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An atom economical, selective, and convenient one-pot protocol for the synthesis of the medicinally privileged novel chromeno [2,3-d] pyrimidine scaffold, viz, multicomponent reaction of barbituric acid derivatives, 1,3 cyclic diketone, and various aldehydes in the presence of tetra n-butyl ammonium iodide (TBAI) as an electrolyte in water media under room temperature, is reported.This ecologically sound novel concept offers environmentally benign synthetic route, short reaction times, and easy workup procedure with excellent yield (88% to 90%) and is also beneficial for diversity-oriented large-scale processes. The synthesized products were characterized by IR, MS, NMR, and CHN analysis.

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