A high-fat diet rich in corn oil reduces spontaneous locomotor activity and induces insulin resistance in mice

Wong, Ching; Botta, Amy; Pither, Jason; Dai, Chunping; Gibson, William T.; Ghosh, Sanjoy

doi:10.1016/j.jnutbio.2014.11.004

Cited by 42 publications

(39 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increased TEE in the WM group was due to an increase in SPA only during the rodent inactive, rather than active cycle, whereas Ex increased SPA in both cycles. HFD has been shown to reduce SPA (40); the present data suggest that inducing an energy deficit by any means might lessen the SPA-reducing effect of HFD, and that Ex may be especially protective in this regard. Ex also increased fat oxidation, as indicated by lower RQ values in both cycles whereas WM did not affect fat oxidation; similar exercise-specific effects on RQ have been reported in humans (3).…”

Section: Discussionmentioning

confidence: 50%

Comparison of Diet versus Exercise on Metabolic Function and Gut Microbiota in Obese Rats

Welly

Liu

Zidon

et al. 2016

Medicine &Amp; Science in Sports &Amp; Exercise

View full text Add to dashboard Cite

Cardiometabolic impairments that begin early in life are particularly critical, as they often predict metabolic dysfunction into adulthood. Obesity, high-fat diet (HFD), and inactivity are all associated with adipose tissue (AT) inflammation and insulin resistance (IR), major predictors of metabolic dysfunction. Recent evidence also has associated the gut microbiome with cardiometabolic health. PURPOSE Compare equal energy deficits induced by exercise and caloric reduction on cardiometabolic disease risk parameters including AT inflammation, IR and gut microbiota changes during HFD consumption. METHODS Obesity-prone rats fed HFD were exercise trained (Ex, n=10) or weight-matched to Ex via caloric reduction while kept sedentary (WM, n=10), and compared to ad libitum HFD-fed (Sed, n=10) rats for IR, systemic energetics and spontaneous physical activity (SPA), adiposity, and fasting metabolic parameters. Visceral, subcutaneous, periaortic, and brown AT, liver, aorta, and cecal digesta were examined. RESULTS Despite identical reductions in adiposity, Ex, but not WM, improved IR, increased SPA by ~26% (p<0.05 compared to WM and Sed), and reduced LDL cholesterol (p<0.05 compared to Sed). WM and Ex both reduced inflammatory markers in all AT depots and aorta, while only Ex increased indicators of mitochondrial function in brown AT. Ex significantly increased the relative abundance of cecal Streptococcaceae and decreased S24-7 and one undefined genus in Rikenellacea; WM induced similar changes that did not reach statistical significance. CONCLUSIONS Both Ex and WM reduced AT inflammation across depots, while Ex caused more robust changes to gut microbial communities, improved IR, increased fat oxidation, increased SPA, and increased indices of brown AT mitochondrial function. Our findings add to the growing body of literature indicating that there are weight-loss independent metabolic benefits of exercise.

show abstract

Section: Discussionmentioning

confidence: 50%

Comparison of Diet versus Exercise on Metabolic Function and Gut Microbiota in Obese Rats

Welly

Liu

Zidon

et al. 2016

Medicine &Amp; Science in Sports &Amp; Exercise

View full text Add to dashboard Cite

show abstract

“…Furthermore, the decrease in leptin secretion in the presence of LA and insulin may result in a decrease in satiety as this is regulated by leptin through the hypothalamus [77], leading to excessive energy consumption. In obesity prone C57BL/6 female mice a high LA corn oil diet was associated with reductions in respiratory exchange ratio, spontaneous locomotor activity, whole body glucose uptake and the expression of all of the PPAR subspecies in skeletal muscle (therefore reducing its ability to oxidise FA) in comparison to high oleic acid (OA) (from olive oil) fed animals [78].…”

Section: Linoleic Acid's Obesogenic Propertiesmentioning

confidence: 99%

Linoleic acid and the pathogenesis of obesity

Naughton

Mathai

Hryciw

et al. 2016

Prostaglandins & Other Lipid Mediators

120

View full text Add to dashboard Cite

“…However, nutrients and the caloric content of the diet can also affect SPA and, consequently, energy expenditure 24,25 . As diet modification, both in terms of calorie density and also macronutrients, is a common tool to promote body weight loss, a more comprehensive view of how dietchanging can affect total daily energy expenditure is of great importance.…”

Section: Nutrients Energy Intake and Spontaneous Physical Activitymentioning

confidence: 99%

“…Interestingly, high-fat diet has also been shown to decrease spontaneous physical activity in rodents 18,24 . This effect could be seen as early as after a few hours on the diet, and it remained throughout the 21 days in which mice received the diet rich in fat 18 .…”

Section: High-fat Dietmentioning

confidence: 99%

Translational Science: How experimental research has contributed to the understanding of spontaneous Physical Activity and Energy Homeostasis

Benfato

Moretto

Barthichoto

et al. 2017

Motriz: rev. educ. fis.

View full text Add to dashboard Cite

-Spontaneous physical activity (SPA) consists of all daily living activities other than volitional exercise (e.g. sports and fitness-related activities). SPA is an important component of energy expenditure and may protect from overweight and obesity. Little is known about the biological regulation of SPA, but animal research has contributed significantly to expand our knowledge in this field. Studies in rodents have shown that SPA is influenced by nutrients and volitional exercise. High-fat diet seems to decrease SPA, which contributes to weigh gain. Volitional exercise may also reduce SPA, helping to explain the commonly reported low efficiency of exercise to cause weight loss, and highlighting the need to find a volume/intensity of exercise to maximize total daily energy expenditure. Animal studies have also allowed for the identification of some brain areas and chemical mediators involved in SPA regulation. These discoveries could enable the development of new therapeutics aiming to enhance SPA.

show abstract

A high-fat diet rich in corn oil reduces spontaneous locomotor activity and induces insulin resistance in mice

Cited by 42 publications

References 49 publications

Comparison of Diet versus Exercise on Metabolic Function and Gut Microbiota in Obese Rats

Comparison of Diet versus Exercise on Metabolic Function and Gut Microbiota in Obese Rats

Linoleic acid and the pathogenesis of obesity

Translational Science: How experimental research has contributed to the understanding of spontaneous Physical Activity and Energy Homeostasis

Contact Info

Product

Resources

About