A gut feeling: diet-sensing mesenchymal cells regulate intestinal stem cell function

Messina-Pacheco, Julia; Gregorieff, Alex

doi:10.1038/s41422-022-00658-2

Cited by 1 publication

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some of the positive effects of CR and fasting may be related to the impact of diet on adult stem-cell function [120]. CR enhances intestinal stem cells (ISCs) and neighboring niche cell numbers and increases stem cells' self-renewal capacity in response to reduced mTOR signaling from Paneth cells [121].…”

Section: Calorie Restriction and Fastingmentioning

confidence: 99%

“…Similarly, fasting induces ISC self-renewal, mediated by peroxisome proliferator-activated receptor δ (PPARδ) triggered by the oxidation of free fatty acids released from adipose tissue. This depends on the nutrient-sensing capacity of the ISCs [120]. Further, Deng et al showed that fasting reduced leptin-receptor-positive (Lepr+) cell numbers and, thus, serum leptin levels.…”

Section: Calorie Restriction and Fastingmentioning

confidence: 99%

See 1 more Smart Citation

Synergistic Strategies for Gastrointestinal Cancer Care: Unveiling the Benefits of Immunonutrition and Microbiota Modulation

Martinelli,

Lamminpää,

Dübüş

et al. 2023

Nutrients

View full text Add to dashboard Cite

Gastrointestinal (GI) cancers are a group of highly prevalent malignant tumors affecting the gastrointestinal tract. Globally, one in four cancer cases and one in three cancer deaths are estimated to be GI cancers. They can alter digestive and absorption functions, leading to severe malnutrition which may worsen the prognosis of the patients. Therefore, nutritional intervention and monitoring play a fundamental role in managing metabolic alterations and cancer symptoms, as well as minimizing side effects and increasing the effectiveness of chemotherapy. In this scenario, the use of immunonutrients that are able to modulate the immune system and the modification/regulation of the gut microbiota composition have gained attention as a possible strategy to improve the conditions of these patients. The complex interaction between nutrients and microbiota might contribute to maintaining the homeostasis of each individual’s immune system; therefore, concurrent use of specific nutrients in combination with traditional cancer treatments may synergistically improve the overall care of GI cancer patients. This work aims to review and discuss the role of immunonutrition and microbiota modulation in improving nutritional status, postoperative recovery, and response to therapies in patients with GI cancer.

show abstract

Section: Calorie Restriction and Fastingmentioning

confidence: 99%

Section: Calorie Restriction and Fastingmentioning

confidence: 99%