This study aims at investigating the multiple and complex relationships between transport and tourism by various methods. In this paper, spatial interaction model and the shift-share analysis are used in different approaches. Factors of the relationship between the transport distance and tourism intensity will be detected and the connections between the accessibility of European regions and their tourism will be analysed. One of the major questions of our study is if there is any relationship between transport and tourism at European regional level (NUTS2); and if so, is there any kind of regularity in the relationship, as Bull (1994) states in his study. Finally, we examined whether there are any differences in this relationship at the level of the European regions.