A Greener and Facile Synthesis of Imidazole and Dihydropyrimidine Derivatives under Solvent‐Free Condition Using Nature‐Derived Catalyst

Tamuli, Kashyap J.; Dutta, Deepjyoti; Nath, Somsubhra

doi:10.1002/slct.201701487

Cited by 24 publications

(8 citation statements)

References 33 publications

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“…[114] The watery extract of pomelo (WEP) can also be an inexpensive and eco-friendly catalyst as shown by Bordoloi and co-workers in the metal-free production of dihydropyrimidine and imidazole derivatives (Scheme 24 and 25). [115] Kale and co-workers developed a green aerobic catalytic route for the Dakin oxidation reaction using fruit extracts (Scheme 26) [116] deploying aqueous extract of banana (AEB) as a natural catalyst; in a flexible, and economical manner with minimal environmental impact. Dakin oxidation reaction can also be accomplished using mango peel and potato peel extract (ultrasonic extraction), with even better results.…”

Section: P E R S O N a L A C C O U N T T H E C H E M I C A L R E C O R Dmentioning

confidence: 99%

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Valorisation of Fruits, their Juices and Residues into Valuable (Nano)materials for Applications in Chemical Catalysis and Environment

Nasrollahzadeh

Shafiei

Nezafat

et al. 2020

The Chemical Record

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One of the most abundant wastes from all around the world is nutrient resources. Among them, fruits, their extracts, and residues comprise a major portion, which contain many valuable components that get lost during disposal or become burden on the shrinking landfills. These concerns are addressed by seeking sustainable processing methods that would have a minimal environmental impact. The crops contain renewable chemicals which are useful for catalysis, wastewater treatment, or preparation of nanomaterials; there has been an upsurge for the industrial applications of (nano)materials as their environmental and catalytic appliances is a fascinating subject to design cheaper and safer catalytic systems. Due to the excellent chemical properties of the fruit extracts, they have garnered attention as cost-effective catalysts and support materials. This review focuses on the preparation of (nano)materials and their catalytic and environmental applications and highlights the potential appliances and industrial benefits derived from these low-cost renewable and sustainable greener sources thus essentially converting waste into wealth.

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Section: P E R S O N a L A C C O U N T T H E C H E M I C A L R E C O R Dmentioning

confidence: 99%

“…The watery extract of pomelo (WEP) can also be an inexpensive and eco‐friendly catalyst as shown by Bordoloi and co‐workers in the metal‐free production of dihydropyrimidine and imidazole derivatives (Scheme 24 and 25). [115] …”

Section: Application Of Fruits‐derived (Nano)materials In Catalysismentioning

confidence: 99%

Valorisation of Fruits, their Juices and Residues into Valuable (Nano)materials for Applications in Chemical Catalysis and Environment

Nasrollahzadeh

Shafiei

Nezafat

et al. 2020

The Chemical Record

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“…[ 23 ] Although these existing processes can afford easy access to quinoxaline derivatives, but the improvement of exceptionally eco‐friendly and greener organic synthetic artery is still desirable. Due to our interest in exploring the metal‐free, environment friendly synthetic protocols to construct some organic scaffolds or building blocks, [ 24 ] here we report a synthetic pathway for preparation of quinoxaline adducts in water using biodegradable itaconic acid as an acid promoter at room temperature. Itaconic acid is an important precursor in the polymer industry for the production of butadiene or synthetic rubber, renewable resource‐based resins and polyesters, lubricating oil additives, emulsion paints, super absorbents, etc.…”

Section: Introductionmentioning

confidence: 99%

In water organic synthesis: Introducing itaconic acid as a recyclable acidic promoter for efficient and scalable synthesis of quinoxaline derivatives at room temperature

Tamuli

Nath

Bordoloi

2021

Journal of Heterocyclic Chem

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Substituted quinoxaline derivatives are traditionally synthesized by co‐condensation of various starting materials. Herein, we describe a novel environmentally benign in water synthetic route for the synthesis of structurally and electronically diverse ninety quinoxalines with readily available substituted o‐phenylenediamine and 1,2‐diketones using cheap and biodegradable itaconic acid as a mild acid promotor in 1 hours. The reaction is performed at room temperature, which proceeds through cyclo‐condensation reaction followed by obtaining the aforesaid nitrogen‐containing heterocyclic adducts without performing the column chromatography up to 96% total yields. The simplicity, high efficiency, and reusable of the catalyst merits this reaction condition as “green synthesis” which enables it to be useful in synthetic transformations upto gram scale level.

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“…The major drawbacks of this procedure are lower yields and longer reaction time [4]. Therefore, we need to perform a very mild, simple, cost-effective, commercially beneficial and eco-friendly procedure for synthesis of dihydropyrimidinone derivatives for the academia and pharmaceutical industries [5]. Recently an efficient and facile green method has been developed for synthesizing substituted dihydropyrimidinones via Biginelli reaction at room temperature in presence of fruit juices viz amla, orange and lime juice [6].…”

Section: Introductionmentioning

confidence: 99%

One-pot three component synthesis of substituted dihydropyrimidinones using fruit juices as biocatalyst and their biological studies

et al. 2020

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New and facile one-pot three component approach for the synthesis of substituted dihydropyrimidinones derivatives (4a-4h) from reaction of equimolar substituted aldehydes (1a-1h), methyl acetoacetate (2a) and urea (3a) in presence of nature derived catalyst viz. Cocos nucifera L. juice, Solanum lycopersicum L. juice and Citrus limetta juice, commonly known as coconut juice, tomato juice and musambi juice respectively, at room temperature has been carried out. All synthesized compounds were evaluated for in vitro herbicidal activity against Raphanus sativus L. (Radish seeds). The compounds (4a-4h) were also screened for their antifungal activity against Rhizoctonia solani and Colletotrichum gloeosporioides by poisoned food techniques method. Antibacterial activity was also studied against Erwinia cartovora and Xanthomonas citri by inhibition zone method. From activity data, it was found that compounds 4g and 4d were most active against Raphanus sativus L. (root) and Raphanus sativus L. (shoot) respectively. Compounds 4f and 4c was found most active against Rhizoctonia solani and Colletotrichum gloeosporioides fungus respectively at highest concentration. Compound 4g has shown maximum inhibition zone i.e. 1.00-5.50 mm against Erwinia cartovora at 2000 μg/mL concentration. Maximum Xanthomonas citrii growth was inhibited by compounds 4f showing inhibition zone 4.00-12.00 mm at highest concentration. Short reaction time, high yields, mild reaction condition and simple work-up are some merits of present methodology.

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A Greener and Facile Synthesis of Imidazole and Dihydropyrimidine Derivatives under Solvent‐Free Condition Using Nature‐Derived Catalyst

Cited by 24 publications

References 33 publications

Valorisation of Fruits, their Juices and Residues into Valuable (Nano)materials for Applications in Chemical Catalysis and Environment

Valorisation of Fruits, their Juices and Residues into Valuable (Nano)materials for Applications in Chemical Catalysis and Environment

In water organic synthesis: Introducing itaconic acid as a recyclable acidic promoter for efficient and scalable synthesis of quinoxaline derivatives at room temperature

One-pot three component synthesis of substituted dihydropyrimidinones using fruit juices as biocatalyst and their biological studies

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