Enhancement of Cisplatin Cytotoxicity by Cu(II)–Mn(II) Schiff Base Tetradentate Complex in Human Oral Squamous Cell Carcinoma

Al-Serwi, Rasha Hamed; Othman, Gamal; Attia, Mohammed M.; Enan, Eman T.; El‐Sherbiny, Mohamed; Mahmoud, S. A.; Elsherbiny, Nehal M.

doi:10.3390/molecules25204688

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…This explains the down-regulation of anti-apoptotic gene activity in our result [ 29 ]. Apoptosis evaluated on cell line of oral squamous cell carcinoma claimed higher expression of BAX gene and p53 gene but the level of BCL2 anti-apoptosis gene was suppressed resembling our data [ 30 ].…”

Section: Discussionsupporting

confidence: 86%

Effect of glucose mediated oxidative stress on apoptotic gene expression in gingival mesenchymal stem cells

et al. 2021

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Background Diabetes is a common disease that causes gingival and periodontal problems. Stem cells isolated from dental sources are an emerging area of research with a potential to facilitate regenerative medicine. The stem cells retain the property of self-renewal and the ones isolated from dental sources are mainly multipotent mesenchymal stem cells that have the ability to self-renew as well as differentiation towards multiple lineages. Objectives We aimed to isolate and characterize gingival mesenchymal stem cells by pluripotency markers and investigated the effect of oxidative stress on growth kinetics and apoptotic gene expression of gingival cells exposed to glucose mediated oxidative stress. Methods In this study, we isolated gingival mesenchymal stem cells from gingiva. This was followed by morphologic analysis using inverted phase contrast microscopy and molecular profiling of these cells for the mRNA expression of specific genes. The isolated cells were cultured till passage 3 and then exposed to oxidative stress (high glucose concentration). We measured the apoptotic gene expression and compared their growth kinetics. Results The results showed that oxidative stress produced by glucose reduced growth kinetics and increased apoptotic gene expression in gingival mesenchymal stem cells. According to the genetic results, glucose activated TNF family to initiate apoptosis. Conclusion In conclusion, the present study demonstrated that high glucose obliterated cellular proliferation testified by evaluating growth kinetics and induced apoptotic gene expression in gingival mesenchymal stem cells. This initiated extrinsic apoptotic pathway mediated by TNF family. Therefore, in diabetes oral health condition is compromised and periodontal disease is common.

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Section: Discussionsupporting

confidence: 86%

Effect of glucose mediated oxidative stress on apoptotic gene expression in gingival mesenchymal stem cells

et al. 2021

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“…All the complexes were more active than the free Schiff base ligand and, in particular, the higher cytotoxic activity was exerted by Cu, Co and Zn complexes (IC 50 = 61.1, 90.4 and 61.3 µg/mL on MCF-7 cells, respectively; IC 50 = 52.7, 60.6 and 51.9 µg/mL on HCT-116, respectively). Al-Serwi et al (2020) [47] studied a Cu(II)-Mn(II) Schiff base tetradentate complex alone or in combination with cisplatin against squamous cell carcinoma cell line (SCC) in vitro, adopting the oral-derived gingival mesenchymal stem cells (GMSCs) as control. The IC 50 values, obtained via MTT assay, were 1 µg/mL for cisplatin and 250 µM for the Schiff base complex 10) on both the cell lines.…”

Section: Antiproliferative Activity Of Schiff Bases Complexed With Transition Metalsmentioning

confidence: 99%

A Review on the Advancements in the Field of Metal Complexes with Schiff Bases as Antiproliferative Agents

et al. 2021

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Metal complexes play an essential role in pharmaceutical sciences for their multiple and important activities. Schiff bases are versatile pharmacophores able to form chelating complexes with several metals in different oxidation states. Complexes with Schiff bases are widely described in the literature for their multiple actions and numerous advantages, such as low cost and easy synthesis. They show multiple biological activities, including antimicrobial, antioxidant, antimalarial, antinflammatory and antitumor. Schiff bases may also form complexes with lanthanides and actinides acting as catalysts (e.g., in various synthetic processes) and antitumor agents. This review intends to extend on our previous paper regarding Schiff bases as antitumorals, highlighting the importance, in the field of the anticancer agents, of these tools as ligands of metal complexes.

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“…Schiff base ligand features the ability to easily regulate the molecular and electronic structures of complexes, and tune their physicochemical properties [ 40 ]. Hence, Schiff base is a type of versatile ligand, which has been widely applied in various fields such as biological [ 41 , 42 , 43 , 44 , 45 ], analytical [ 46 ], and catalytic [ 47 , 48 , 49 , 50 , 51 ] fields. Recently, many Schiff base complexes have been utilized in electrocatalysis for CO 2 reduction or water oxidation.…”

Section: Introductionmentioning

confidence: 99%

Two Novel Schiff Base Manganese Complexes as Bifunctional Electrocatalysts for CO2 Reduction and Water Oxidation

Zhao

Jian

et al. 2023

Molecules

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One mononuclear Mn(III) complex [MnIIIL(H2O)(MeCN)](ClO4) (1) and one hetero-binuclear complex [(CuIILMnII(H2O)3)(CuIIL)2](ClO4)2·CH3OH (2) have been synthesized with the Schiff base ligand (H2L = N,N′-bis(3-methoxysalicylidene)-1,2-phenylenediamine). Single crystal X-ray structural analysis manifests that the Mn(III) ion in 1 has an octahedral coordination structure, whereas the Mn(II) ion in 2 possesses a trigonal bipyramidal configuration and the Cu(II) ion in 2 is four-coordinated with a square-planar geometry. Electrochimerical catalytic investigation demonstrates that the two complexes can electrochemically catalyze water oxidation and CO2 reduction simultaneously. The coordination environments of the Mn(III), Mn(II), and Cu(II) ions in 1 and 2 were provided by the Schiff base ligand (L) and labile solvent molecules. The coordinately unsaturated environment of the Cu(II) center in 2 can perfectly facilitate the catalytic performance of 2. Complexes 1 and 2 display that the over potentials for water oxidation are 728 mV and 216 mV, faradaic efficiencies (FEs) are 88% and 92%, respectively, as well as the turnover frequency (TOF) values for the catalytic reduction of CO2 to CO are 0.38 s−1 at −1.65 V and 15.97 s−1 at −1.60 V, respectively. Complex 2 shows much better catalytic performance for both water oxidation and CO2 reduction than that of complex 1, which could be owing to a structural reason which is attributed to the synergistic catalytic action of the neighboring Mn(III) and Cu(II) active sites in 2. Complexes 1 and 2 are the first two compounds coordinated with Schiff base ligand for both water oxidation and CO2 reduction. The finding in this work can offer significant inspiration for the future development of electrocatalysis in this area.

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Enhancement of Cisplatin Cytotoxicity by Cu(II)–Mn(II) Schiff Base Tetradentate Complex in Human Oral Squamous Cell Carcinoma

Cited by 4 publications

References 34 publications

Effect of glucose mediated oxidative stress on apoptotic gene expression in gingival mesenchymal stem cells

Effect of glucose mediated oxidative stress on apoptotic gene expression in gingival mesenchymal stem cells

A Review on the Advancements in the Field of Metal Complexes with Schiff Bases as Antiproliferative Agents

Two Novel Schiff Base Manganese Complexes as Bifunctional Electrocatalysts for CO2 Reduction and Water Oxidation

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