A half-sandwich Ta^V dichlorido complex containing an O,N,O′-tridentate Schiff base ligand: synthesis, crystal structure and in vitro cytotoxicity

Abstract

A half-sandwich Ta V dichlorido complex containing an O,N,O 0 0 0 -tridentate Schiff base ligand: synthesis, crystal structure and in vitro cytotoxicity A new electroneutral half-sandwich tantalum(V) dichlorido complex containing pentamethylcyclopentadienyl (Cp*) and the double-deprotonated version of the Schiff base 2-ethoxy-6-, has been prepared and thoroughly characterized by elemental analysis, IR and NMR spectroscopy, mass spectrometry, density functional theory (DFT) calculations and single-crystal X-ray diffraction. The molecular structure revealed that the Ta V centre is coordinated by a 5 -Cp* ligand, two monodentate chlorido ligands and one O,N,O 0tridentate L 2À ligand. The crystal structure is stabilized by C-HÁ Á ÁC, C-HÁ Á ÁCl and CÁ Á ÁC intermolecular interactions. Moreover, the complex shows notable in vitro cytotoxicity against the A2780 human ovarian carcinoma cell line, with IC 50 = 14.4 mM, which is higher than that of the conventional platinumbased anticancer drug cisplatin (IC 50 = 20.1 mM). research papers Acta Cryst. (2019). C75, 248-254 Trávníček et al. A half-sandwich Ta V dichlorido complex 249 research papers 250 Trávníček et al. A half-sandwich Ta V dichlorido complex Acta Cryst. (2019). C75, 248-254 research papers Acta Cryst. (2019). C75, 248-254 Trávníček et al. A half-sandwich Ta V dichlorido complex 253

Enhancement of Cisplatin Cytotoxicity by Cu(II)–Mn(II) Schiff Base Tetradentate Complex in Human Oral Squamous Cell Carcinoma

“…Moreover, the combination of cisplatin with Schiff base demonstrated greater effects compared to sole treatment. Our data are in agreement with the data of Trávníček et al [ 32 ] who reported the cytotoxic effect of Schiff base ligand against ovarian carcinoma. Moreover, DNA cleavage activity and apoptosis of cancerous cells were previously reported as a mechanism Schiff base cytotoxic effect.…”