A Glucose Sensor Based on an Organic Electrochemical Transistor Structure Using a Vapor Polymerized Poly(3,4-ethylenedioxythiophene) Layer

Kim, Yuna; Do, Jaekwon; Kim, Jeong-Hun; Yang, Sang Yoon; Malliaras, George G.; Ober, Christopher K.; Kim, Eunkyoung

doi:10.1143/jjap.49.01ae10

Cited by 31 publications

(32 citation statements)

References 24 publications

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“…Malliaras's group62, 86–95 has systematically investigated the OECTs for sensing applications. Zhu et al86 demonstrated a simple glucose sensor based on OECT at neutral pH.…”

Section: Sensors Based On Oectsmentioning

confidence: 99%

Organic Thin‐Film Transistors for Chemical and Biological Sensing

2011

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Organic thin-film transistors (OTFTs) show promising applications in various chemical and biological sensors. The advantages of OTFT-based sensors include high sensitivity, low cost, easy fabrication, flexibility and biocompatibility. In this paper, we review the chemical sensors and biosensors based on two types of OTFTs, including organic field-effect transistors (OFETs) and organic electrochemical transistors (OECTs), mainly focusing on the papers published in the past 10 years. Various types of OTFT-based sensors, including pH, ion, glucose, DNA, enzyme, antibody-antigen, cell-based sensors, dopamine sensor, etc., are classified and described in the paper in sequence. The sensing mechanisms and the detection limits of the devices are described in details. It is expected that OTFTs may have more important applications in chemical and biological sensing with the development of organic electronics.

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“…Malliaras's group62, 86–95 has systematically investigated the OECTs for sensing applications. Zhu et al86 demonstrated a simple glucose sensor based on OECT at neutral pH.…”

Section: Sensors Based On Oectsmentioning

confidence: 99%

Organic Thin‐Film Transistors for Chemical and Biological Sensing

2011

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“…Vapor-phase polymerization (VPP) has also been successfully used for the fabrication of OECTs-based glucose sensors by Kim et al [120] As reported in this paper, the authors prepared an oxidant solution containing Fe(III)-tosylate (dissolved in isopropyl alcohol) and spin-coated it on a glass substrate. The substrate was then placed inside a polymerization chamber containing a hot plate filled with a small amount of a 3,4-ethylenedioxythiophene (EDOT) solution.…”

Section: In-situ Polymerizationmentioning

confidence: 99%

Fabrication and Use of Organic Electrochemical Transistors for Sensing of Metabolites in Aqueous Media

et al. 2018

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Featured Application: Sensing organic molecules in water.Abstract: This review first recalls the basic functioning principles of organic electrochemical transistors (OECTs) then focuses on the transduction mechanisms applicable to OECTs. Materials constituting the active semiconducting part are reviewed, from the historical conducting polymers (polyaniline, polypyrrole) to the actual gold standard, poly-3,4-ethylenedioxythiophene: polystyrene sulfonic acid (PEDOT:PSS), as well as the methods used to fabricate these transistors. The review then focuses on applications of OECTs for the detection of small molecules and more particularly of metabolites, with a distinction between enzymatic and non-enzymatic transduction pathways. Finally, the few patents registered on the topic of OECT-based biosensors are reviewed, and new tracks of improvement are proposed. applied to biosensing quite early, associated with enzymes [4][5][6]. This is because, due to their functioning mechanism (already identified at the time), they brought into play the same charge carriers as most biological functions, i.e., electrons but also ions, and were therefore sensitive both to electron transfer to/from redox enzymes or ions (e.g., protons) produced from other types of enzymes. This is a characteristic which distinguished them from organic field-effect transistors (OFETs), which started to raise the attention of researchers exactly at the same period (precisely, 1983 for the first polyacetylene-based OFET [7]), and a few years later for applications to gas sensing (halogens, ammonia, oxygen [8-10] or even vapors of H 2 O, NO or H 2 O 2 [11][12][13][14]). However, OFETs never really produced any applicable results in the framework of biosensors in aqueous environment because of high operating voltages, of several tens of volts, which impede any measurements because of water electrolysis. Ion-sensitive organic field-effect transistors (ISOFETs), based on the same working principles of their inorganic counterparts (ISFETs) developed earlier [15,16], solved this problem of high operating potential, the electrolyte being not in direct contact with the semiconductor. However, these devices were confined mostly to protons detection [17][18][19] or, in any case, to charged species.As we show in this review, OECTs use both potentiometry and amperometry in their working principles. In that sense, OECTs are devices that represent a bridge between ISOFETs and classical amperometry, which certainly explains their success. This area of research is very active and several reviews have already been published on OECTs in general, for example by Kergoat et al. [1] or Rivnay et al. [3], or on OECTs applied to biology, for example by Liao and Yan [20], Liao et al. [21], Strakosas et al. [22] or . This present review, after going back to the basic functioning principles, along with details on transductions applicable to OECTs, reviews materials, fabrication techniques and then sensing applications. We focus on the detection of small molecules and more part...

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“…Conducting polymer-based sensors can be classified by the nature of their detection methods such as amperometric, conductometric, chemiresistive, and others. 6,116 VPP conductive polymer films were first used for detecting 3 mM concentrations of alcohols (C 2 -C 4 ) by using patterned poly(3,3 0 -dipentoxy-2,2 0 -bithiophene) on nonconductive substrates like glass and surface oxidized silicon wafers. An increase in conductivity was detected in less than 5 s for all alcohols tested, and responses were observed to decrease as the chain length of the alcohol increased.…”

Section: Electrochromic Devicesmentioning

confidence: 99%

“…118 An amperometric glucose sensor based on VPP PEDOT was demonstrated, which showed a linear relationship between the response against micro-to mili-molar Figure 21(b). 116 Chemiresistive sensing properties of conductive polymers can be improved by covalent immobilization of an analyte specific molecule to the conducting polymer matrices. For example, direct analysis of the changes in the work functions of metal nanoparticles when exposed to a vapor is very difficult.…”

Section: Electrochromic Devicesmentioning

confidence: 99%

Vapor phase oxidative synthesis of conjugated polymers and applications

Bhattacharyya

Howden

Borrelli

et al. 2012

J Polym Sci B Polym Phys

116

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Since their discovery, electrically conductive polymers have gained immense interest both in the fields of basic and applied research. Despite their vast potential in the fabrication of efficient, flexible, and low-cost electronic and optoelectronic devices, they are often difficult to process by wetchemical methods due to their very low to poor solubility in organic solvents. The use of vapor-based synthetic routes, in which conductive polymers can be synthesized and deposited as a thin film directly on a substrate from the vapor phase, provides many unique advantages. This article discusses oxidative vapor deposition processes, primarily vapor phase polymerization and oxidative chemical vapor deposition, of conjugated polymers and their applications. The mild operating conditions (near room temperature processing) allow conformal and functional coatings of conjugated polymers on delicate substrates.

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A Glucose Sensor Based on an Organic Electrochemical Transistor Structure Using a Vapor Polymerized Poly(3,4-ethylenedioxythiophene) Layer

Cited by 31 publications

References 24 publications

Organic Thin‐Film Transistors for Chemical and Biological Sensing

Organic Thin‐Film Transistors for Chemical and Biological Sensing

Fabrication and Use of Organic Electrochemical Transistors for Sensing of Metabolites in Aqueous Media

Vapor phase oxidative synthesis of conjugated polymers and applications

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