A graphene hybrid supramolecular hydrogel with high stretchability, self-healable and photothermally responsive properties for wound healing

Zhang, Haifeng; Zheng, Shiya; Chen, Canwen; Zhang, Dagan

doi:10.1039/d0ra09106e

Cited by 24 publications

(17 citation statements)

References 37 publications

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“…Hydrogels, as a 3D porous material, can keep a moist microenvironment, absorb inflammation exudate, and provide a physical barrier to prevent bacteria from entering the wound [ 11 , 12 ]. Other features of hydrogels include their excellent biocompatibility, adjustable degradation properties, and proper mechanical properties [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

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Photothermal treatment (PTT) is a promising strategy to deal with multidrug-resistant bacteria infection and promote tissue regeneration. Previous studies demonstrated that hyperthermia can effectively inhibit the growth of bacteria, whereas mild heat can promote cell proliferation, further accelerating wound healing and bone regeneration. Especially, hydrogels with photothermal properties could achieve remotely controlled drug release. In this review, we introduce a photothermal agent hybrid in hydrogels for a photothermal effect. We also summarize the potential mechanisms of photothermal hydrogels regarding antibacterial action, angiogenesis, and osteogenesis. Furthermore, recent developments in photothermal hydrogels in wound healing and bone regeneration applications are introduced. Finally, future application of photothermal hydrogels is discussed. Hydrogels with photothermal effects provide a new direction for wound healing and bone regeneration, and this review will give a reference for the tissue engineering.

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Section: Introductionmentioning

confidence: 99%

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

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“…The D band is an indication of structural defects or disorder of graphitic domains [ 29 ]. The ID/IG ratio is decreased, which denotes that the materials have a degree of disorder due to the introduction of SF in hydrogel [ 7 , 44 , 45 ]. As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…On post-treatment day 12, the wound site of GF/SF and CF@GF/SF hydrogel samples was significantly healed and covered the injured area compared to the control sample. These results showed that the antibacterial hydrogel could provide a suitable scaffold for cell attachment, proliferation, and wounds inhibition from infection can potentially improve the wound healing process [ 7 ]. The superior healing properties of hydrogel might be attributed to graphene and the sustained release of CF.…”

Section: Resultsmentioning

confidence: 99%

“…Various forms of silk fibroin have been used for wound dressing applications, including films, fiber, hydrogel, and sponges [ 18 ]. According to the characteristic structure of SF-based hydrogel with some unique properties such as adhesiveness and anti-oxidant to facilitate self-healing [ 7 , 19 ], the connection with antibiotics is an initial stage of research for improving wound healing [ 20 ]. Antibiotics are generally used to prevent bacterial infection and biofilm formation on skin wounds.…”

Section: Introductionmentioning

confidence: 99%

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Facile design and development of nano-clustery graphene-based macromolecular protein hydrogel loaded with ciprofloxacin to antibacterial improvement for the treatment of burn wound injury

Zhu

Chen

2021

Polym. Bull.

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Graphic abstract Nowadays, awareness about the burn wound is often considered difficult due to bacterial and other organism infections. The facile and eco-friendly preparations of antibiotic-loaded hydrogel-based bio-composites have great attention in the field of wound dressing for burn wound therapy and nursing care. In the present investigation, we have developed ciprofloxacin (CF)-encapsulated graphene-silk fibroin macromolecular hydrogel dressings material with unique chemical and physical properties to achieve the desirable antibacterial efficacy and healing activity. The antibacterial activity of prepared hydrogel was evaluated against bacterial pathogens treated with different concentrations of CF, which have been provided improved antibacterial activity on burn wound infection. In vitro , cytocompatibility evaluations were performed to imply the suitability of hydrogel on fibroblast cells, which has been dramatically related to in vivo wound healing. Furthermore, an in vivo wound healing analysis was carried out using a rat to observe the capability of the CF-incorporated GH/SF hydrogel matrix. Thus, this investigation widely demonstrates the healing ability of prepared hydrogel matrix and could be a significant landmark in the research on burn wound healing applications.

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“…In a recent investigation by Zhang et al N-acryloyl glycinamide (NAGA) based graphene hybrid supramolecular hydrogel (GS-hydrogel) was fabricated and investigated upon for its wound healing application. [41] The NIR-induced photothermal antimicrobial activity of graphene was reported for a better wound healing response of the hydrogel system.…”

Section: Figure 2 (A)mentioning

confidence: 99%

Graphene‐Based Nanomaterials for Biomedical, Catalytic, and Energy Applications

Basak

Gopinath

2021

ChemistrySelect

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Nanotechnology has provided us with unimaginable possibilities in addressing worldly challenges. Since its discovery in 2004, Graphene has been considered a "Holy Grail" of nanomaterials for its unprecedented applicability in different fields, including biomedical, energy harvest and storage, sensing applications. Throughout the world, tremendous waves of research have been going on to exploit graphene's unique thermal, mechanical, electrical, catalytic, and biological properties. Besides, efficient and tunable techniques of graphene's bulk manufacturing have been under thorough investigation. This article reviews various recent studies on large-scale graphene synthesis with tunable properties. Several different ways of graphene's use in various catalytic platforms are also reviewed. Furthermore, recent biomedical and energy (storage and harvest) applications of graphene, especially in microbial fuel cell technology, bio-sensing, antimicrobial applications, have been discussed in this article.

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A graphene hybrid supramolecular hydrogel with high stretchability, self-healable and photothermally responsive properties for wound healing

Abstract: The hydrogel demonstrated properties with high stretchability, self-healable and photothermal properties. Notably, photothermal therapy could be established due to its photothermal responsiveness, benefiting infected wound healing.

Cited by 24 publications

References 37 publications

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Facile design and development of nano-clustery graphene-based macromolecular protein hydrogel loaded with ciprofloxacin to antibacterial improvement for the treatment of burn wound injury

Graphene‐Based Nanomaterials for Biomedical, Catalytic, and Energy Applications

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