A helpful method for controlled synthesis of monodisperse gold nanoparticles through response surface modeling

Oliveira, Jairo Pinto de; Prado, Adilson Ribeiro; Keijok, Wanderson Juvencio; Ribeiro, Moisés R. N.; Pontes, Maria José; Nogueira, Breno Valentim; Guimarães, Marco César Cunegundes

doi:10.1016/j.arabjc.2017.04.003

Cited by 67 publications

(32 citation statements)

References 33 publications

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“…The peak around 400 nm corresponds to dipolar mode excitation of spherical silver nanoparticles, but there is no significant position shifting of LSPR due to their size increasing from a few nanometers to tens of nanometers [34]. The large full width at half maximum (FWHM) is attributable to large polydispersity which promotes wider absorbance bands [35]. Although the nanoparticles synthesized by laser ablation in the solution can form stable colloidal solution, the nanoparticles can form networks or small assemblies [36] due to the attractive van der Waal forces in the absence of capping agents.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Deposition of Ag Nanoparticles by Combining Laser Ablation and Electrophoretic Deposition Techniques

et al. 2019

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Silver nanostructured thin films have been fabricated on silicon substrate by combining simultaneously pulsed laser ablation in liquid (PLAL) and electrophoretic deposition (ED) techniques. The composition, topography, crystalline structure, surface topography, and optical properties of the obtained films have been studied by energy dispersive X-ray spectroscopy (EDS), high-resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD), and UV-visible spectrophotometry. The coatings were composed of Ag nanoparticles ranging from a few to hundred nm. The films exhibited homogenous morphology, uniform appearance, and a clear localized surface plasmon resonance (LSPR) around 400 nm.

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Section: Resultsmentioning

confidence: 99%

Synthesis and Deposition of Ag Nanoparticles by Combining Laser Ablation and Electrophoretic Deposition Techniques

et al. 2019

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“…Polydispersity produces wider absorbance bands and monodispersity produces narrower ones. A low FWHM value indicates monodispersity, while higher values indicate polydispersity of particles [21]. The instability of AuNPs is augmented by an increasingly widened spectrum with a high FWHM value.…”

Section: Discussionmentioning

confidence: 99%

Synthesis and Stability Test of Resveratrol-Conjugated Gold Nanoparticle With Polyvinyl Alcohol Stabilization

Sutriyo

Iswandana²,

Hafshari

2020

Int J App Pharm

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Objective: Gold nanoparticles (AuNPs) have been developed as a promising effective site-specific drug to increase drug efficacy and reduce potentialside effects. However, AuNPs are unstable because they easily aggregate. This study aims to produce stable resveratrol (RSV)-conjugated AuNPs usingpolyvinyl alcohol (PVA).Methods: AuNPs were synthesized using the Turkevich method, which involves the reduction of chloroauric acid with sodium citrate as a reductor.AuNPs were then modified with PVA as a stabilizing agent and conjugated with RSV as a drug model in the carrier system. The formed conjugates werecharacterized using ultraviolet–visible spectrophotometry, Fourier transform infrared spectroscopy, particle size analysis, and high-performanceliquid chromatography. Furthermore, stability tests were performed in various media (2% bovine serum albumin [BSA], 1% cysteine, phosphatebufferedsaline [PBS] pH 4, PBS pH 7.4, and 0.9% NaCl) for 28 days.Results: RSV–AuNPs–PVA had a particle size of 78.75 nm, with polydispersity index (PDI) of 0.356, zeta potential of −36.1 mV, and highest entrapmentefficiency of 78.1%±0.7. RSV–AuNPs without PVA stabilization had a particle size of 51.97 nm, with PDI of 0.694 and zeta potential of −24.6 mV. Theresults of the stability tests demonstrated that RSV–AuNPs–PVA was stable in 2% BSA, PBS pH 7.4, PBS pH 4, and NaCl 0.9% and were unstable in 1%cysteine. RSV–AuNPs without PVA were stable in 2% BSA and PBS pH 7.4 and unstable in 1% cysteine, PBS pH 4, and 0.9% NaCl.Conclusion: PVA can improve the physical stability of RSV-AuNPs conjugates.

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“…The absence of changes in the absorbance and wavelength of the UV-visible spectrum indicates that the AuNPs were stable [14]. A low FWHM indicates monodispersity while a high FWHM indicates polydispersity [19]; thus, the wider the FWHM is, the more unequal the sizes of the colloidal AuNPs, which may indicate that the AuNPs aggregated. The results are shown in Fig.…”

Section: Stability In Various Mediamentioning

confidence: 99%

Synthesis and Stability of Resveratrol-Conjugated Gold Nanoparticles Modified With Polyethylene Glycol

2020

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Objective: Gold nanoparticles (AuNPs) are highly useful for drug delivery, but their application is limited by their stability as they readily aggregate.This issue can be prevented by adding a stabilizing agent such as resveratrol (RSV), which is a polyphenol derived from plants, that is used to preventcancer. Therefore, we propose a novel method to prepare stable RSV-conjugated nanoparticles modified with polyethylene glycol (RSV-AuNP-PEG).Methods: In the first step, the Turkevich method was used to synthesize the AuNPs. Then, PEG was added as stabilizer agent and conjugated with RSV.The synthesized conjugates were characterized using ultraviolet-visible spectrophotometry, Fourier transform infrared spectroscopy, particle sizeanalysis, and high-performance liquid chromatography.Results: The obtained RSV-AuNP-PEG had a particle size of 83.93 nm with a polydispersity index (PDI) of 0.562 and formed a translucent purple-redfluid in solution. The zeta potential was −22.9 mV, and the highest entrapment efficiency was 75.86±0.66%. For comparison, the RSV-AuNP solutionwas purple and turbid, the particle size was 51.97 nm with a PDI of 0.694, and the zeta potential was −24.6 mV. The stability test results showed thatthe storage stability of RSV-AuNP-PEG was better than that of AuNP-RSV. Further, the RSV-AuNP-PEG was shown to be most stable in 2% bovine serumalbumin (BSA) while the AuNP-RSV was most stable in 2% BSA in phosphate-buffered saline pH 7.4.Conclusion: These results show that modification of RSV-conjugated AuNPs with PEG effectively prevents their aggregation in storage, but only incertain mediums.

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A helpful method for controlled synthesis of monodisperse gold nanoparticles through response surface modeling

Cited by 67 publications

References 33 publications

Synthesis and Deposition of Ag Nanoparticles by Combining Laser Ablation and Electrophoretic Deposition Techniques

Synthesis and Deposition of Ag Nanoparticles by Combining Laser Ablation and Electrophoretic Deposition Techniques

Synthesis and Stability Test of Resveratrol-Conjugated Gold Nanoparticle With Polyvinyl Alcohol Stabilization

Synthesis and Stability of Resveratrol-Conjugated Gold Nanoparticles Modified With Polyethylene Glycol

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