A heteromultivalent host–guest sensor array for cell recognition and discrimination

Abstract

We present a supramolecular sensor array based on a series of heteromultivalent macrocyclic coassemblies using amphiphilic calixarenes and cyclodextrin as the building blocks for cell recognition. The corresponding cross-reactivity between...

Molecular Recognition with Macrocyclic Receptors for Application in Precision Medicine

“…(c) Canonical score plots of the two factors of the simplified fluorescence response patterns of four different cell lines (upper) and mixed cell lines (bottom). Adapted with permission from ref . Copyright 2022 Royal Society of Chemistry.…”

“…Using proteins as model analytes, these sensor arrays exhibited effective distinguishing capacities . Subsequently, a coassembly-based sensor array was applied in recognizing and distinguishing cells, and we successfully distinguished normal cell lines and different cancer cell lines . The sensor array could also be employed to study the cross-contaminated cells and distinguish cancer cells via semiquantitative analysis (Figure c).…”

“…4 Subsequently, a coassembly-based sensor array was applied in recognizing and distinguishing cells, and we successfully distinguished normal cell lines and different cancer cell lines. 42 The sensor array could also be employed to study the cross-contaminated cells and distinguish cancer cells via semiquantitative analysis (Figure 1c). In addition to the sensing of disease-related molecules, 43 differential sensing has broad applications in other fields, such as the evaluation of complex traditional Chinese medicines and the discrimination of adulterated honey.…”

Identification of Pancreatic Metastasis Cells and Cell Spheroids by the Organelle‐Targeting Sensor Array

“…[ 29 ] Recently, Hu et al reported a host–guest sensor array to identify normal cell lines, cancerous cell lines, and cross‐contaminated cells. [ 30 ] Liu et al reported a lipid droplet‐targeted sensor array for analyzing the lipid droplet state in different cell states. [ 31 ] Our previous work reported a mitochondrion‐targeted sensor array for the identification of various cells.…”

Mixed host co-assembled systems for broad-scope analyte sensing

“…The majority of reported multimacrocyclic host systems rely on non-specic amphiphilic aggregation to co-assemble different host classes, allowing for self-adaptable detection of larger peptide biotargets, 27 and the ability to differentiate model proteins, 28 and cell lines. 29 A recent report shows that macrocycles containing different integrated uorophores have improved discrimination power when they are combined in solution, forming an adaptive network of sensors. 30 Despite these advances, one consistent limitation of supramolecular host chemosensors is they tend to detect only a single class of analyte.…”