A high adhesion co‐assembly based on myclobutanil and tannic acid for sustainable plant disease management

Abstract

BackgroundPesticides are irreplaceable inputs for protecting crops from pests and improving crop yield and quality. Self‐assembly nanotechnology is a promising strategy by which to develop novel nano‐formulations for pesticides. Nano‐formulations improve the effective utilization of pesticides and reduce risks to the environment because of their eco‐friendly preparation, high drug loading, and desirable physicochemical properties. Here, to enhance the utilization efficiency of myclobutanil (MYC) and develop a novel nano‐formulation, carrier‐free co‐assembled nanoparticles (MT NPs) based on MYC and tannic acid (TA) were prepared by noncovalent molecular interactions using a green preparation process without any additives.ResultsThe results showed that the prepared spherical nanoparticles had good stability in neutral and acidic aqueous solutions, low surface tension (40.53 mN m−1), high rainfastness, and good maximum retention values on plant leaves. Release of active ingredients from MT NPs could be regulated by altering the molar ratio of subassemblies in the co‐assembly and the pH of the environment. Antifungal experiments demonstrated that MT NPs had better activities against Alternaria alternata and Fusarium graminearum [half‐maximal effective concentration (EC50) = 6.40 and 77.08 mg/L] compared with free MYC (EC50 = 11.46 and 124.82 mg/L), TA (EC50 = 251.19 and 503.81 mg/L), and an MYC + TA mixture (EC50 = 9.62 and 136.21 mg/L). These results suggested that MYC and TA incorporated in the co‐assembled nanoparticles had a synergistic antifungal activity. The results of a genotoxicity assessment indicated that MT NPs could reduce the genotoxicity of MYC to plant cells.ConclusionCo‐assembled MT NPs with synergistic antifungal activity have outstanding potential for the management of plant diseases. © 2023 Society of Chemical Industry.

Making the Complicated Simple: A Minimizing Carrier Strategy on Innovative Nanopesticides

“…It is evident that the variances in preparation strategy and material choices between NMC and NNC systems directly result in essential difference in loading capacity between the two systems. For nanopesticides, the superior loading capacity exhibited by NMC delivery systems can play a crucial role in reducing the dose administered, offering a potential strategy to mitigate the development of pesticide resistance and improve safety [ 40 ].…”

“…This study introduces innovative approaches for creating NMC systems incorporating botanical pesticides. Based on nanoprecipitation method, Li et al [ 40 ] regulated the solvent for precipitating myclobutanil, and during this precipitation process, tannic acid, possessing a noncovalent molecular structure, could interact with myclobutanil. The bound molecules persistently rotated and intertwined through noncovalent interactions, culminating in the formation of a spherical three-dimensional structure (Fig.…”

“…C Schematic illustration of 2,4-dichlorophenoxyacetic acid or picloraml and phytantriol or glyceryl monooleate forming NMC based on ester bond [54], copyright 2018, Elsevier. D Schematic illustration of myclobutanil and tannic acid forming NMC based on noncovalent interaction [40], copyright 2023, Wiley Online. E Schematic illustration of spinosad and sulfamic acid forming NMC based on noncovalent interaction [58], copyright 2021, Royal Society of Chemistry i) Some pesticide molecules with amino group can be bonded to small molecules, enabling the construction of prodrug conjugates [51].…”

Fabrication of Hollow Mesoporous Copper Sulfide Nanocapsules Loaded with Natural Photoactivated Pesticides for Sustainable Plant Disease Management

“…The rainfastness of the samples on the surface of the plant leaf was measured quantitatively by simulating the rainwashing method described in our previous work. 32 Briefly, 1.0 mL of an aqueous suspension of samples with an active ingredient concentration of 100 mg L −1 was evenly sprayed onto the cucumber and tomato leaves on a Petri dish with a tilt angle of 30°from the ground and dried naturally. Then, deionized water was sprayed on the leaves to simulate the rainwater.…”