A hemispheric comparison of cognitive dysfunction and sleep quality impairment in Middle Cerebral Artery infarction

Wahid, Danyal; Rabbani, Hifza; Inam, Ayesha; Akhtar, Zubaa

doi:10.12669/pjms.36.3.1385

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…This study showed that the highest risk factor found between both groups was hypertension (>80% Study conducted based in Pakistan showed a higher rate of left hemisphere ischemic stroke patients than right. 16 Different from our study, most of the patients had strokes on their right hemispheres (47.2%). In a former study, it was found that left middle cerebral artery stroke patients may be more prone to greater degree of cognitive impairment than right MCA.…”

Section: Sample Descriptioncontrasting

confidence: 79%

Comparison of Cognitive Function Between First Ischemic Stroke and Recurrent Ischemic Stroke Patients

Rizkia¹,

Calista²,

Gunadharma³

et al. 2022

MNJ

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Background: Cognitive impairment is a common condition that may affect up to 50% of stroke patients. Post stroke cognitive impairment is associated with reduced quality of life, which may increase the number of dependency. Recurrent stroke may happen in approximately 25% patients and they have higher rates of cognitive impairment. Objective: The aim of this study is to examine the comparison of cognitive function between first ischemic stroke and recurrent ischemic stroke patients in Hasan Sadikin Hospital, Bandung. Methods: This study is a retrospective, cross-sectional study using the data recruited between the year 2012 - 2016 at the Department of Neurology at the Hasan Sadikin Hospital Bandung. The data collected in this study were demographic data, including age, level of education, and residence, and the clinical data as well. Cognitive function was assessed using Mini-Mental State Examination (MMSE). The comparison between the cognitive function between both groups were analyzed using the Mann-Whitney U test. Results: There were 428 subjects eligible for this study, with 207 subjects categorized as first ischemic stroke group and 221 subjects categorized as recurrent ischemic stroke group. There was a statistically significant difference in MMSE scores between the first ischemic stroke patients (24.90 ± 4.64) and recurrent ischemic stroke patients (22.85 ± 4.64 ) with a p value of 0.002. Conclusion: Recurrent ischemic stroke patients had lower MMSE scores than the first ischemic stroke patients. Clinicians should be more aware in detecting early cognitive impairment in stroke patients and in preventing the incidence of recurrent stroke.

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Section: Sample Descriptioncontrasting

confidence: 79%

Comparison of Cognitive Function Between First Ischemic Stroke and Recurrent Ischemic Stroke Patients

Rizkia¹,

Calista²,

Gunadharma³

et al. 2022

MNJ

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“…Depending on the occlusion time, varying levels of lesion severity can be obtained in this model, however, 1 h occlusion in the MCAO model produces reproducible infarction in the MCA territories, including the frontoparietal cortex and lateral caudoputamen, and mimics human stroke symptoms [ 44 , 45 ]. We specifically targeted the right MCA in this study since sleep disturbances are commonly observed in patients with right hemispheric infarcts [ 46 , 47 , 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

Ischemic Stroke Disrupts Sleep Homeostasis in Middle-Aged Mice

Sharma

Chischolm

Parikh

et al. 2022

Cells

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Sleep disturbances, including insomnia and excessive daytime sleepiness, are highly prevalent in patients with ischemic stroke (IS), which severely impacts recovery and rehabilitation efforts. However, how IS induces sleep disturbances is unclear. Three experiments were performed on middle-aged C57BL/6J mice, instrumented with sleep recording electrodes and/or subjected to 1 h of middle cerebral artery (MCAO; Stroke group) or sham (Sham group) occlusion to induce IS. After 48 h of reperfusion (a) experiment 1 verified sensorimotor deficit (using Garcia scale) and infarction (using TTC staining) in this mouse model; (b) experiment 2 examined the effects of IS on the quality (sleep latency and NREM delta power) and quantity (duration) of sleep; and (c) experiment 3 determined the effects of IS on sleep homeostasis using sleep deprivation (SD) and recovery sleep (RS) paradigm. Stroke mice display (a) a significant correlation between sensorimotor deficit and cerebral infarction; (b) insomnia-like symptoms (increased sleep latency, reduced NREM duration and delta power) during the light (inactive) period and daytime sleepiness-like symptoms during the dark (active) period mimicking sleep in IS patients; and (c) impairments in the markers of sleep pressure (during SD) and sleep dissipation (during RS). Our results suggest that IS disrupts sleep homeostasis to cause sleep disturbances.

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“…Previous studies have reported that patients with left hemisphere cerebral infarction have a worse prognosis [ 29 – 31 ]. In a cognitive study involving nine sub-tests [ 32 ], cognitive impairment and sleep quality impairment caused by middle cerebral artery stroke were observed in the left and right hemispheres, regardless of gender. In another previous study investigating motor observation and imagination ability of hemispheric stroke patients [ 33 ], patients with left subcortical lesions recruited more cortical regions when processing motor images and videos, suggesting that lesions in the dominant hemisphere had a greater impact on the motor system.…”

Section: Discussionmentioning

confidence: 99%

Changes of cerebral cortical structure and cognitive dysfunction in “healthy hemisphere” after stroke: a study about cortical complexity and sulcus patterns in bilateral ischemic adult moyamoya disease

Liu

Wei

et al. 2021

BMC Neurosci

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Background Moyamoya disease (MMD) is an uncommon cerebrovascular disease which leads to progressive stenosis and occlusion of the bilateral internal carotid artery and main intracerebral arteries. Concerns are always on how the hemisphere with infarction affects cognitive function, while little attention is paid to the role that the non-infarcted hemisphere plays. Therefore, we aimed to detect cortical indexes, especially cortical complexity in the left or right hemisphere separately in patients with MMD after stroke. Methods 28 patients with MMD (14 males, 14 females) and 14 healthy controls were included in this study. All participants underwent cognitive tests and magnetic resonance imaging (MRI) scan. The preprocessing of three-dimensional T1 weighted images were performed by standard surface-based morphometry. Surface-based morphometry statistical analysis was carried out with a threshold of False Discovery Rate (FDR) P < 0.05 and fractal dimension (FD) was used to provide a quantitative description of cerebral cortical complexity. Results Widespread cognitive dysfunctions were found in MMD patient with stroke. Extensive FD reduction in the left hemisphere with right-sided infarction, mainly in the superior temporal, inferior frontal, and insula, while the post central gyrus, superior parietal, and inferior parietal gyrus also showed a wide range of significant differences (FDR corrected P < 0.05). Meanwhile, FD changes in the right hemisphere with left-sided infarction are restricted to the precuneus and cingulate isthmus (FDR corrected P < 0.05). Conclusions Extensive cognitive impairment was reconfirmed in Moyamoya disease with stroke, while wild and asymmetrical decrease of cortical complexity is observed on both sides. These differences could be relative to unbalanced cognitive dysfunction, and may be the result of a long-term chronic ischemia and compensatory of the contralateral hemisphere to the infarction.

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A hemispheric comparison of cognitive dysfunction and sleep quality impairment in Middle Cerebral Artery infarction

Cited by 5 publications

References 21 publications

Comparison of Cognitive Function Between First Ischemic Stroke and Recurrent Ischemic Stroke Patients

Comparison of Cognitive Function Between First Ischemic Stroke and Recurrent Ischemic Stroke Patients

Ischemic Stroke Disrupts Sleep Homeostasis in Middle-Aged Mice

Changes of cerebral cortical structure and cognitive dysfunction in “healthy hemisphere” after stroke: a study about cortical complexity and sulcus patterns in bilateral ischemic adult moyamoya disease

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