2007
DOI: 10.4088/jcp.v68n0419
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A High-Density Whole-Genome Association Study Reveals That APOE Is the Major Susceptibility Gene for Sporadic Late-Onset Alzheimer's Disease

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Cited by 514 publications
(383 citation statements)
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“…[39][40][41][42][43][44][45] Altogether, we observed a statistically significant enrichment of genes associated with complex disease, …”
Section: Discussionmentioning
confidence: 70%
“…[39][40][41][42][43][44][45] Altogether, we observed a statistically significant enrichment of genes associated with complex disease, …”
Section: Discussionmentioning
confidence: 70%
“…When using family-based association tests however, we observed modest support for association with D19S245, located approximately 10 cM away from the APOE locus. In a recent paper, Coon et al [45] demonstrated that the APOE locus as a susceptibly locus for late onset AD was identified when they saturate the genome with over 300, 000 SNP markers.…”
Section: Discussionmentioning
confidence: 99%
“…LOAD is believed to be a disease with both genetic and environmental influences, and elucidating the role of genetic factors in the pathogenesis and development of LOAD has been a major focus of research for more than a decade. One genetic risk factor for LOAD that has been consistently replicated is the apolipoprotein E (APOE) locus 29 determined by the combined genotypes at the loci rs429358 and rs7412. In the past few years, GWASs have identified several additional genetic loci associated with LOAD.…”
Section: Alzheimer's Disease Gwa Datamentioning
confidence: 99%