A healing promoting wound dressing with tailor-made antibacterial potency employing piezocatalytic processes in multi-functional nanocomposites

Abstract

Developing novel antibiotics-free antibacterial strategy is essential for minimizing bacterial resistance. Materials not only kill bacterial but also promote tissue healing are especially challenging to achieve. Inspired by chemical conversion...

A comprehensive review on the applications of carbon-based nanostructures in wound healing: from antibacterial aspects to cell growth stimulation

“…The produced ROS killed bacterial cells and the sterilizing rate for S. aureus and E. coli reached 84.11% and 94.85% after 10 min application, respectively. 191 Shei et al prepared a type of hydrogel by combining poly(ethylene glycol) (PEG), oligo (ethylene glycol) methacrylate and 2-(2-methoxy ethoxy) ethyl methacrylate derivatives, with heat storage capacity and thermal conductivity through a one-pot method for burn therapy. The hydrogel was composed of heat-responsive PEG derivatives and CNT-OH performed a function of rapid heat absorption, which further reduced thermal damage and promoted wound healing.…”

Ultrasound-triggered piezocatalytic composite hydrogels for promoting bacterial-infected wound healing

“…The reason for the phenomenon that US-triggered piezocatalytic therapy has a side-effect on bacteria but not fibroblasts cells is probably that the respiratory chain of mammalian cells regulating electron transfer and ROS generation is in the intracellular organ's mitochondria [ 52 ]. Therefore, mammalian cells are more resistant to external ROS disturbance than bacteria [ 53 ]. More importantly, a controlled amount of ROS was generated by adjusting the US power to ensure both good biocompatibility and satisfactory bactericidal performance ( Fig.…”

Sonopiezoelectric Nanomedicine and Materdicine

“…[11] Sonopiezoelectric nanomaterials play a pivotal role in a multitude of nanomedicine fields including, but not limited to, biosensing, [12] cancer therapy, [11] tissue regeneration, [13] drug delivery, [14] and antibacteria. [15] On the one hand, electrical stimulation is ubiquitous in most physiological processes of living organisms such as neurophysiological effect, [16,17] elevating intracellular calcium ion (Ca 2+ ) concentration, [18] promoting cell migration, osteogenesis, and chondrogenesis. [19] This prominent electrical stimulation can be generated via US-activated sonopiezoelectric biomaterials where US features high tissue penetration and achieves precise spatial/temporal noninvasive stimulation.…”