A guide to biological skin substitutes

Jones, Isabel; Currie, Lachlan; Martin, Robert H.

doi:10.1054/bjps.2002.3800

Cited by 395 publications

(273 citation statements)

References 79 publications

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“…31 One of the major goals of burn therapy is to quickly accomplish effective wound closure so as to increase the rate of healing and to provide immediate pain relief. [32][33][34] In addition, proper wound management must prohibit the wound from becoming infected and dehydrated. 35,36 Despite the fact that many different biological and synthetic wound dressings have already been developed, the search for an ideal wound dressing is still in progress.…”

Section: Microbial Cellulose As a Wound-healing Systemmentioning

confidence: 99%

“…Clinical evaluations of these skin substitutes are reported in several papers; however, the costs involved in their preparation are still very high. 62 Table 2 includes some of the commercially available skin treatments which are used in cases of severe burns or chronic wounds and compares them to microbial cellulose which, besides XCell products, is still in the clinical evaluation process. Most of the commercially available skin substitutes use collagen as a scaffold material.…”

Section: Integrated Microbial Cellulose: In Vivo Tissue-engineering Amentioning

confidence: 99%

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The Future Prospects of Microbial Cellulose in Biomedical Applications

et al. 2006

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Microbial cellulose has proven to be a remarkably versatile biomaterial and can be used in wide variety of applied scientific endeavors, such as paper products, electronics, acoustics, and biomedical devices. In fact, biomedical devices recently have gained a significant amount of attention because of an increased interest in tissue-engineered products for both wound care and the regeneration of damaged or diseased organs. Due to its unique nanostructure and properties, microbial cellulose is a natural candidate for numerous medical and tissue-engineered applications. For example, a microbial cellulose membrane has been successfully used as a wound-healing device for severely damaged skin and as a small-diameter blood vessel replacement. The nonwoven ribbons of microbial cellulose microfibrils closely resemble the structure of native extracellullar matrices, suggesting that it could function as a scaffold for the production of many tissue-engineered constructs. In addition, microbial cellulose membranes, having a unique nanostructure, could have many other uses in wound healing and regenerative medicine, such as guided tissue regeneration (GTR), periodontal treatments, or as a replacement for dura mater (a membrane that surrounds brain tissue). In effect, microbial cellulose could function as a scaffold material for the regeneration of a wide variety of tissues, showing that it could eventually become an excellent platform technology for medicine. If microbial cellulose can be successfully mass produced, it will eventually become a vital biomaterial and will be used in the creation of a wide variety of medical devices and consumer products.

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Section: Microbial Cellulose As a Wound-healing Systemmentioning

confidence: 99%

Section: Integrated Microbial Cellulose: In Vivo Tissue-engineering Amentioning

confidence: 99%

The Future Prospects of Microbial Cellulose in Biomedical Applications

et al. 2006

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“…Paucity of available autograft in major burns necessitates wide mesh grafting which can result in excessive granulation within the interstices and delayed wound healing leading to increased scar formation. Application of a dermal substitute underneath the autologous skin is a possibility to improve the wound healing process (van Zuijlen et al 2002, Jones et al 2002.…”

Section: Introductionmentioning

confidence: 99%

Development of a dermal matrix from glycerol preserved allogeneic skin

et al. 2008

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Dermal substitutes can be used to improve the wound healing of deep burns when placed underneath expanded, thin autologous skin grafts. Such dermal matrix material can be derived from xenogeneic or human tissue. Antigenic structures, such as cells and hairs must be removed to avoid adverse inflammatory response after implantation. In this study, a cost-effective method using low concentrations of NaOH for the de-cellularization of human donor skin preserved in 85% glycerol is described. The donor skin was incubated into NaOH for different time periods; 2, 4, 6 or 8 weeks. These dermal matrix prototypes were analyzed using standard histology techniques. Functional tests were performed in a rat subcutaneous implant model and in a porcine transplantation model; the prototypes were placed in full thickness excision wounds covered with autologous skin grafts.An incubation period of 6 weeks was most optimal, longer periods caused damage to the collagen fibers. Elastin fibers were well preserved. All prototypes showed intact biocompatibility in the rat model by the presence of ingrowing blood vessels and fibroblasts at 4 weeks after implantation. An inflammatory response was observed in the prototypes that were treated for only 2 or 4 weeks with NaOH. The prototypes treated with 6 or 8 weeks NaOH were capable to reduce wound contraction in the porcine model. In neo-dermis of these wounds, elastin fibers derived from the prototype could be observed at 8 weeks after operation, surrounded by more random orientated collagen fibers. Thus, using this effective low cost method, a dermal matrix can be obtained from human donor skin. Further clinical studies will be performed to test this material for dermal substitution in deep (burn) wounds.

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“…Elastin is functionally and spatially disorganized in scar tissue [28,29]. Expression of both elastin and fibrillin-1 are reduced in scar tissue with a particularly prominent reduction in hypertrophic scars [15].…”

Section: Discussionmentioning

confidence: 99%