A high-accuracy measurement method of glucose concentration in interstitial fluid based on microdialysis

Abstract

A high-accuracy microdialysis method that can provide the reference values of glucose concentration in interstitial fluid for the accurate evaluation of non-invasive and minimally invasive continuous glucose monitoring is reported in this study. The parameters of the microdialysis process were firstly optimized by testing and analyzing three main factors that impact microdialysis recovery, including the perfusion rate, temperature, and glucose concentration in the area surrounding the microdialysis probe. The precision of the optimized microdialysis method was then determined in a simulation system that was designed and established in this study to simulate variations in continuous glucose concentration in the human body. Finally, the microdialysis method was tested for in vivo interstitial glucose concentration measurement.

Bioglass Activated Albumin Hydrogels for Wound Healing

“…[55] There are many methods and calculation models to test the RR as described in ref. [56]. In this study, an in vitro microdialysis recovery experiment was conducted in order to calculate the RR.…”

Enhanced Interstitial Fluid Extraction and Rapid Analysis via Vacuum Tube‐Integrated Microneedle Array Device

“…In this way, the ISF glucose of the live, healthy NZ rabbit after 12‐h fasting was obtained to be 6.0 mM (Figure S9 , Supporting Information), aligning with previous reports. [ 49 ] These results suggest that our device can be combined conveniently with specific commercial personal medical sensors that require only several µL‐level sample volumes, thereby realizing rapid analysis of skin ISF.…”