A Graphical Review on the Escalation of Fused Deposition Modeling (FDM) 3D Printing in the Pharmaceutical Field

Melocchi, Alice; Uboldi, Marco; Cerea, Matteo; Foppoli, Anastasia; Maroni, Alessandra; Moutaharrik, Saliha; Palugan, Luca; Zema, L.; Gazzaniga, A.

doi:10.1016/j.xphs.2020.07.011

Cited by 71 publications

(40 citation statements)

References 180 publications

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“…Additive manufacturing includes a wide range of manufacturing techniques based on the addition of layers of materials to form 3D objects. The mechanism used to add these layers can be based on hot-melt extrusion, photopolymerization or sintering among many others [ 23 , 24 , 25 , 26 , 27 ]. This family of technologies has been widely explored for the production of a wide range of drug delivery systems such as oral tablets, suppositories or implantable devices [ 16 , 22 , 23 , 24 , 25 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

“…The mechanism used to add these layers can be based on hot-melt extrusion, photopolymerization or sintering among many others [ 23 , 24 , 25 , 26 , 27 ]. This family of technologies has been widely explored for the production of a wide range of drug delivery systems such as oral tablets, suppositories or implantable devices [ 16 , 22 , 23 , 24 , 25 , 28 ]. However, the use of additive manufacturing for the development of drug-loaded devices for cardiovascular applications is relatively unexplored.…”

Section: Introductionmentioning

confidence: 99%

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Use of 3D Printing for the Development of Biodegradable Antiplatelet Materials for Cardiovascular Applications

et al. 2021

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Small-diameter synthetic vascular grafts are required for surgical bypass grafting when there is a lack of suitable autologous vessels due to different reasons, such as previous operations. Thrombosis is the main cause of failure of small-diameter synthetic vascular grafts when used for this revascularization technique. Therefore, the development of biodegradable vascular grafts capable of providing a localized and sustained antithrombotic drug release mark a major step forward in the fight against cardiovascular diseases, which are the leading cause of death globally. The present paper describes the use of an extrusion-based 3D printing technology for the production of biodegradable antiplatelet tubular grafts for cardiovascular applications. For this purpose, acetylsalicylic acid (ASA) was chosen as a model molecule due to its antiplatelet activity. Poly(caprolactone) and ASA were combined for the fabrication and characterization of ASA-loaded tubular grafts. Moreover, rifampicin (RIF) was added to the formulation containing the higher ASA loading, as a model molecule that can be used to prevent vascular prosthesis infections. The produced tubular grafts were fully characterized through multiple techniques and the last step was to evaluate their drug release, antiplatelet and antimicrobial activity and cytocompatibility. The results suggested that these materials were capable of providing a sustained ASA release for periods of up to 2 weeks. Tubular grafts containing 10% (w/w) of ASA showed lower platelet adhesion onto the surface than the blank and grafts containing 5% (w/w) of ASA. Moreover, tubular grafts scaffolds containing 1% (w/w) of RIF were capable of inhibiting the growth of Staphylococcus aureus. Finally, the evaluation of the cytocompatibility of the scaffold samples revealed that the incorporation of ASA or RIF into the composition did not compromise cell viability and proliferation at short incubation periods (24 h).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Use of 3D Printing for the Development of Biodegradable Antiplatelet Materials for Cardiovascular Applications

et al. 2021

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“…SMPs are generally characterized by a greater shape recovery capability with respect to alloys and they can turn out compatible with a variety of cost-effective manufacturing processes, which have recently started to be considered for their potential in the pharmaceutical field (e.g. hot melt extrusion, injection molding, 3D printing) [46][47][48][49][50][51][52][53][54][55]. For these reasons, they could be tailored to specific applications.…”

Section: Shape Memory Polymers (Smps)mentioning

confidence: 99%

Shape memory materials and 4D printing in pharmaceutics

Melocchi

Uboldi

Cerea

et al. 2021

Advanced Drug Delivery Reviews

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“…The potential and cost-effectiveness of 3D printing in the manufacturing of personalized and innovative drug products, especially when small batches are involved, were largely confirmed in the last five years [30][31][32][33][34]. Great attention is currently being paid to versatility-oriented design strategies and scale-down fabrication opportunities, which could better suit the rising needs of precision medicine [35][36][37][38].…”

Section: Introductionmentioning

confidence: 99%

The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of Precision Medicine: Feasibility by 3D Printing via Fused Deposition Modeling (FDM)

et al. 2021

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The pulsatile-release Chronotopic™ system was conceived of as a drug-containing core surrounded by a coat made of swellable/soluble hydrophilic polymers, the latter being able to provide a programmable lag phase prior to drug liberation. This system was also proposed in a colon-targeting configuration, entailing a gastroresistant film to prevent early interaction of the inner coat with gastric fluids and enabling the attainment of a lag phase matching the small intestinal transit time. Over the years, various multiple-step manufacturing processes have been tested for the fabrication of the Chronotopic™ system in both its configurations. This work focused on the evaluation of 3D printing by fused deposition modeling in view of its potential towards product personalization, on demand one-step manufacturing and efficient scale down of batches. The feasibility of each part of the Chronotopic™ system was independently investigated starting from in-house made filaments, characterizing the resulting specimens for physico-technological and performance characteristics. The printing parameters identified as suitable during the set-up phase were then used to fabricate prototypes either in a single step for the pulsatile configuration or following two different fabrication approaches for the colon-targeting one.

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A Graphical Review on the Escalation of Fused Deposition Modeling (FDM) 3D Printing in the Pharmaceutical Field

Cited by 71 publications

References 180 publications

Use of 3D Printing for the Development of Biodegradable Antiplatelet Materials for Cardiovascular Applications

Use of 3D Printing for the Development of Biodegradable Antiplatelet Materials for Cardiovascular Applications

Shape memory materials and 4D printing in pharmaceutics

The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of Precision Medicine: Feasibility by 3D Printing via Fused Deposition Modeling (FDM)

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