A great diversity of Amerindian mitochondrial DNA ancestry is present in the Mexican mestizo population

Guardado-Estrada, Mariano; Juárez-Torres, Eligia; Medina-Martínez, Ingrid; Wegier, Ana; Macías, Antonio Gutiérrez; Gómez, G. Esparza; Cruz-Talonia, Fernando; Román-Bassaure, Edgar; Piñero, Daniel; Kofman‐Alfaro, Susana; Berumen, Jaime

doi:10.1038/jhg.2009.98

Cited by 38 publications

(36 citation statements)

References 49 publications

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“…In addition, we found one individual from the Tarahumara group with haplogroup X, which is common in some natives from North America, especially Alaska [8]–[9]. Table 1 also describes frequencies of mtDNA haplogroups in Mexican and other groups reported previously and the previous data are in accord with ours, and emphasizes that Mestizo, Caucasian and Asian groups tend to differ in these mtDNA markers [10], [11], [12], [13].…”

Section: Resultssupporting

confidence: 87%

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Helicobacter pylori Genotyping from American Indigenous Groups Shows Novel Amerindian vacA and cagA Alleles and Asian, African and European Admixture

et al. 2011

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It is valuable to extend genotyping studies of Helicobacter pylori to strains from indigenous communities across the world to better define adaption, evolution, and associated diseases. We aimed to genetically characterize both human individuals and their infecting H. pylori from indigenous communities of Mexico, and to compare them with those from other human groups. We studied individuals from three indigenous groups, Tarahumaras from the North, Huichols from the West and Nahuas from the center of Mexico. Volunteers were sampled at their community site, DNA was isolated from white blood cells and mtDNA, Y-chromosome, and STR alleles were studied. H. pylori was cultured from gastric juice, and DNA extracted for genotyping of virulence and housekeeping genes. We found Amerindian mtDNA haplogroups (A, B, C, and D), Y-chromosome DYS19T, and Amerindian STRs alleles frequent in the three groups, confirming Amerindian ancestry in these Mexican groups. Concerning H.pylori cagA phylogenetic analyses, although most isolates were of the Western type, a new Amerindian cluster neither Western nor Asian, was formed by some indigenous Mexican, Colombian, Peruvian and Venezuelan isolates. Similarly, vacA phylogenetic analyses showed the existence of a novel Amerindian type in isolates from Alaska, Mexico and Colombia. With hspA strains from Mexico and other American groups clustered within the three major groups, Asian, African or European. Genotyping of housekeeping genes confirmed that Mexican strains formed a novel Asian-related Amerindian group together with strains from remote Amazon Aborigines. This study shows that Mexican indigenous people with Amerindian markers are colonized with H. pylori showing admixture of Asian, European and African strains in genes known to interact with the gastric mucosa. We present evidence of novel Amerindian cagA and vacA alleles in indigenous groups of North and South America.

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Section: Resultssupporting

confidence: 87%

“…aPeñaloza-Espinosa et al [11];bSánchez-Boiso et al [12];cGuardado-Estrada et al [13];d http://www.mitomap.org/bin/view.pl/MITOMAP/HaplogroupMarkers [14].…”

Section: Resultsunclassified

Helicobacter pylori Genotyping from American Indigenous Groups Shows Novel Amerindian vacA and cagA Alleles and Asian, African and European Admixture

et al. 2011

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“…This haplotype is widespread in Native American populations [21,22], and was also found in two individuals in our cosmopolitan MGNE control sample (data not shown).…”

Section: Resultssupporting

confidence: 71%

Recovering mitochondrial DNA lineages of extinct Amerindian nations in extant homopatric Brazilian populations

et al. 2010

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BackgroundBrazilian Amerindians have experienced a drastic population decrease in the past 500 years. Indeed, many native groups from eastern Brazil have vanished. However, their mitochondrial mtDNA haplotypes, still persist in Brazilians, at least 50 million of whom carry Amerindian mitochondrial lineages. Our objective was to test whether, by analyzing extant rural populations from regions anciently occupied by specific Amerindian groups, we could identify potentially authentic mitochondrial lineages, a strategy we have named 'homopatric targeting'.ResultsWe studied 173 individuals from Queixadinha, a small village located in a territory previously occupied by the now extinct Botocudo Amerindian nation. Pedigree analysis revealed 74 unrelated matrilineages, which were screened for Amerindian mtDNA lineages by restriction fragment length polymorphism. A cosmopolitan control group was composed of 100 individuals from surrounding cities. All Amerindian lineages identified had their hypervariable segment HVSI sequenced, yielding 13 Amerindian haplotypes in Queixadinha, nine of which were not present in available databanks or in the literature. Among these haplotypes, there was a significant excess of haplogroup C (70%) and absence of haplogroup A lineages, which were the most common in the control group. The novelty of the haplotypes and the excess of the C haplogroup suggested that we might indeed have identified Botocudo lineages. To validate our strategy, we studied teeth extracted from 14 ancient skulls of Botocudo Amerindians from the collection of the National Museum of Rio de Janeiro. We recovered mtDNA sequences from all the teeth, identifying only six different haplotypes (a low haplotypic diversity of 0.8352 ± 0.0617), one of which was present among the lineages observed in the extant individuals studied.ConclusionsThese findings validate the technique of homopatric targeting as a useful new strategy to study the peopling and colonization of the New World, especially when direct analysis of genetic material is not possible.

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“…1As indicated, reports including uniparental markers only (for instance, Rangel-Villalobos et al , 2008; Guardado-Estrada et al , 2009; Salazar-Flores et al , 2010; and Martinez-Cortés et al , 2009) were not included.21. Chowdhry et al (2006), Mexican recruited in the San Francisco Bay Area, USA; 2.…”

Section: Tablementioning

confidence: 99%

Interethnic admixture and the evolution of Latin American populations

2014

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A general introduction to the origins and history of Latin American populations is followed by a systematic review of the data from molecular autosomal assessments of the ethnic/continental (European, African, Amerindian) ancestries for 24 Latin American countries or territories. The data surveyed are of varying quality but provide a general picture of the present constitution of these populations. A brief discussion about the applications of these results (admixture mapping) is also provided. Latin American populations can be viewed as natural experiments for the investigation of unique anthropological and epidemiological issues.

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A great diversity of Amerindian mitochondrial DNA ancestry is present in the Mexican mestizo population

Cited by 38 publications

References 49 publications

Helicobacter pylori Genotyping from American Indigenous Groups Shows Novel Amerindian vacA and cagA Alleles and Asian, African and European Admixture

Helicobacter pylori Genotyping from American Indigenous Groups Shows Novel Amerindian vacA and cagA Alleles and Asian, African and European Admixture

Recovering mitochondrial DNA lineages of extinct Amerindian nations in extant homopatric Brazilian populations

Interethnic admixture and the evolution of Latin American populations

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