A GPx-mimetic copper vanadate nanozyme mediates the release of nitric oxide from<i>S</i>-nitrosothiols

Ghosh, Satadal; Roy, Punarbasu; Prasad, S. M.; Mugesh, Govindasamy

doi:10.1039/d1fd00067e

Cited by 10 publications

(10 citation statements)

References 68 publications

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“…Typical examples are the GPx-like catalytic reactions of CuV 2 O 6 with GSH and H 2 O 2 , which differ greatly from the previously reported V 2 O 5 nanowires. 51 As shown in Fig. 2A and B, the absence of peaks at 1150 cm −1 and 930-940 cm −1 in Raman and infrared spectra indicated that no V-peroxide species formed.…”

Section: Qiaochu Zhangmentioning

confidence: 77%

“…A detailed study based on experiments and theoretical calculations found that the {010} and {100} facets were more active than {001} because of their unsaturated surfaces, with {010} being the most active. Following these pioneering studies, other V-based nanomaterials, such as V 2 C MXenzyme, 47,80 orthovanadate NP, 81,82 MIL-47(V) MOF, 48 VN 4 single-atom, 83 MnV 2 O 6 , 51 ZnV 2 O 6 , 51 and CuV 2 O 6 , 51 also exhibited excellent GPx-like activities. As shown in Fig.…”

Section: Vanadium-basedmentioning

confidence: 98%

“…As with manganese oxides, copper oxides also exhibited GPxlike properties. 51,[90][91][92][93][94] As an example, a Cu x O nanozyme as a GPx mimic was synthesized with phenylalanine (Phe). 90 The reaction of Cu(II) ions, Phe, and PVP took place at 120 °C, and then partial reduction with glucose was conducted to create Cu x O (Fig.…”

Section: Copper-basedmentioning

confidence: 99%

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Glutathione peroxidase-like nanozymes: mechanism, classification, and bioapplication

et al. 2023

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Section: Qiaochu Zhangmentioning

confidence: 77%

Section: Vanadium-basedmentioning

confidence: 98%

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Glutathione peroxidase-like nanozymes: mechanism, classification, and bioapplication

et al. 2023

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“…[51] In addition, researchers have also synthesized many nanozymes with GPx-like activities, which can convert endogenous prodrugs (e.g., S-nitrosoglutathione, GSNO) to NO. [52][53][54][55] Weng et al made a polydopamine coating containing HKUST-1 MOF on stainless steel to mimic the function of ECs. They found that the HKUST-1 MOF coating could catalyze GSNO decomposition to generate NO, similar to natural enzymes.…”

Section: No Generationmentioning

confidence: 99%

“…[ 51 ] In addition, researchers have also synthesized many nanozymes with GPx‐like activities, which can convert endogenous prodrugs (e.g., S‐nitrosoglutathione, GSNO) to NO. [ 52–55 ] Weng et al. made a polydopamine coating containing HKUST‐1 MOF on stainless steel to mimic the function of ECs.…”

Section: No Generationmentioning

confidence: 99%

Nanozyme‐Enabled Treatment of Cardio‐ and Cerebrovascular Diseases

Zhang

Liu

Wang

et al. 2022

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Cardio‐ and cerebrovascular diseases are two major vascular‐related diseases that lead to death worldwide. Reactive oxygen species (ROS) play a vital role in the occurrence and exacerbation of diseases. Excessive ROS induce cellular context damage and lead to tissue dysfunction. Nanozymes, as emerging enzyme mimics, offer a unique perspective for therapy through multifunctional activities, achieving essential results in the treatment of ROS‐related cardio‐ and cerebrovascular diseases by directly scavenging excess ROS or regulating pathologically related molecules. This review first introduces nanozyme‐enabled therapeutic mechanisms at the cellular level. Then, the therapies for several typical cardio‐ and cerebrovascular diseases with nanozymes are discussed, mainly including cardiovascular diseases, ischemia reperfusion injury, and neurological disorders. Finally, the challenges and outlooks for the application of nanozymes are also presented. This review will provide some instructive perspectives on nanozymes and promote the development of enzyme‐mimicking strategies in cardio‐ and cerebrovascular disease therapy.

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Catalytic Nanoparticles in Biomedical Applications: Exploiting Advanced Nanozymes for Therapeutics and Diagnostics

Manoharan,

Wang,

Chen

et al. 2024

Adv Healthcare Materials

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Catalytic nanoparticles (CNPs) as heterogeneous catalyst reveals superior activity due to their physio‐chemical features, such as high surface‐to‐volume ratio and unique optical, electric, and magnetic properties. The CNPs, based on their physio‐chemical nature, can either increase the reactive oxygen species (ROS) level for tumor and antibacterial therapy or eliminate the ROS for cytoprotection, anti‐inflammation, and anti‐aging. In addition, the catalytic activity of nanozymes could specifically trigger a specific reaction accompanied by the optical feature change, presenting the feasibility of biosensor and bioimaging applications. Undoubtedly, CNPs play a pivotal role in pushing the evolution of technologies in medical and clinical fields, and advanced strategies and nanomaterials rely on the input of chemical experts to develop. Herein, we present a systematic and comprehensive review of the challenges and recent development of catalytic NPs for biomedical applications from the viewpoint of advanced nanomaterial with unique catalytic activity and additional functions. Furthermore, we critically discuss the biosafety issue of applying biodegradable and non‐biodegradable nanozymes and future perspectives to guide a promising direction in developing span‐new nanozymes and more intelligent strategies for overcoming the current clinical limitations.This article is protected by copyright. All rights reserved

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A GPx-mimetic copper vanadate nanozyme mediates the release of nitric oxide fromS-nitrosothiols

Abstract: Although reactive oxygen and nitrogen species (ROS/RNS) such as hydrogen peroxide (H2O2), nitric oxide (NO), hydroxyl radical (OH.), superoxide (O2-) etc. play crucial roles in redox biology and cellular signaling,...

Cited by 10 publications

References 68 publications

Glutathione peroxidase-like nanozymes: mechanism, classification, and bioapplication

Glutathione peroxidase-like nanozymes: mechanism, classification, and bioapplication

Nanozyme‐Enabled Treatment of Cardio‐ and Cerebrovascular Diseases

Catalytic Nanoparticles in Biomedical Applications: Exploiting Advanced Nanozymes for Therapeutics and Diagnostics

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