A highly integrated, wearable electrical impedance tomography (EIT) belt for neonatal thorax vital multiple sign monitoring is presented. The belt has sixteen active electrodes. Each has an application specific integrated circuit (ASIC) connected to an electrode. The ASIC contains a fully differential current driver, a high-performance instrumentation amplifier (IA), a digital controller and multiplexors. The belt features a new active electrode architecture that allows programmable flexible electrode current drive and voltage sense patterns under simple digital control. It provides intimate connections to the electrodes for the current drive and to the IA for direct differential voltage measurement providing superior common-mode rejection ratio. The ASIC was designed in a CMOS 0.35-µm high-voltage technology. The high specification EIT belt has an image frame rate of 122 fps, a wide operating bandwidth of 1 MHz and multifrequency operation. It measures impedance with 98% accuracy and has less than 0.5 Ω and 1 o variation across all possible channels. The image results confirmed the advantage of the new active electrode architecture and the benefit of wideband, multifrequency EIT operation. The system successfully captured high quality lung respiration EIT images, breathing cycle and heart rate. It can also provide boundary shape information using an array of MEMS sensors interfaced to the ASICs.