Dengue is a viral disease transmitted by the Aedes aegypti mosquito and less commonly by Aedes albopictus. This infection is caused by the dengue virus (DENV), an RNA virus belongs to the genus Flavivirus in the family Flaviviridae, which has four serotypes DENV1, DENV2, DENV3, and DENV4. In 1943, DENV1 was primarily detected in Japan and French Polynesia followed by reports in Hawaii in 1944 and 1945. DENV2 was initially detected in 1944 in the Philippines, Papua New Guinea, and in Indonesia in 1954 and 1956. DENV3 and DENV4 were first reported in Thailand and the Philippines in 1953. In Malaysia, a new 5th serotype (DENV-5) was first discovered in 2007. 1 After 1950 dengue epidemics became more common in many parts of South Asia, including Pakistan, India, SriLanka, and Bangladesh. Now, it is a major public health concern in these regions. Moreover, it is also found in tropical and subtropical regions including the Western Pacific, Africa, the Caribbean, and the Americas. It is most prevalent during the rainy season and typically occurs from June to October. 2 It can cause joint and muscle pain, high fever, and severe headaches, and it can be fatal in some cases. 3