A Glycosaminoglycan-Rich Fraction from Sea Cucumber Isostichopus badionotus Has Potent Anti-Inflammatory Properties In Vitro and In Vivo

Olivera‐Castillo, Leticia; Grant, George; Kantún-Moreno, Nuvia; Barrera-Perez, Hirian Alonso Moshe; Montero, Jorge; Olvera‐Novoa, Miguel A.; Carrillo-Cocom, Leydi Maribel; Acevedo-Fernández, Juan José; Puerto-Castillo, Cesar; Solís, Victor May; Pérez-Vega, Juan Antonio; Gil-Zamorano, Judit; Hernández-Garibay, Enrique; Fernández-Herrera, María A.; Pérez-Tapia, Mayra; Medina-Contreras, Óscar; Villanueva-Toledo, Jairo; Rodríguez-Canul, Rossanna; Dávalos, Alberto

doi:10.3390/nu12061698

Cited by 20 publications

(20 citation statements)

References 43 publications

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“…Overall, the functional metabolic profile of wild I. badionotus from Yucatan is comparable with that of A. japonicus and other captured species. Recent studies have also shown that I. badionotus contains bioactive factors, such as glycosaminoglycans, peptides, saponins, and lectins, which have health-modulating properties comparable to those products from other sea cucumber species [ 2 , 3 , 29 , 30 ]. Therefore, I. badionotus from Yucatan is a proper alternative to traditionally used sea cucumber species.…”

Section: Discussionmentioning

confidence: 99%

Comparative Transcriptomes of the Body Wall of Wild and Farmed Sea Cucumber Isostichopus badionotus

Martín‐Hernández

Rodríguez-Canul²,

Kantún-Moreno³

et al. 2021

IJMS

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Overfishing of sea cucumber Isostichopus badionotus from Yucatan has led to a major population decline. They are being captured as an alternative to traditional species despite a paucity of information about their health-promoting properties. The transcriptome of the body wall of wild and farmed I. badionotus has now been studied for the first time by an RNA-Seq approach. The functional profile of wild I. badionotus was comparable with data in the literature for other regularly captured species. In contrast, the metabolism of first generation farmed I. badionotus was impaired. This had multiple possible causes including a sub-optimal growth environment and impaired nutrient utilization. Several key metabolic pathways that are important in effective handling and accretion of nutrients and energy, or clearance of harmful cellular metabolites, were disrupted or dysregulated. For instance, collagen mRNAs were greatly reduced and deposition of collagen proteins impaired. Wild I. badionotus is, therefore, a suitable alternative to other widely used species but, at present, the potential of farmed I. badionotus is unclear. The environmental or nutritional factors responsible for their impaired function in culture remain unknown, but the present data gives useful pointers to the underlying problems associated with their aquaculture.

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Section: Discussionmentioning

confidence: 99%

Comparative Transcriptomes of the Body Wall of Wild and Farmed Sea Cucumber Isostichopus badionotus

Martín‐Hernández

Rodríguez-Canul²,

Kantún-Moreno³

et al. 2021

IJMS

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“…In contrast with the highly heterogeneous fucoidan from brown algae, this polysaccharide has a regular repetitive structure containing mostly 2,4 disulfated fucose units, as shown in Figure 1 c. When tested on an experimental model of colitis induced by dextran sulfate, oral fucCS attenuated the body weight loss, expression of colonic TNF-α gene and colon shortening caused by experimental colitis. The authors proposed that this protective effect might be due to downregulation of NF-kB and downstream genes such as COX-2 and TNF-α and a benefic profile on gut microbiota [ 49 ].…”

Section: Immunomodulatory Effectmentioning

confidence: 99%

Pharmacological Activities of Sulfated Fucose-Rich Polysaccharides after Oral Administration: Perspectives for the Development of New Carbohydrate-Based Drugs

Fonseca

Mourāo

2021

Marine Drugs

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Marine organisms are a source of active biomolecules with immense therapeutic and nutraceutical potential. Sulfated fucose-rich polysaccharides are present in large quantities in these organisms with important pharmacological effects in several biological systems. These polysaccharides include sulfated fucan (as fucoidan) and fucosylated chondroitin sulfate. The development of these polysaccharides as new drugs involves several important steps, among them, demonstration of the effectiveness of these compounds after oral administration. The oral route is the more practical, comfortable and preferred by patients for long-term treatments. In the past 20 years, reports of various pharmacological effects of these polysaccharides orally administered in several animal experimental models and some trials in humans have sparked the possibility for the development of drugs based on sulfated polysaccharides and/or the use of these marine organisms as functional food. This review focuses on the main pharmacological effects of sulfated fucose-rich polysaccharides, with an emphasis on the antidislipidemic, immunomodulatory, antitumor, hypoglycemic and hemostatic effects.

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“…In vivo anti-inflammatory properties • Attenuation of tissue damage and inflammation was observed Mitigation of colonic colitis due arose due to dextran sodium sulphate(Olivera-Castillo et al, 2020) …”

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confidence: 99%

Structural characterisation, biological activities and pharmacological potential of glycosaminoglycans and oligosaccharides: a review

Sharma

Kataria

Sharma

et al. 2021

Int J of Food Sci Tech

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Carbohydrates are the potential food components holding prime significance in biological functionality and technological performance of food products. They are predominant sources of energy requirement for human body and more recently, they have been explored for their nutraceutical properties and pharmacological effects. The objective of the present article was to critically examine and document up-to-date literature for biological activities and health benefits of two functional carbohydrates groups, that is, glycosaminoglycans and oligosaccharides. Glycosaminoglycans are polymeric forms of sulphated/nonsulphated glycans while oligosaccharides studied in the present article were galacto-oligosaccharides, fructo-oligosaccharides and xylo-oligosaccharides. These two carbohydrate classes have been classified on a structural basis which dictates their unique biological properties. Attributing to their compositional and structural features, they have been found to exhibit several pharmacological properties including prebiotic potential, wound healing, antioxidant potential, immunomodulatory effects and prevention against several other degenerative diseases. Significant emphasis has been given to the structural characterisation and bio-functionality of these polysaccharides in addition to their sources and extraction mechanisms.

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A Glycosaminoglycan-Rich Fraction from Sea Cucumber Isostichopus badionotus Has Potent Anti-Inflammatory Properties In Vitro and In Vivo

Cited by 20 publications

References 43 publications

Comparative Transcriptomes of the Body Wall of Wild and Farmed Sea Cucumber Isostichopus badionotus

Comparative Transcriptomes of the Body Wall of Wild and Farmed Sea Cucumber Isostichopus badionotus

Pharmacological Activities of Sulfated Fucose-Rich Polysaccharides after Oral Administration: Perspectives for the Development of New Carbohydrate-Based Drugs

Structural characterisation, biological activities and pharmacological potential of glycosaminoglycans and oligosaccharides: a review

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