2021
DOI: 10.1134/s1023193520120137
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A Green Approach for Electrochemical Thiocyanation of Nitrogen Heterocycles with KSCN at Platinum Electrode

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Cited by 4 publications
(2 citation statements)
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“…3,4 Base pairs of DNA and RNA are composed of N-heterocycles (i.e., purines, pyrimidines). 5,6 Additionally, the electron-rich nitrogen heterocycles may easily create a variety of weak interactions like hydrogen bonding, p-stacking interactions and van der Waals forces and because of their increased solubility, they can interact with a wide range of enzymes and proteins in biologically active compounds with strong potential. 7,8 The pharmaceutical industry relies heavily on the utilization of the morpholine moiety as a building unit because it has been utilized in anti-inflammatory medicines, used to treat diseases such as asthma and migraines.…”
Section: Introductionmentioning
confidence: 99%
“…3,4 Base pairs of DNA and RNA are composed of N-heterocycles (i.e., purines, pyrimidines). 5,6 Additionally, the electron-rich nitrogen heterocycles may easily create a variety of weak interactions like hydrogen bonding, p-stacking interactions and van der Waals forces and because of their increased solubility, they can interact with a wide range of enzymes and proteins in biologically active compounds with strong potential. 7,8 The pharmaceutical industry relies heavily on the utilization of the morpholine moiety as a building unit because it has been utilized in anti-inflammatory medicines, used to treat diseases such as asthma and migraines.…”
Section: Introductionmentioning
confidence: 99%
“…Subjecting 1,1-diphenyl ethylene to 1a under the standard conditions gave the 1,2-dithiocyanation product 5b [(1,2-dithiocyanatoethane-1,1-diyl)dibenzene], which could be isolated and characterized by 1 H NMR and ESI-QTOF-HRMS studies, suggesting that the in situ generated thiocyanate radical (˙SCN) or thiocyanogen (SCN) 2 from ammonium thiocyanate was the common intermediate during the reaction (Scheme 2, iii). 17 c ,27 To understand the role of water in hydrogenation (C3N4), a deuterium-labeling experiment was performed (Scheme 2, iv). When the electrolysis of 1a was conducted in a CH 3 CN/D 2 O (4.8: 0.2) mixed solvent under the standard conditions, 3a- D (>95% D incorporation) bearing a deuterium atom at the C3-center was isolated.…”
Section: Resultsmentioning
confidence: 99%