A headstrong case of folliculitis decalvans: Treatment options and evaluation with dermoscopy, reflectance confocal microscopy and optical coherence tomography

Peccerillo, Francesca; Mandel, Victor Desmond; Greco, Maurizio; Ciardo, Silvana; Pellacani, Giovanni

doi:10.1111/dth.14049

Cited by 3 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…OCT revealed a high‐intensity of vascular signal with deep plexus dilations focused in the perifollicular area, hair tufts and a follicular pustule. Following laser treatment, OCT could still detect follicular tufting, absence of pustules, reduced vascular signal and increased fibrosis 44 …”

Section: Resultsmentioning

confidence: 99%

“…The 39 studies included concerned the following 10 skin diseases: 14 studies of acne vulgaris, [7][8][9][10][11][12][13][14][15][16][17][18][19][20] nine studies of rosacea, [21][22][23][24][25][26][27][28] four studies of alopecia areata, [30][31][32][33] two studies of HS, 35,41 two studies of folliculitis, 34,42 two studies of folliculitis decalvans, 43,44 two studies of lichen planopilaris, 33,45 two studies of discoid lupus erythemasus, 33,46 one study of frontal fibrosing alopecia 47 and one including one patient with keratosis pilaris. 48 In total, 33 RCM studies, 12 OCT studies and 45 combined.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Following laser treatment, OCT could still detect follicular tufting, absence of pustules, reduced vascular signal and increased fibrosis. 44…”

Section: Various Types Of Folliculitismentioning

confidence: 99%

See 2 more Smart Citations

Confocal microscopy and optical coherence tomography of inflammatory skin diseases in hairs and pilosebaceous units: A systematic review

Al-Chaer

Bouazzi

Jemec

et al. 2023

Experimental Dermatology

View full text Add to dashboard Cite

Common skin disorders such as acne vulgaris, rosacea and folliculitis are bothersome prevalent inflammatory diseases of hair follicles that can easily be investigated bedside using optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) with micrometre resolution, opening a novel era for high‐resolution hair follicle diagnostics and quantitative treatment evaluation. EMBASE, PubMed and Web of Science were searched until 5 January 2023 to identify all studies imaging hair follicle characteristics by RCM and OCT for diagnosis and monitoring of treatment in hair follicle‐based skin disorders. This study followed PRISMA guidelines. After inclusion of articles, methodological quality was assessed using the QUADAS‐2 critical appraisal checklist. Thirty‐nine in vivo studies (33 RCM and 12 OCT studies) were included. The studies focused on acne vulgaris, rosacea, alopecia areata, hidradenitis suppurativa, folliculitis, folliculitis decalvans, lichen planopilaris, discoid lupus erythemasus, frontal fibrosing alopecia and keratosis pilaris. Inter‐ and perifollicular morphology including number of demodex mites, hyperkeratinization, inflammation and vascular morphology could be assessed by RCM and OCT in all included skin disorders. Methodological study quality was low, and interstudy outcome variability was high. Quality assessment showed high or unclear risk of bias in 36 studies. Both RCM and OCT visualize quantitative features as size, shape, content and abnormalities of hair follicles, and have potential to support clinical diagnosis and evaluate treatment effects. However, larger studies with better methodological quality are needed to implement RCM and OCT directly into clinical practice.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Confocal microscopy and optical coherence tomography of inflammatory skin diseases in hairs and pilosebaceous units: A systematic review

Al-Chaer

Bouazzi

Jemec

et al. 2023

Experimental Dermatology

View full text Add to dashboard Cite

show abstract

A case of severe folliculitis decalvans

Teplyuk,

Pinegin,

Varshavsky

et al. 2024

Russian Journal of Skin and Venereal Diseases

View full text Add to dashboard Cite

Folliculitis decalvans is a difficult to treat rare neutrophilic dermatosis that affects the scalp and leads to permanent scarring. The pathogenesis is currently not well understood; the influence of S.aureus antigens, a disorder of the skin microbiome, a defect in cell-mediated immunity, and an imbalance of pro-inflammatory cytokines are assumed. This disease is often associated with a marked decrease in quality of life, because in addition to significant external manifestations, the patient may experience pain, itching and burning in the areas of the rash. The main problem is that there is currently no effective therapy for this disease. Treatment options include systemic antibiotics, topical and intralesional corticosteroids, dapsone, isotretinoin, biologics, and photodynamic therapy. We present a brief overview of the main methods of therapy and a clinical case of a long course of severe folliculitis decalvans, refractory to the main methods of treatment.

show abstract