Information processing
by traditional, serial electronic processors
consumes an ever-increasing part of the global electricity supply.
An alternative, highly energy efficient, parallel computing paradigm
is network-based biocomputation (NBC). In NBC a given combinatorial
problem is encoded into a nanofabricated, modular network. Parallel
exploration of the network by a very large number of independent molecular-motor-propelled
protein filaments solves the encoded problem. Here we demonstrate
a significant scale-up of this technology by solving four instances
of Exact Cover, a nondeterministic polynomial time (NP) complete problem
with applications in resource scheduling. The difficulty of the largest
instances solved here is 128 times greater in comparison to the current
state of the art for NBC.