Despite its rarity, this entity should be included in the differential diagnosis of liver masses. We report the first case with imaging data from five years prior to diagnosis, which was treated by right portal embolization and arterial tumor embolization, and subsequent liver resection. We also present an exhaustive review of the cases described to date.

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Section: Discussionmentioning

confidence: 99%

Solitary fibrous tumor of the liver: A case report and review of the literature

Xie¹,

Zhu²,

Yun³

et al. 2022

WJCC

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“…They are usually diagnosed in the fifth to seventh decade of life [16,17]. SFTs are not commonly found in pediatric patients, but cases in children [18][19][20][21][22][23][24] and infants [25,26] have also been described. Furthermore, tumors located in the pleura occur later in life, in contrast to other anatomical sites [27].…”

Section: Epidemiologymentioning

confidence: 99%

Diagnostics and Treatment of Extrameningeal Solitary Fibrous Tumors

Janik,

Terlecka,

Spałek

et al. 2023

Cancers

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Solitary fibrous tumors (SFT) are rare mesenchymal neoplasms that account for less than 2% of all soft tissue masses. In the latest WHO 2020 Classification of Soft Tissue Tumors, extrameningeal SFT was listed as intermediate (rarely metastasizing) or malignant neoplasms. Due to the lack of characteristic clinical features, their diagnosis and treatment remain challenging. The pathogenesis of SFT is often associated with the presence of fusions of the NAB2-STAT6 gene on the 12q13 chromosome. Cytoplasmic CD34 positive staining is considerably characteristic for most SFTs; less frequently, factor XII, vimentin, bcl-2, and CD99 are present. A key factor in the diagnosis is the prevalent nuclear location of STAT6 expression. Radical resection is the mainstay of localized SFTs. In the case of unresectable disease, only radiotherapy or radio-chemotherapy may significantly ensure long-term local control of primary and metastatic lesions. To date, no practical guidelines have been published for the treatment of advanced or metastatic disease. Classical anthracycline-based chemotherapy is applicable. The latest studies suggest that antiangiogenic therapies should be considered after first-line treatment. Other drugs, such as imatinib, figitumumab, axitinib, and eribulin, are also being tested. Definitive radiotherapy appears to be a promising therapeutic modality. Since standards for the treatment of advanced and metastatic diseases are not available, further investigation of novel agents is necessary.

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“…In the adrenal gland, a primary occurrence of solitary fibrous tumor had only been documented eleven times in the English literature [10][11][12][13][14][15][16][17][18][19][20] (Table 1).…”

Section: Discusionmentioning

confidence: 99%

Solitary Fibrous Tumor of Adrenal Gland and Review of the Literature

Ambardjieva

Saidi

Jovanović

et al. 2021

Prilozi

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Solitary fibrous tumor (SFT) is a rare and still controversial entity. This type of tumor first appeared in the literature as a pleural lesion, but, over the last decades, it has been reported in many extrathoracic sites. As a tumor of the adrenal gland, SFT is still rare and very uncommon, thus extensive research among the English language literature has been performed. We present here a case report of an adrenal SFT which is compared to 11 other known cases. Our case report is from a patient with SFT on the left adrenal gland, followed by mild symptoms of abdominal discomfort and hypertension. Physical examination, laboratory, and radiological tests were performed. The patient underwent surgery and the material was sent for histopathologic analysis for a definite diagnosis. Regular follow up appointments were performed over the course of two years. No recurrence of the tumor has been detected. We explain the symptoms, diagnosis, treatment, and additionally we describe the results and implications of the findings reported in the literature. Correct diagnosis is mandatory for optimal management of solitary fibrous tumor patients.

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A giant solitary fibrous tumor of the adrenal gland in a 13-year old: a case report and review of the literature

Cited by 6 publications

References 7 publications

Solitary fibrous tumor of the liver: A case report and review of the literature

Solitary fibrous tumor of the liver: A case report and review of the literature

Diagnostics and Treatment of Extrameningeal Solitary Fibrous Tumors

Solitary Fibrous Tumor of Adrenal Gland and Review of the Literature

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