A ginseng saponin metabolite suppresses tumor necrosis factor-α-promoted metastasis by suppressing nuclear factor-κB signaling in murine colon cancer cells

Choo, Min‐Kyung; Sakurai, Hiroaki; Kim, Dong-Hyun; Saiki, Ikuo

doi:10.3892/or.19.3.595

Cited by 63 publications

(79 citation statements)

References 24 publications

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“…Meanwhile, two PI3K inhibitors (wortmannin and LY294002) significantly suppressed the phagocytic uptake of FITC-dextran (Fig. 6B), as reported previously (Choo et al, 2008). Recently, immunosuppressive effects of ginsenosides or their metabolites such as compound K, G-Rh1, G-Rb1, G-Rb2, G-Rh2, and 20(S)-protopanaxatriol have been reported.…”

Section: Resultssupporting

confidence: 55%

Inhibitory Effect of Ginsenoside-Rp1, a Novel Ginsenoside Derivative, on the Functional Activation of Macrophage-like Cells

Park¹,

Cho²

2008

Biomolecules and Therapeutics

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− Ginsenoside Rp1 (G-Rp1) is a ginseng saponin derivative with chemopreventive and anti-cancer activities. In this study, we examined the regulatory activity of G-Rp1 on the functional activation of macrophages. G-Rp1 remarkably inhibited TNF-α production, LPS-induced cell cytotoxicity, NO production, ROS generation, and phagocytic uptake from lipopolysacchride (LPS)-activated RAW264.7 cells. According to structural feature study using several G-Rp1 analogs, two carbohydrates (glucose-glucose) at R1 position were observed to be highly effective, compared to other structural derivatives. Although the inhibitory activities of G-Rp1 on macrophage functions were not remarkable, several points that G-Rp1 was known to be safe, and that this compound was orally effective, suggest that G-Rp1 may be beneficial in treating macrophage-mediated immunological diseases.

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Section: Resultssupporting

confidence: 55%

Inhibitory Effect of Ginsenoside-Rp1, a Novel Ginsenoside Derivative, on the Functional Activation of Macrophage-like Cells

Park¹,

Cho²

2008

Biomolecules and Therapeutics

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“…It can be induced by NF-B (82). SC-514, an inhibitor of IKK, blocks the TNF--induced activation of NF-B as well as the expression of matrix metalloprotease-9 (MMP-9), migration and invasion of murine colon adenocarcinoma cells (83).…”

Section: The Role Of Nf-b In Promoting Carcinogenesis Of Colorectal mentioning

confidence: 99%

NF-κB Signaling Pathway, Inflammation and Colorectal Cancer

et al. 2009

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There is growing evidence for a connection between inflammation and tumor development, and the nuclear factor kappa B (NF-B), a proinflammatory transcription factor, is hypothesized to promote tumorigenesis. Although the genetic evidence for the hypothesis has been lacking, recent papers have lent credence to this hypothesis. It has been reported that constitutive NF-B activation in inflammatory bowel diseases (

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“…26 The tubing was placed into 100 mL of dialysis medium containing 0.5% Tween 80 and stirred at 100 rpm/min at 37°C (pH =7.4). One milliliter of the release medium was removed and the same volume of fresh buffer was added at 0, 1, 2, 3, 4,6,8,20,24, and 48 h. The concentration of CK in CK-M at each time point was determined using HPLC. All measurements were performed in triplicate.…”

Section: Drug Content and Entrapment Efficiencymentioning

confidence: 99%

“…[4][5][6] CK acts by various antitumor mechanisms including inhibition of tumor cell proliferation, promotion of tumor cell apoptosis, and inhibition of tumor cell invasion and metastasis. 7,8 Although appreciable antitumor activity of CK has been reported, its poor water solubility and strong efflux greatly reduce the efficacy of CK. 9 In recent years, various nanodelivery systems, such as CK-bearing glycol chitosan conjugates and PEG-CK, have been used to improve the limitations associated with CK.…”

Section: Introductionmentioning

confidence: 99%

Targeted delivery of ginsenoside compound K using TPGS/PEG-PCL mixed micelles for effective treatment of lung cancer

Yang

Zhang

Hou

et al. 2017

IJN

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Ginsenoside compound K (CK) is one of the effective ingredients in antitumor composition of ginsenoside. However, the poor water solubility and significant efflux have limited the widespread clinical use of CK. In this study, preparation of novel CK-loaded d -alpha-tocopheryl polyethylene glycol 1,000 succinate/poly(ethylene glycol)-poly(ε-caprolactone) mixed micelles (CK-M) is discussed to solve the above problems. Particle size, zeta potential, and morphology were characterized using dynamic light scattering and transmission electron microscopy. CK-M are spherical shaped with an average particle size of 53.07±1.31 nm with high drug loading of 11.19%±0.87% and entrapment efficiency of 94.60%±1.45%. Water solubility of CK was improved to 3.78±0.09 mg/mL, which was ~107.35 times higher than free CK. A549 and PC-9 cells were used to evaluate in vitro cytotoxicity and cellular uptake. IC 50 values of CK-M in A549 and PC-9 cells (24 h) were 25.43±2.18 and 18.35±1.90 μg/mL, respectively. Enhanced cellular uptake of CK-M was observed in both cells. Moreover, CK-M promoted tumor cell apoptosis, inhibited tumor cell invasion, metastasis, and efflux through regulation of Bax, Bcl-2, matrix metalloproteinase-2, Caspase-3, and P-glycoprotein. In vivo imaging indicated that CK-M has excellent tumor targeting effect within 24 h, and the relative tumor inhibition rate of CK-M was 52.04%±4.62% compared with control group ( P <0.01). Thus, CK-M could be an appropriate delivery agent for enhanced solubility and antitumor effect of CK.

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A ginseng saponin metabolite suppresses tumor necrosis factor-α-promoted metastasis by suppressing nuclear factor-κB signaling in murine colon cancer cells

Cited by 63 publications

References 24 publications

Inhibitory Effect of Ginsenoside-Rp1, a Novel Ginsenoside Derivative, on the Functional Activation of Macrophage-like Cells

Inhibitory Effect of Ginsenoside-Rp1, a Novel Ginsenoside Derivative, on the Functional Activation of Macrophage-like Cells

NF-κB Signaling Pathway, Inflammation and Colorectal Cancer

Targeted delivery of ginsenoside compound K using TPGS/PEG-PCL mixed micelles for effective treatment of lung cancer

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